Delta-Aminolevulinic Acid Dehydratase, Low Blood Lead Levels, Social Factors, and Intellectual Function in an Afro-Brazilian Children Community

2021 ◽  
Author(s):  
Homegnon A. F. Bah ◽  
Ana Laura S. dos Anjos ◽  
Erival A. Gomes-Júnior ◽  
Matheus J. Bandeira ◽  
Chrissie F. de Carvalho ◽  
...  
Keyword(s):  
Social Factors ◽  
Aminolevulinic Acid ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Intellectual Function ◽  
Acid Dehydratase ◽  
Lead Levels ◽  
Brazilian Children ◽  
Afro Brazilian

scholarly journals Association between Blood Lead Levels and Delta-Aminolevulinic Acid Dehydratase in Pregnant Women

2017 ◽  
Vol 14 (4) ◽  
pp. 432 ◽  
Author(s):  
Osmel La-Llave-León ◽  
Edna Méndez-Hernández ◽  
Francisco Castellanos-Juárez ◽  
Eloísa Esquivel-Rodríguez ◽  
Fernando Vázquez-Alaniz ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Aminolevulinic Acid ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Acid Dehydratase ◽  
Lead Levels

Delta-Aminolevulinic Acid Dehydratase Enzyme Activity and Susceptibility to Lead Toxicity in Uganda’s Urban Children

2021 ◽  
Author(s):  
Ambrose Mukisa ◽  
Denis M Kasozi ◽  
Claire Aguttu ◽  
Joseph Kyambadde
Keyword(s):  
Enzyme Activity ◽  
Aminolevulinic Acid ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Urban Children ◽  
Sub Saharan Africa ◽  
Nutrition Status ◽  
Blood Lead Levels ◽  
Acid Dehydratase ◽  
Lead Levels

Rapid industrialization, urbanization, and population explosion in sub-Saharan Africa escalate environmental Lead levels with subsequent elevation of blood Lead levels in children. Nutrition status, age, and genetics govern one’s susceptibility to Lead toxicity. This study expounded this susceptibility by relating blood Lead levels, d-aminolevulinic acid dehydratase enzyme activity (ALAD), and genetic variations of proteins that code for ALAD enzyme in urban children of Uganda. Spectrophotometric analysis for blood Lead (BL), hemoglobin levels, and determination d-levels aminolevulinic acid dehydratase enzyme activity of the blood samples from 198 children were performed prior to a polymerase chain reaction and restriction fragment length digestion for ALAD polymorphism was done. Up to 99.5% of samples coded for the ALAD1 allele whereas 0.05% coded for ALAD2. Genotypes ALAD2-2 members had elevated BLL (mean 14.1 µg/dL) and reduced ALAD enzyme activity compared to others. This, therefore, implies that the majority of children hoard BL which may affect them later in life.

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