Genotoxicity of a novel thymol bearing oxipropanolamine derivative in human peripheral lymphocytes

Biologia ◽  
2022 ◽  
Author(s):  
Guncha Meredova ◽  
Esra Yıldız ◽  
Selen Şen ◽  
Mustafa Zengin ◽  
Hüseyin Aksoy
Keyword(s):  
Peripheral Lymphocytes ◽  
Human Peripheral Lymphocytes

Protection of resveratrol and its analogues against ethanol-induced oxidative DNA damage in human peripheral lymphocytes

2011 ◽  
Vol 721 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Yu Yan ◽  
Jingyu Yang ◽  
Guoliang Chen ◽  
Yanhua Mou ◽  
Yanan Zhao ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Peripheral Lymphocytes ◽  
Human Peripheral Lymphocytes

scholarly journals Clastogenic effects of food additive citric acid in human peripheral lymphocytes

2008 ◽  
Vol 56 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Serkan Yılmaz ◽  
Fatma Ünal ◽  
Deniz Yüzbaşıoğlu ◽  
Hüseyin Aksoy
Keyword(s):  
Citric Acid ◽  
Food Additive ◽  
Peripheral Lymphocytes ◽  
Human Peripheral Lymphocytes

Inhibition of mitogen-activated proliferation of human peripheral lymphocytes in vitro by propionic acid

1999 ◽  
Vol 96 (1) ◽  
pp. 99-103 ◽  
Author(s):  
Moacir WAJNER ◽  
Kátia D. SANTOS ◽  
Jeanine L. SCHLOTTFELDT ◽  
Maureen P. ROCHA ◽  
Clóvis M. D. WANNMACHER
Keyword(s):  
Propionic Acid ◽  
Concanavalin A ◽  
Methylmalonic Acid ◽  
Cellular Growth ◽  
Propionic Acidaemia ◽  
Pokeweed Mitogen ◽  
Recurrent Infections ◽  
Peripheral Lymphocytes ◽  
Human Peripheral Lymphocytes

Recurrent infections are common features in patients affected by propionic acidaemia (McKusick 232000) and methylmalonic acidaemia (McKusick 251000). Since these disorders are biochemically characterized by tissue accumulation of propionic acid and methylmalonic acid respectively, it is possible that these compounds may act as immunosuppressants. We therefore investigated the effect of propionate and methylmalonate on cellular growth of human peripheral lymphocytes stimulated in vitro by phytohaemagglutinin, concanavalin A and pokeweed mitogen, a recognized test of cellular immunocompetence. Lymphocytes were cultured in flat-bottomed 96-well microplates at 37 ;°C for 96 ;h (phytohaemagglutinin and concanavalin A) or 144 ;h (pokeweed mitogen) in the presence of one mitogen at different concentrations and of one acid added at doses of 1.0, 2.5 or 5.0 ;mM. Cell blastogenesis was measured by the incorporation of tritiated thymidine into cellular DNA and compared with that of identical cultures with no acid added (controls). A consistent and progressive inhibitory effect of propionic acid with increasing concentrations in culture was identified with all mitogens and was more pronounced with pokeweed mitogen. Lymphocyte blastogenesis was not altered in the presence of methylmalonic acid. The effect of propionate was observed only when the drug was added at the beginning (phytohaemagglutinin-activated) or until 24 ;h (concanavalin A- and pokeweed mitogen-activated) of culture. The viability of lymphocytes after treatment with the drug, as assessed by the Trypan Blue exclusion test, revealed no change when compared with the same untreated lymphocytes, indicating no lymphocytotoxic activity. In conclusion, propionic acid, which accumulates in tissues of patients with propionic acidaemia, causes ‘in vitro’ immunosuppression, which may be related to the recurrent infections characteristic of these patients.

The Maximum Low-Dose RBE of 17.4 and 40 keV Monochromatic X Rays for the Induction of Dicentric Chromosomes in Human Peripheral Lymphocytes

2003 ◽  
Vol 160 (5) ◽  
pp. 499-504 ◽  
Author(s):  
E. Schmid ◽  
M. Krumrey ◽  
G. Ulm ◽  
H. Roos ◽  
D. Regulla
Keyword(s):  
Low Dose ◽  
X Rays ◽  
Dicentric Chromosomes ◽  
Peripheral Lymphocytes ◽  
Human Peripheral Lymphocytes

Analysis of chromosome aberrations in human peripheral lymphocytes induced by in vitro α-particle irradiation

1996 ◽  
Vol 35 (3) ◽  
pp. 179-184 ◽  
Author(s):  
E. Schmid ◽  
L. Hieber ◽  
U. Heinzmann ◽  
H. Roos ◽  
A. M. Kellerer
Keyword(s):  
Chromosome Aberrations ◽  
Peripheral Lymphocytes ◽  
Particle Irradiation ◽  
Human Peripheral Lymphocytes

scholarly journals Effect of Glycosphingolipids Purified from Leishmania (Leishmania) amazonensis Amastigotes on Human Peripheral Lymphocytes

2003 ◽  
Vol 10 (3) ◽  
pp. 469-472 ◽  
Author(s):  
Selma Giorgio ◽  
Marcia Regina M. Santos ◽  
Anita H. Straus ◽  
Helio K. Takahashi ◽  
Clara Lúcia Barbiéri
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Human Lymphocyte ◽  
Leishmania Amazonensis ◽  
Peripheral Lymphocytes ◽  
Kinase C ◽  
Protein Kinase C Activity ◽  
Human Peripheral Lymphocytes

ABSTRACT The effect of purified glycosphingolipids from Leishmania (Leishmania) amazonensis on human lymphoproliferation, on expression of human lymphocyte and monocyte markers (CD3, CD4, CD8, CD14, CD19, and CD45), and on lymphocyte protein kinase C activity was analyzed.

Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms

2007 ◽  
Vol 615 (1-2) ◽  
pp. 134-142 ◽  
Author(s):  
Hitoshi Ishikawa ◽  
Takashi Ishikawa ◽  
Hidetaka Yamamoto ◽  
Akira Fukao ◽  
Kazuhito Yokoyama
Keyword(s):  
Gene Polymorphisms ◽  
Genotoxic Effects ◽  
Peripheral Lymphocytes ◽  
Human Peripheral Lymphocytes ◽  
Aldh2 Gene
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