Anisotropic properties of human cortical bone with osteogenesis imperfecta

2015 ◽  
Vol 15 (1) ◽  
pp. 155-167 ◽  
Author(s):  
Kalpana S. Katti ◽  
Chunju Gu ◽  
Dinesh R. Katti
Keyword(s):  
Osteogenesis Imperfecta ◽  
Cortical Bone ◽  
Anisotropic Properties ◽  
Human Cortical Bone

Microstructure, Spectroscopic Studies and Nanomechanical Properties of Human Cortical Bone with Osteogenesis Imperfecta

2014 ◽  
Vol 1621 ◽  
pp. 163-168
Author(s):  
Chunju Gu ◽  
Dinesh R. Katti ◽  
Kalpana S. Katti
Keyword(s):  
Fourier Transform ◽  
Osteogenesis Imperfecta ◽  
Cortical Bone ◽  
Type I Collagen ◽  
Experimental Studies ◽  
Spectroscopic Studies ◽  
Type I ◽  
Healthy Human ◽  
Electron Microscopies ◽  
Human Cortical Bone

ABSTRACTBone is a natural protein (collagen)-mineral (hydroxyapatite) nanocomposite with hierarchically organized structure. Our previous work has demonstrated orientational differences in stoichiometry of hydroxyapatite resulting from orientationally dependent collagen-mineral interactions in bone. The nature of these interactions has been investigated both through molecular dynamics simulations as well as nanomechanical and infrared spectroscopic experiments. In this study, we report experimental studies on human cortical bone with osteogenesis imperfecta (OI), a disease characterized by fragility of bones and other tissues rich in type I collagen. About 90% of OI cases result from causative variant in one of the two structural genes (COL1A1 or COL1A2) for type I procollagens. OI provides an interesting platform for investigating how alterations of collagen at the molecular level cause changes in structure and mechanics of bone. Fourier transform spectroscopy, electron microscopy (SEM), and nanomechanical experiments describe the structural and molecular differences in bone ultrastructure due to presence of diseases. Photoacoustic-Fourier transform infrared spectroscopy (PA-FTIR) experiments have been conducted to investigate the orientational differences in molecular structure of OI bone, which is also compared with that of healthy human cortical bone. Further, in situ SEM static nanomechanical testing is conducted in the transverse and longitudinal directions in the OI bone. Microstructural defects and abnormities of OI bone were ascertained using scanning electron microscopies. These results provide an insight into molecular basis of deformation and mechanical behavior of healthy human bone and OI bone.

Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates

Biomaterials ◽  
2014 ◽  
Vol 35 (21) ◽  
pp. 5472-5481 ◽  
Author(s):  
Elizabeth A. Zimmermann ◽  
Bernd Gludovatz ◽  
Eric Schaible ◽  
Björn Busse ◽  
Robert O. Ritchie
Keyword(s):  
Cortical Bone ◽  
Fracture Resistance ◽  
Strain Rates ◽  
Physiological Strain ◽  
Length Scales ◽  
Human Cortical Bone ◽  
Multiple Length Scales

scholarly journals Influence of loading condition and anatomical location on human cortical bone linear micro-cracks

2019 ◽  
Vol 85 ◽  
pp. 59-66 ◽  
Author(s):  
Rémy Gauthier ◽  
Max Langer ◽  
Hélène Follet ◽  
Cécile Olivier ◽  
Pierre-Jean Gouttenoire ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Loading Condition ◽  
Anatomical Location ◽  
Human Cortical Bone ◽  
Micro Cracks

In vivo quantification of age-related changes in human cortical bone thickness and porosity by HR-pQCT

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S22
Author(s):  
K.K. Nishiyama ◽  
H.M. Macdonald ◽  
H.R. Buie ◽  
D.A. Hanley ◽  
S.K. Boyd
Keyword(s):  
Cortical Bone ◽  
Bone Thickness ◽  
Cortical Bone Thickness ◽  
Human Cortical Bone ◽  
Age Related ◽  
Age Related Changes

Re-evaluating the toughness of human cortical bone

Bone ◽  
2006 ◽  
Vol 38 (6) ◽  
pp. 878-887 ◽  
Author(s):  
Q.D. Yang ◽  
B.N. Cox ◽  
R.K. Nalla ◽  
R.O. Ritchie
Keyword(s):  
Cortical Bone ◽  
Human Cortical Bone
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