Biologic Therapies for Allergic Rhinitis and Nasal Polyposis

2021 ◽  
Vol 21 (6) ◽  
Author(s):  
Bob Geng ◽  
Michelle Dilley ◽  
Christine Anterasian
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Polyposis ◽  
Biologic Therapies

Immunology of Nasal Polyposis and Allergic Rhinitis

2016 ◽  
pp. 306-312
Author(s):  
Whitney W. Stevens ◽  
Kathryn E. Hulse
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Polyposis

scholarly journals Biologics for the Treatment of Allergic Rhinitis, Chronic Rhinosinusitis, and Nasal Polyposis

2020 ◽  
Vol 40 (4) ◽  
pp. 539-547
Author(s):  
William Eschenbacher ◽  
Matthew Straesser ◽  
Alice Knoeddler ◽  
Rung-chi Li ◽  
Larry Borish
Keyword(s):  
Allergic Rhinitis ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyposis

Stem cell factor in nasal polyposis and allergic rhinitis: Increased expression by structural cells is suppressed by in vivo topical corticosteroids

1997 ◽  
Vol 100 (3) ◽  
pp. 389-399 ◽  
Author(s):  
Young-Ki Kim ◽  
Noriaki Nakagawa ◽  
Koichi Nakano ◽  
Irakly Sulakvelidze ◽  
Jerry Dolovich ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Stem Cell ◽  
Stem Cell Factor ◽  
Nasal Polyposis ◽  
Topical Corticosteroids

R460 – Relation Between SPA and Symptoms of Patients With AR and NP

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P199-P199
Author(s):  
Deng Yuqin ◽  
Zezhang Tao ◽  
Yonggang Kong
Keyword(s):  
Allergic Rhinitis ◽  
Indirect Immunofluorescence ◽  
Nasal Polyposis ◽  
Protein A ◽  
Upper Airway ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Enzyme Linked Immunosorbent Assay ◽  
Immunofluorescence Method ◽  
Defensive Role

Problem The aim of this study was to examine if allergic rhinitis and nasal polyposis are associated with the level of surfactant protein-A. Methods Sinus mucosal biopsies were performed in patients with allergic rhinitis (n= 15), nasal polyposis (n=21) and controls (n= 10). Immunolocalization of surfactant protein was performed with antibodies to SP-A using Streptavidin Peroxidase Conjugated Method and indirect immunofluorescence method. Blood serums were obtained from three subjects in each group for enzyme-linked immunosorbent assay (ELISA) analysis of surfactant protein-A. Results By ELISA, AR (n =15) and NP (n = 21) showed significantly decreased levels of SP-A when compared with controls (n= 10), although these two groups were not statistically significant. Immunohistochemical investigation showed intense SP-A staining in the nasal epithelium of each groups, but weak staining in patients with AR and NP. Conclusion We report for the first time the expression of SP-A in both diseased and normal nasal mucosa using the indirect immunofluorescence method. There was an inverse relation between surfactant protein-A levels and symptoms and signs of rhinitis in patients with AR and NP. Significance SP-A may play a defensive role in the chronic inflammatory diseases of upper airway. Understanding the exact role of SP-A in the upper airway diseases will help develop novel treatment approaches for sinonasal pathoses.

Current and emerging biologic therapies for allergic rhinitis and chronic rhinosinusitis

2020 ◽  
Vol 20 (6) ◽  
pp. 609-619 ◽  
Author(s):  
Amelia Licari ◽  
Riccardo Castagnoli ◽  
Maria De Filippo ◽  
Thomas Foiadelli ◽  
Maria Angela Tosca ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Chronic Rhinosinusitis ◽  
Biologic Therapies

Allergic Rhinitis and Aspirin-Exacerbated Respiratory Disease as Predictors of the Olfactory Outcome after Endoscopic Sinus Surgery

2009 ◽  
Vol 23 (3) ◽  
pp. 348-353 ◽  
Author(s):  
Michael Katotomichelakis ◽  
Maria Riga ◽  
Spyridon Davris ◽  
Gregorios Tripsianis ◽  
Maria Simopoulou ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Respiratory Disease ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyposis ◽  
Sinus Surgery ◽  
Olfactory Acuity ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Negative Effect ◽  
Time Frames

Background Unlike the functional outcomes of endoscopic sinus surgery, which have been thoroughly studied, the effect of the surgery on olfactory performance and the relative predictive factors have not been adequately assessed by literature. Allergic rhinitis and aspirin-exacerbated respiratory disease (AERD) are examined as potential confounding factors of the olfactory outcome in patients with extensive nasal polyposis and rhinosinusitis treated with functional endoscopic sinus surgery (FESS). Methods A population of 116 adults with severe nasal polyposis was subjected to FESS after failure of the appropriate medical treatment. The olfactory outcome was quantified by Sniffin’ Sticks at the 1st, 3rd, and 6th postoperative month in relation to the concomitant presence of allergic rhinitis (n = 62) or AERD (n = 18). Results Allergic patients seemed to perform worse than nonallergic patients at all time frames. However, when patients with similar olfactory acuity, age, and medical history are compared, allergic rhinitis does not seem to affect the postoperative improvement of the composite threshold-discrimination-identification scores. The same seems to apply for the likelihood of acquiring normosmia after surgery. On the contrary, AERD significantly limits the recovery of olfactory function at all follow-up examinations and patients with AERD are unlikely to become normosmic. Conclusion The olfactory recovery after FESS for nasal polyposis is significantly affected by the concomitant presence of AERD. Although allergy seems to have a general negative effect on olfactory acuity, it was not found to affect the extent of the olfactory improvement, when patients with comparable preoperative characteristics are addressed.

Eosinophils in the Field of Nasal Polyposis: Towards a Better Understanding of Biologic Therapies

2021 ◽  
Author(s):  
Thibault Vanderhaegen ◽  
Isabelle Gengler ◽  
Arnaud Dendooven ◽  
Cecile Chenivesse ◽  
Guillaume Lefèvre ◽  
...  
Keyword(s):  
Nasal Polyposis ◽  
Biologic Therapies
Sign in / Sign up

Export Citation Format

Share Document