Kinetic and Thermodynamic Investigation of Human Serum Albumin Interaction with Anticancer Glycine Derivative of Platinum Complex by Using Spectroscopic Methods and Molecular Docking

2019 ◽  
Vol 190 (2) ◽  
pp. 506-528 ◽  
Author(s):  
Afrooz Shiekhzadeh ◽  
Nasrin Sohrabi ◽  
Mahboube Eslami Moghadam ◽  
Mohsen Oftadeh
Keyword(s):  
Molecular Docking ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Platinum Complex ◽  
Spectroscopic Methods ◽  
Thermodynamic Investigation ◽  
Glycine Derivative

Investigation of the interaction of batatasin derivatives with human serum albumin using voltammetric and spectroscopic methods

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36281-36292 ◽  
Author(s):  
Jinhua Zhu ◽  
Weiping Hu ◽  
Dandan Wu ◽  
Lanlan Chen ◽  
Xiuhua Liu
Keyword(s):  
Molecular Docking ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Spectroscopic Methods ◽  
Binding Properties ◽  
Helix Structure ◽  
Α Helix

The binding properties of batatasin derivatives with HSA were estimated by voltammetric, spectroscopic, and molecular docking methods. There were non-electroactive complexes formed between them. And the α-helix structure in HSA was reduced.

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