scholarly journals Therapeutic Strategies for Modulating the Extracellular Matrix to Improve Pancreatic Islet Function and Survival After Transplantation

2018 ◽  
Vol 18 (7) ◽  
Author(s):  
Alexandra M. Smink ◽  
Paul de Vos
Keyword(s):  
Extracellular Matrix ◽  
Pancreatic Islet ◽  
Therapeutic Strategies ◽  
Islet Function

scholarly journals Culture on a native bone marrow‐derived extracellular matrix restores the pancreatic islet basement membrane, preserves islet function, and attenuates islet immunogenicity

2020 ◽  
Vol 34 (6) ◽  
pp. 8044-8056
Author(s):  
Hanzhou Wang ◽  
Shengxian Li ◽  
Qiuxia Dai ◽  
Aaron Gonzalez ◽  
Olivia N. Tran ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Extracellular Matrix ◽  
Basement Membrane ◽  
Pancreatic Islet ◽  
Islet Function ◽  
Native Bone

Correlations between Serum 25-Hydroxyvitamin D and Pancreatic Islet Function in Type 2 Diabetics

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 779-P
Author(s):  
NAN LI ◽  
MING CHEN ◽  
JIAQI DONG ◽  
SHAOLING YANG ◽  
LU XU ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Islet Function ◽  
Hydroxyvitamin D ◽  
Type 2 Diabetics ◽  
25 Hydroxyvitamin D

Synchronized Microfluidic System to Dynamically Assess Pancreatic Islet Function beyond Glucose-Stimulated Insulin Secretion

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2162-P
Author(s):  
STEPHAN NIEUWOUDT ◽  
RUTH MCDOWELL ◽  
HUI ZHANG ◽  
JOHN P. KIRWAN
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Islet ◽  
Microfluidic System ◽  
Islet Function ◽  
Glucose Stimulated Insulin Secretion

Eicosanoids as pluripotential modulators of pancreatic islet function

Diabetes ◽  
1988 ◽  
Vol 37 (4) ◽  
pp. 367-370 ◽  
Author(s):  
R. P. Robertson
Keyword(s):  
Pancreatic Islet ◽  
Islet Function

Pancreatic islet function in nondiabetic and diabetic BB rats

Diabetes ◽  
1993 ◽  
Vol 42 (9) ◽  
pp. 1310-1317 ◽  
Author(s):  
M. Teruya ◽  
S. Takei ◽  
L. E. Forrest ◽  
A. Grunewald ◽  
E. K. Chan ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Islet Function ◽  
Bb Rats

The stimulus-secretion coupling of glucose-induced insulin release: Effects of valinomycin upon pancreatic islet function

1979 ◽  
Vol 196 (1) ◽  
pp. 54-63 ◽  
Author(s):  
A.Carlos Boschero ◽  
Shoji Kawazu ◽  
Abdullah Sener ◽  
André Herchuelz ◽  
Willy J. Malaisse
Keyword(s):  
Insulin Release ◽  
Pancreatic Islet ◽  
Islet Function ◽  
Stimulus Secretion Coupling

Lysosomes and pancreatic islet function

1988 ◽  
Vol 252 (1) ◽  
Author(s):  
AnnikaH. Schnell ◽  
I. Swenne ◽  
L.A.H. Borg
Keyword(s):  
Pancreatic Islet ◽  
Islet Function

scholarly journals Prenatal androgen exposure programs metabolic dysfunction in female mice

2010 ◽  
Vol 207 (2) ◽  
pp. 213-223 ◽  
Author(s):  
Alison V Roland ◽  
Craig S Nunemaker ◽  
Susanna R Keller ◽  
Suzanne M Moenter
Keyword(s):  
Pancreatic Islet ◽  
Polycystic Ovary ◽  
Islet Function ◽  
Metabolic Dysfunction ◽  
Isolated Pancreatic Islets ◽  
Female Mice ◽  
Metabolic Characteristics ◽  
Reproductive Axis ◽  
Androgen Exposure

Polycystic ovary syndrome (PCOS) is a common fertility disorder with metabolic sequelae. Our laboratory previously characterized reproductive phenotypes in a prenatally androgenized (PNA) mouse model for PCOS. PNA mice exhibited elevated testosterone and LH levels, irregular estrous cycles, and neuroendocrine abnormalities suggesting increased central drive to the reproductive system. In this study, we examined metabolic characteristics of female PNA mice. PNA mice exhibited increased fasting glucose and impaired glucose tolerance (IGT) that were independent of age and were not associated with changes in body composition or peripheral insulin sensitivity. IGT was associated with defects in pancreatic islet function leading to an impaired response to high glucose, consistent with impaired insulin secretion. Exposure of isolated pancreatic islets to androgen in vitro demonstrated an impaired response to glucose stimulation similar to that in PNA mice, suggesting androgens may have activational in addition to organizational effects on pancreatic islet function. PNA mice also exhibited increased size of visceral adipocytes, suggesting androgen-programed differences in adipocyte differentiation and/or function. These studies demonstrate that in addition to causing reproductive axis abnormalities, in utero androgen exposure can induce long-term metabolic alterations in female mice.

Pancreatic Islet Function in ω3 Fatty Acid-Depleted Rats: Glucose Metabolism and Nutrient-Stimulated Insulin Release

Endocrine ◽  
2006 ◽  
Vol 29 (3) ◽  
pp. 457-466 ◽  
Author(s):  
Berrin Oguzhan ◽  
Ying Zhang ◽  
Karim Louchami ◽  
Philippe Courtois ◽  
Laurence Portois ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Glucose Metabolism ◽  
Insulin Release ◽  
Pancreatic Islet ◽  
Islet Function
Sign in / Sign up

Export Citation Format

Share Document