Effects of Zinc Acetate on Serum Zinc Concentrations in Chronic Liver Diseases: a Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial and a Dose Adjustment Trial

We sought to investigate the influence of serum zinc (Zn) concentration on sarcopenia in chronic liver diseases (CLDs, n = 372, median age = 65 years, 147 liver cirrhosis (LC) cases (39.5%)). Sarcopenia was defined by low grip strength and low skeletal muscle mass. Study subjects were divided into the following three groups (High-, Intermediate-, and Low-Zn groups) based on the baseline serum Zn level. The impacts of serum Zn concentration on sarcopenia were examined. The median (interquartile range) serum Zn concentration for all cases was 72.85 (63.7, 81.45) μg/dL. The proportions of sarcopenia in the High-Zn, Intermediate-Zn, and Low-Zn groups were 10.75% (10/93), 11.23% (21/187), and 27.17% (25/92), respectively (P = 0.9046 (High vs. Intermediate), P = 0.0007 (Intermediate vs. Low), P = 0.0044 (High vs. Low), overall P value = 0.0009). The median serum Zn concentrations in patients with sarcopenia, pre-sarcopenia, and control were 66.35, 73.1 and 73.8 μg/dL, respectively (P = 0.0234 (sarcopenia vs. pre-sarcopenia), P = 0.2116 (pre-sarcopenia vs. control), P = 0.0002 (sarcopenia vs. control), overall P value = 0.0016). In the multivariate analyses of factors linked to the presence of sarcopenia, Low-Zn was an independent predictor for all cases (P = 0.0236) and LC cases (P = 0.0082). In conclusion, Zn deficiency can be an independent predictor for sarcopenia in patients with CLDs.

Download Full-text

Efficacy of CE14 (human placenta preparation) in a double blind trial on chronic liver diseases

Kanzo ◽

10.2957/kanzo.15.162 ◽

1974 ◽

Vol 15 (3) ◽

pp. 162-171 ◽

Cited By ~ 2

Author(s):

Hideo UEDA ◽

Hidemasa OKUMURA ◽

Masaharu HORIGUCHI ◽

Toshihiko NAMIHISA ◽

Taikobo ONODA ◽

...

Keyword(s):

Human Placenta ◽

Liver Diseases ◽

Chronic Liver ◽

Double Blind Trial ◽

Chronic Liver Diseases ◽

Double Blind ◽

Blind Trial

Download Full-text

Examination of serum zinc levels in patients with chronic liver diseases

Kanzo ◽

10.2957/kanzo.60.99 ◽

2019 ◽

Vol 60 (3) ◽

pp. 99-101

Author(s):

Yohji Honda ◽

Keiichi Masaki

Keyword(s):

Liver Diseases ◽

Serum Zinc ◽

Chronic Liver ◽

Chronic Liver Diseases ◽

Zinc Levels ◽

Serum Zinc Levels

Download Full-text

Serum Zinc Level and non-Protein Respiratory Quotient in Patients with Chronic Liver Diseases

Journal of Clinical Medicine ◽

10.3390/jcm9010255 ◽

2020 ◽

Vol 9 (1) ◽

pp. 255

Author(s):

Hiroki Nishikawa ◽

Ryo Takata ◽

Hirayuki Enomoto ◽

Kazunori Yoh ◽

Yoshinori Iwata ◽

...

Keyword(s):

Correlation Coefficient ◽

Respiratory Quotient ◽

Liver Diseases ◽

Characteristic Curve ◽

Serum Zinc ◽

Zinc Level ◽

Chronic Liver ◽

Chronic Liver Diseases ◽

Median Serum ◽

Serum Zn

We sought to clarify the correlation between non-protein respiratory quotient (npRQ) in indirect calorimetry and serum zinc (Zn) level in chronic liver diseases (CLDs, n = 586, 309 liver cirrhosis (LC) patients, median age = 63 years). Clinical parameters potentially linked to npRQ <0.85 (best cutoff point for the prognosis in LC patients) were also examined in receiver operating characteristic curve (ROC) analyses. The median npRQ was 0.86. The median serum Zn level was 64 μg/dL. The median npRQ in patients with non-LC, Child–Pugh A, Child–Pugh B and Child–Pugh C were 0.89, 0.85, 0.83 and 0.82 (overall p < 0.0001)). The median serum Zn level in patients with npRQ <0.85 (58 μg/dL) was significantly lower than that in patients with npRQ ≥ 0.85 (68 μg/dL) (p < 0.0001). The correlation coefficient (r) between npRQ level and serum Zn level for all cases was 0.40 (p < 0.0001). Similar tendencies were observed in all subgroup analyses. The highest correlation coefficient between serum Zn level and npRQ was found in patients with Child–Pugh C (n = 22, r = 0.69). In ROC analyses for npRQ <0.85, serum Zn level had the highest area under the ROC (AUC) among baseline laboratory parameters (AUC = 0.69). In conclusion, serum Zn level can be helpful for npRQ in patients with CLDs.

Download Full-text

Serum Zinc Level Is Associated with Frailty in Chronic Liver Diseases

Journal of Clinical Medicine ◽

10.3390/jcm9051570 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1570 ◽

Cited By ~ 1

Author(s):

Hiroki Nishikawa ◽

Kazunori Yoh ◽

Hirayuki Enomoto ◽

Yoshinori Iwata ◽

Yoshiyuki Sakai ◽

...

Keyword(s):

Liver Diseases ◽

Serum Zinc ◽

Body Weight Loss ◽

Zinc Level ◽

Clinical Syndrome ◽

Chronic Liver ◽

Chronic Liver Diseases ◽

Serum Zn ◽

Total Body ◽

Frailty Score

We sought to examine the serum zinc (Zn) level and frailty in patients with chronic liver diseases (CLDs, n = 285, 107 liver cirrhosis cases, median age = 66 years). Frailty was defined as a clinical syndrome in which three or more of the following criteria were met (frailty score 3, 4, or 5): unintentional body weight loss, self-reported exhaustion, muscle weakness (grip strength: <26 kg in men and <18 kg in women), slow walking speed (<1.0 m/s), and low physical activity. Robust (frailty score 0), prefrail (frailty score 1 or 2), and frailty were found in 90 (31.6%), 157 (55.1%), and 38 (13.3%), respectively. The median serum Zn levels in patients with frailty, prefrailty, and robust were 59.7 μg/dL, 72.8 μg/dL, and 76.9 μg/dL, respectively (p-values: frailty vs. prefrail, p < 0.0001; prefrail vs. robust, p = 0.0063; frailty vs. robust, p < 0.0001; overall p < 0.0001). For all cases, variables with absolute values of correlation coefficient with frailty score (0–5) ≥ 0.3 were age (rs = 0.3570, p < 0.0001), serum albumin (rs = −0.3212, p < 0.0001), extracellular water to total body water ratio using bioimpedance analysis (rs = 0.4386, p < 0.0001), and serum Zn level (rs = −0.3406, p < 0.0001). In conclusion, decreased serum Zn level in patients with CLDs can be closely associated with the presence of frailty.

Download Full-text

Controlled trial of D-penicillamine with low dosis in the treatment of chronic liver diseases

Gastroenterologia Japonica ◽

10.1007/bf02774310 ◽

1980 ◽

Vol 15 (4) ◽

pp. 374-378 ◽

Cited By ~ 1

Author(s):

Hiroshi Nakano ◽

Saburo Ohnishi ◽

Tomoyoshi Sugiyama ◽

Masami Miyamura ◽

Hiroo Imura ◽

...

Keyword(s):

Liver Diseases ◽

Controlled Trial ◽

Chronic Liver ◽

Chronic Liver Diseases

Download Full-text

Multi-Micronutrient Fortified Rice Improved Serum Zinc and Folate Concentrations of Cambodian School Children. A Double-Blinded Cluster-Randomized Controlled Trial

Nutrients ◽

10.3390/nu11122843 ◽

2019 ◽

Vol 11 (12) ◽

pp. 2843

Author(s):

Khov Kuong ◽

Pety Tor ◽

Marlene Perignon ◽

Marion Fiorentino ◽

Chhoun Chamnan ◽

...

Keyword(s):

Controlled Trial ◽

Serum Zinc ◽

Vulnerable Groups ◽

Serum Folate ◽

Micronutrient Deficiencies ◽

Double Blind ◽

Micronutrient Status ◽

Zinc Concentrations ◽

Cluster Randomized ◽

The Impact

Background: Within Cambodia, micronutrient deficiencies continue to be prevalent in vulnerable groups, such as women and children. Fortification of staple foods such as rice could be a promising strategy for Cambodia to improve micronutrient status. Objective: Our objective was to investigate the impact of multiple-micronutrient fortified rice (MMFR), distributed through a World Food Program school-meals program (WFP-SMP) on serum zinc concentrations and folate status in a double-blind, cluster-randomized, placebo-controlled trial. Methods: Sixteen schools were randomly assigned to receive one of three different types of extruded-fortified rice (UltraRice Original (URO), UltraRice New (URN), or NutriRice) or unfortified rice (placebo) six days a week for six months. A total of 1950 schoolchildren (6–16 years old) participated in the study. Serum zinc (all groups) and folate (only in NutriRice and placebo group) concentrations were assessed from morning non-fasting antecubital blood samples and were measured at three time points (baseline and after three and six months). Results: After six months of intervention, serum zinc concentrations were significantly increased in all fortified rice group compared to placebo and baseline (0.98, 0.85 and 1.40 µmol/L for URO, URN and NutriRice, respectively) (interaction effect: p < 0.001 for all). Children in the intervention groups had a risk of zinc deficiencies of around one third (0.35, 039, and 0.28 for URO, URN, and NutriRice, respectively) compared to the placebo (p < 0.001 for all). The children receiving NutriRice had higher serum folate concentrations at endline compared to children receiving normal rice (+2.25 ng/mL, p = 0.007). Conclusions: This study showed that the high prevalence of zinc and folate deficiency in Cambodia can be improved through the provision of MMFR. As rice is the staple diet for Cambodia, MMFR should be considered to be included in the school meal program and possibilities should be explored to introduce MMFR to the general population.

Download Full-text