Locally Advanced Rectal Cancer: Treatment Approach in Elderly Patients

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Francesca De Felice ◽  
Daniele Crocetti ◽  
Veronica Maiuri ◽  
Martina Parisi ◽  
Francesco Marampon ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Elderly Patients ◽  
Cancer Treatment ◽  
Treatment Approach ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Rectal Cancer Treatment

scholarly journals Cost drivers of locally advanced rectal cancer treatment—An analysis of a leading healthcare insurer

2021 ◽  
Vol 123 (4) ◽  
pp. 1023-1029
Author(s):  
Fabian Grass ◽  
Amit Merchea ◽  
Kellie L. Mathis ◽  
Nitin Mishra ◽  
Herbert Heien ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Treatment ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Cost Drivers ◽  
Rectal Cancer Treatment

The Role of Capecitabine in Locally Advanced Rectal Cancer Treatment

Drugs ◽  
2012 ◽  
Vol 72 (8) ◽  
pp. 1057-1073 ◽  
Author(s):  
Carlos Fernández-Martos ◽  
Miquel Nogué ◽  
Paloma Cejas ◽  
Víctor Moreno-García ◽  
Ana Hernández Machancoses ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Treatment ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Rectal Cancer Treatment

scholarly journals Treatment in locally advanced rectal cancer: a machine learning bibliometric analysis

2021 ◽  
Vol 14 ◽  
pp. 175628482110421
Author(s):  
Francesca De Felice ◽  
Daniele Crocetti ◽  
Niccolò Petrucciani ◽  
Liliana Belgioia ◽  
Paolo Sapienza ◽  
...  
Keyword(s):  
Machine Learning ◽  
Rectal Cancer ◽  
Cancer Treatment ◽  
Bibliometric Analysis ◽  
Locally Advanced ◽  
Neoadjuvant Treatment ◽  
Advanced Rectal Cancer ◽  
The United States ◽  
Locally Advanced Rectal Cancer ◽  
Rectal Cancer Treatment

A bibliometric analysis was performed using a machine learning bibliometric methodology in order to evaluate the research trends in locally advanced rectal cancer treatment between 2000 and 2020. Information regarding publication outputs, countries, institutions, journals, keywords, funding, and citation counts was retrieved from Scopus database. During the search process, a total of 2370 publications were identified. The vast majority of papers originated from the United States of America, reflecting also its research drive in the collaboration network. Neoadjuvant treatment was the topic most studied in the highly cited studies. New keywords, including neoadjuvant chemotherapy, multiparametric magnetic resonance imaging, circulating tumor DNA, and genetic heterogeneity, appeared in the last 2 years. The quantity of publications on locally advanced rectal cancer treatment since 2000 showed an evolving research field. The ‘new’ keywords explain where research is presently heading.

Impact of adjuvant treatment in elderly patients with locally advanced rectal cancer: A population-based retrospective study.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 3613-3613
Author(s):  
Shiru Lucy Liu ◽  
Pierre O'Brien ◽  
Yizhou Zhao ◽  
Wilma M Hopman ◽  
Nathan William Dana Lamond ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Elderly Patients ◽  
Cox Regression ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
The Elderly ◽  
Population Based ◽  
Locally Advanced Rectal Cancer ◽  
Curative Intent ◽  
Kaplan Meier

3613 Background: Little is known about the benefit and use of adjuvant chemotherapy (ADJ) in the elderly population (age ≥ 65) with locally advanced rectal cancer (LARC). We undertook a provincial review of LARC patients to evaluate the potential benefits, including survival and time to relapse (TTR), of ADJ in elderly patients. Methods: We performed a retrospective analysis of 286 LARC patients (stage 2 and 3) diagnosed between January 2010 and December 2013 from Nova Scotia, Canada, who underwent curative-intent surgery. Baseline patient, tumor and treatment characteristics were collected. Survival and TTR analysis were performed using Kaplan-Meier and Cox-regression statistics. Results: 152 patients were age ≥65, and 92 age ≥70. Median follow-up was 46 months. 178 patients (62%) received neoadjuvant chemo-radiation (NEOADJ). While 109 patients (81%) age < 65 received ADJ, only 68 patients (45%) age ≥ 65 received ADJ. Kaplan-Meier analysis revealed a significant survival and TTR advantage for ADJ irrespective of age (table). In cox-regression multivariate analysis, ECOG status, T stage, and ADJ were significant predictors of survival (p < 0.04), while age was not. Similarly, N stage, NEOADJ, and ADJ were significant predictors of TTR (p < 0.007). Poor ECOG status was the most common cause of ADJ omission. There was a significantly higher amount of grade≥ 1 chemotherapy-related toxicity experienced by patients age ≥ 65 treated with ADJ compared to no ADJ (77% vs 32%, p < 0.0001), which consisted mostly of diarrhea and mucositis. Toxicity was the main reason for non-completion of ADJ in the elderly. Conclusions: Elderly patients with LARC have significantly improved overall survival with ADJ, but the use of ADJ is lower than in patients age < 65. However, elderly patients experience more chemotherapy-related toxicities, leading to higher rates of early treatment discontinuation. [Table: see text]

Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer

Surgery Today ◽  
2019 ◽  
Vol 49 (8) ◽  
pp. 694-703 ◽  
Author(s):  
Tetsuro Tominaga ◽  
Toshiya Nagasaki ◽  
Takashi Akiyoshi ◽  
Yosuke Fukunaga ◽  
Yoshiya Fujimoto ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Elderly Patients ◽  
Neoadjuvant Therapy ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer
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