Effects of Antihypertensive Treatment on Endothelial Function

2011 ◽  
Vol 13 (4) ◽  
pp. 276-281 ◽  
Author(s):  
Agostino Virdis ◽  
Lorenzo Ghiadoni ◽  
Stefano Taddei
Keyword(s):  
Endothelial Function ◽  
Antihypertensive Treatment

scholarly journals Effects of antihypertensive treatment on endothelial function in postmenopausal hypertensive women. A significant role for aldosterone inhibition

2011 ◽  
Vol 12 (4) ◽  
pp. 446-455 ◽  
Author(s):  
Rosario Rossi ◽  
Annachiara Nuzzo ◽  
Daniele Iaccarino ◽  
Antonella Lattanzi ◽  
Giorgia Origliani ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Optimal Control ◽  
Endothelial Function ◽  
Postmenopausal Women ◽  
Antihypertensive Therapy ◽  
Antihypertensive Treatment ◽  
Pressure Control ◽  
Ultrasound Study ◽  
Optimal Blood Pressure

Introduction: Endothelial dysfunction is a well-demonstrated independent predictor of cardiovascular events in hypertensive postmenopausal women. Accordingly, it is plausible that improving endothelial function could represent an adjunctive target for antihypertensive treatment. The aim of our study was to evaluate the effect of pharmacologic treatment on endothelial function in the specific population of hypertensive postmenopausal women. Methods: A total of 320 consecutive hypertensive postmenopausal women underwent a high-resolution ultrasound study of the brachial artery at baseline and after six months, while ‘optimal’ control of blood pressure (maintenance of blood pressure values below 140/90 mmHg at all follow-up visits) was achieved using antihypertensive therapy. Endothelial function was measured as flow-mediated dilation, using ultrasound method. Results: After six months of treatment, flow-mediated dilatation (FMD) had significantly improved in the majority of patients (n = 257 [80.3% of the entire population]; FMD = 8.1 ± 1.0% at baseline vs. 10.6 ± 1.5% after follow-up; p < 0.001), but it had not changed or worsened in others (n = 63 [19.7%]; FMD = 8.2 ± 1.2% at baseline vs. 7.6 ± 1.0% after six months; p = ns). Improvement of endothelial function, at multivariate analysis, resulted independently associated with the use of aldosterone inhibitors (odds ratio = 2.15; 95% confidence interval: 1.55–2.75; p = 0.001). Conclusions: This study demonstrates that a significant improvement in endothelial function may be obtained after six months of an optimal antihypertensive therapy. Among all hypertensive postmenopausal women that achieved an optimal control of blood pressure during follow-up, the use of drugs that inhibit aldosterone receptors was associated with an improvement of endothelial function, beyond the ‘optimal’ blood pressure control.

scholarly journals The Effect of Antihypertensive Drugs on Endothelial Function as Assessed by Flow-Mediated Vasodilation in Hypertensive Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Michiaki Miyamoto ◽  
Kazuhiko Kotani ◽  
Shun Ishibashi ◽  
Nobuyuki Taniguchi
Keyword(s):  
Clinical Trial ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Antihypertensive Treatment ◽  
Antihypertensive Drugs ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Angiotensin Ii Receptor ◽  
Converting Enzyme Inhibitors ◽  
Hypertensive Patients ◽  
Flow Mediated Vasodilation

Endothelial dysfunction is found in hypertensive patients and may serve as a prognostic marker of future cardiovascular events. Endothelial function can be assessed noninvasively by flow-mediated vasodilation (FMD). The goal of this paper is to summarize comprehensively the clinical trials that investigated the effects of antihypertensive drugs on endothelial function assessed by FMD in hypertensive patients. A PubMed-based search found 38 clinical trial papers published from January 1999 to June 2011. Significant improvement of FMD after antihypertensive treatment was shown in 43 of 71 interventions (among 38 clinical trial papers). Angiotensin II receptor blockers and angiotensin converting enzyme inhibitors appeared to improve FMD more than other drug types. Antihypertensive treatment can improve endothelial dysfunction when assessed by FMD, although there are conflicting data that require further research.

Sign in / Sign up

Export Citation Format

Share Document