Human adipose-Derived Mesenchymal Stem Cells Improve Motor Functions and are Neuroprotective in the 6-Hydroxydopamine-Rat Model for Parkinson’s Disease when Cultured in Monolayer Cultures but Suppress Hippocampal Neurogenesis and Hippocampal Memory Function when Cultured in Spheroids

2014 ◽  
Vol 11 (1) ◽  
pp. 133-149 ◽  
Author(s):  
Jürgen Berg ◽  
Manfred Roch ◽  
Jennifer Altschüler ◽  
Christine Winter ◽  
Anne Schwerk ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Memory Function ◽  
Hippocampal Neurogenesis ◽  
Motor Functions ◽  
Monolayer Cultures ◽  
6 Hydroxydopamine

Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's disease

2008 ◽  
Vol 52 (7) ◽  
pp. 1332-1342 ◽  
Author(s):  
Gaëlle Bouchez ◽  
Luc Sensebé ◽  
Patrick Vourc’h ◽  
Lucette Garreau ◽  
Sylvie Bodard ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Partial Recovery ◽  
Dopaminergic Pathway ◽  
Adult Mesenchymal Stem Cells

Neuroprotective effect of bone marrow derived mesenchymal stem cell secretome in 6-OHDA-induced Parkinson's disease

2021 ◽  
Author(s):  
Dhruv Mahendru ◽  
Ashish Jain ◽  
Seema Bansal ◽  
Deepti Malik ◽  
Neha Dhir ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Bone Marrow ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Neuroprotective Effect ◽  
Behavioral Parameters ◽  
Old Rats ◽  
6 Hydroxydopamine

Aim: The aim of the study was to evaluate the neuroprotective effect of bone marrow stem cell secretome in the 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. Materials & methods: Secretome prepared from mesenchymal stem cells of 3-month-old rats was injected daily for 7 days between days 7 and 14 after 6-OHDA administration. After 14 days, various neurobehavioral parameters were conducted. These behavioral parameters were further correlated with biochemical and molecular findings. Results & conclusion: Impaired neurobehavioral parameters and increased inflammatory, oxidative stress and apoptotic markers in the 6-OHDA group were significantly modulated by secretome-treated rats. In conclusion, mesenchymal stem cells-derived secretome could be further explored for the management of Parkinson's disease.

Therapeutic potentials of human microfluidic encapsulated conjunctival mesenchymal stem cells on the rat model of Parkinson's disease

2021 ◽  
Vol 123 ◽  
pp. 104703
Author(s):  
Meysam Forouzandeh ◽  
Mohammad Reza Bigdeli ◽  
Hossein Mostafavi ◽  
Samad Nadri ◽  
Mehdi Eskandari
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Rat Model

Testing alternatives: the use of adipose-derived mesenchymal stem cells to slow neurodegeneration in a rat model of Parkinson’s disease

2019 ◽  
Vol 46 (6) ◽  
pp. 5841-5858 ◽  
Author(s):  
Fatma Y. Meligy ◽  
Dalia A. Elgamal ◽  
Eman S. H. Abd Allah ◽  
Naglaa K. Idriss ◽  
Nagwa M. Ghandour ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Rat Model

Physical exercise and human adipose‐derived mesenchymal stem cells ameliorate motor disturbances in a male rat model of Parkinson's disease

2019 ◽  
Vol 97 (9) ◽  
pp. 1095-1109 ◽  
Author(s):  
Jaison D. Cucarián ◽  
Jenny P. Berrío ◽  
Cristiano Rodrigues ◽  
Mariana Zancan ◽  
Márcia R. Wink ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Physical Exercise ◽  
Rat Model ◽  
Male Rat ◽  
Motor Disturbances

Transplanted Wharton’s jelly mesenchymal stem cells improve memory and brain hippocampal electrophysiology in rat model of Parkinson’s disease

2020 ◽  
Vol 110 ◽  
pp. 101865
Author(s):  
Maryam Sadat Jalali ◽  
Alireza Sarkaki ◽  
Yaghoub Farbood ◽  
Seyed saeed Azandeh ◽  
Esrafil Mansouri ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Wharton’S Jelly ◽  
Wharton's Jelly
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