Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates

Biomaterials ◽  
2014 ◽  
Vol 35 (21) ◽  
pp. 5472-5481 ◽  
Author(s):  
Elizabeth A. Zimmermann ◽  
Bernd Gludovatz ◽  
Eric Schaible ◽  
Björn Busse ◽  
Robert O. Ritchie
Keyword(s):  
Cortical Bone ◽  
Fracture Resistance ◽  
Strain Rates ◽  
Physiological Strain ◽  
Length Scales ◽  
Human Cortical Bone ◽  
Multiple Length Scales

scholarly journals Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales

2011 ◽  
Vol 108 (35) ◽  
pp. 14416-14421 ◽  
Author(s):  
E. A. Zimmermann ◽  
E. Schaible ◽  
H. Bale ◽  
H. D. Barth ◽  
S. Y. Tang ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Length Scales ◽  
Human Cortical Bone ◽  
Age Related ◽  
Multiple Length Scales ◽  
Age Related Changes

Fracture length scales in human cortical bone: The necessity of nonlinear fracture models

Biomaterials ◽  
2006 ◽  
Vol 27 (9) ◽  
pp. 2095-2113 ◽  
Author(s):  
Q.D. Yang ◽  
Brian N. Cox ◽  
Ravi K. Nalla ◽  
R.O. Ritchie
Keyword(s):  
Cortical Bone ◽  
Length Scales ◽  
Fracture Length ◽  
Human Cortical Bone ◽  
Nonlinear Fracture ◽  
Fracture Models

scholarly journals What is the influence of two strain rates on the relationship between human cortical bone toughness and micro-structure?

2019 ◽  
Vol 234 (3) ◽  
pp. 247-254 ◽  
Author(s):  
Rémy Gauthier ◽  
Hélène Follet ◽  
Max Langer ◽  
Françoise Peyrin ◽  
David Mitton
Keyword(s):  
Crack Propagation ◽  
Strain Rate ◽  
Cortical Bone ◽  
Static Loading ◽  
Fracture Mechanisms ◽  
Strain Rates ◽  
Micro Structure ◽  
Human Cortical Bone ◽  
Cross Links ◽  
Haversian System

Cortical bone fracture mechanisms are well studied under quasi-static loading. The influence of strain rate on crack propagation mechanisms needs to be better understood, however. We have previously shown that several aspects of the bone micro-structure are involved in crack propagation, such as the complete porosity network, including the Haversian system and the lacunar network, as well as biochemical aspects, such as the maturity of collagen cross-links. The aim of this study is to investigate the influence of strain rate on the toughness of human cortical bone with respect to its microstructure and organic non-collagenous composition. Two strain rates will be considered: quasi-static loading (10−4 s−1), a standard condition, and a higher loading rate (10−1 s−1), representative of a fall. Cortical bone samples were extracted from eight female donors (age 50–91 years). Three-point bending tests were performed until failure. Synchrotron radiation micro-computed tomography imaging was performed to assess bone microstructure including the Haversian system and the lacunar system. Collagen enzymatic cross-link maturation was measured using a high performance liquid chromatography column. Results showed that that under quasi-static loading, the elastic contribution of the fracture process is correlated to both the collagen cross-links maturation and the microstructure, while the plastic contribution is correlated only to the porosity network. Under fall-like loading, bone organization appears to be less linked to crack propagation.

Patterning of Soft Matter across Multiple Length Scales

2016 ◽  
Vol 26 (16) ◽  
pp. 2609-2616 ◽  
Author(s):  
Pim van der Asdonk ◽  
Hans C. Hendrikse ◽  
Marcos Fernandez-Castano Romera ◽  
Dion Voerman ◽  
Britta E. I. Ramakers ◽  
...  
Keyword(s):  
Soft Matter ◽  
Length Scales ◽  
Multiple Length Scales
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