Transplanted Wharton’s jelly mesenchymal stem cells improve memory and brain hippocampal electrophysiology in rat model of Parkinson’s disease

2020 ◽  
Vol 110 ◽  
pp. 101865
Author(s):  
Maryam Sadat Jalali ◽  
Alireza Sarkaki ◽  
Yaghoub Farbood ◽  
Seyed saeed Azandeh ◽  
Esrafil Mansouri ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Wharton’S Jelly ◽  
Wharton's Jelly

Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's disease

2008 ◽  
Vol 52 (7) ◽  
pp. 1332-1342 ◽  
Author(s):  
Gaëlle Bouchez ◽  
Luc Sensebé ◽  
Patrick Vourc’h ◽  
Lucette Garreau ◽  
Sylvie Bodard ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Partial Recovery ◽  
Dopaminergic Pathway ◽  
Adult Mesenchymal Stem Cells

Therapeutic potentials of human microfluidic encapsulated conjunctival mesenchymal stem cells on the rat model of Parkinson's disease

2021 ◽  
Vol 123 ◽  
pp. 104703
Author(s):  
Meysam Forouzandeh ◽  
Mohammad Reza Bigdeli ◽  
Hossein Mostafavi ◽  
Samad Nadri ◽  
Mehdi Eskandari
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Rat Model

Testing alternatives: the use of adipose-derived mesenchymal stem cells to slow neurodegeneration in a rat model of Parkinson’s disease

2019 ◽  
Vol 46 (6) ◽  
pp. 5841-5858 ◽  
Author(s):  
Fatma Y. Meligy ◽  
Dalia A. Elgamal ◽  
Eman S. H. Abd Allah ◽  
Naglaa K. Idriss ◽  
Nagwa M. Ghandour ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Rat Model

scholarly journals Intrathecal Injection in a Rat Model: A Potential Route to Deliver Human Wharton’s Jelly-Derived Mesenchymal Stem Cells into the Brain

2020 ◽  
Vol 21 (4) ◽  
pp. 1272 ◽  
Author(s):  
Hyeongseop Kim ◽  
Duk L. Na ◽  
Na Kyung Lee ◽  
A Ran Kim ◽  
Seunghoon Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Intrathecal Injection ◽  
Wharton’S Jelly ◽  
Sprague Dawley ◽  
Wharton's Jelly ◽  
Sprague Dawley Rats ◽  
The Brain ◽  
Underlying Pathology

Mesenchymal stem cells (MSCs) are considered as promising therapeutic agents for neurodegenerative disorders because they can reduce underlying pathology and also repair damaged tissues. Regarding the delivery of MSCs into the brain, intravenous and intra-arterial routes may be less feasible than intraparenchymal and intracerebroventricular routes due to the blood–brain barrier. Compared to the intraparenchymal or intracerebroventricular routes, however, the intrathecal route may have advantages: this route can deliver MSCs throughout the entire neuraxis and it is less invasive since brain surgery is not required. The objective of this study was to investigate the distribution of human Wharton’s jelly-derived MSCs (WJ-MSCs) injected via the intrathecal route in a rat model. WJ-MSCs (1 × 106) were intrathecally injected via the L2-3 intervertebral space in 6-week-old Sprague Dawley rats. These rats were then sacrificed at varying time points: 0, 6, and 12 h following injection. At 12 h, a significant number of MSCs were detected in the brain but not in other organs. Furthermore, with a 10-fold higher dose of WJ-MSCs, there was a substantial increase in the number of cells migrating to the brain. These results suggest that the intrathecal route can be a promising route for the performance of stem cell therapy for CNS diseases.

Physical exercise and human adipose‐derived mesenchymal stem cells ameliorate motor disturbances in a male rat model of Parkinson's disease

2019 ◽  
Vol 97 (9) ◽  
pp. 1095-1109 ◽  
Author(s):  
Jaison D. Cucarián ◽  
Jenny P. Berrío ◽  
Cristiano Rodrigues ◽  
Mariana Zancan ◽  
Márcia R. Wink ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Physical Exercise ◽  
Rat Model ◽  
Male Rat ◽  
Motor Disturbances
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