scholarly journals Potential Role of Brain-Derived Neurotrophic Factor and Dopamine Receptor D2 Gene Variants as Modifiers for the Susceptibility and Clinical Course of Wilson’s Disease

2018 ◽  
Vol 20 (3) ◽  
pp. 401-408 ◽  
Author(s):  
Shubhrajit Roy ◽  
Prosenjit Pal ◽  
Sampurna Ghosh ◽  
Sreyashi Bhattacharya ◽  
Shyamal Kumar Das ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Neurotrophic Factor ◽  
Potential Role ◽  
Wilson’S Disease ◽  
Clinical Course ◽  
Brain Derived Neurotrophic Factor ◽  
Wilson's Disease ◽  
Gene Variants ◽  
Dopamine Receptor D2

The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain

2012 ◽  
Vol 39 (1) ◽  
pp. 96-101 ◽  
Author(s):  
Gwyneth C.M. Zai ◽  
Clement C.H. Zai ◽  
Nabilah I. Chowdhury ◽  
Arun K. Tiwari ◽  
Renan P. Souza ◽  
...  
Keyword(s):  
Weight Gain ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Gene Variants ◽  
Bdnf Gene

Brain-Derived Neurotrophic Factor: The Neurotrophin Hypothesis of Psychopathology

CNS Spectrums ◽  
2008 ◽  
Vol 13 (11) ◽  
pp. 945-949 ◽  
Author(s):  
Dan J. Stein ◽  
Willie M.U. Daniels ◽  
Jonathan Savitz ◽  
Brian H. Harvey
Keyword(s):  
Synaptic Plasticity ◽  
Brain Imaging ◽  
Neurotrophic Factor ◽  
Clinical Studies ◽  
Neuropsychiatric Disorders ◽  
Brain Derived Neurotrophic Factor ◽  
Therapeutic Interventions ◽  
Gene Variants ◽  
And Function

ABSTRACTWhile monoaminergic hypotheses of psychopathology remain popular, there has been growing interest in the role of neurotrophins in neuropsychiatric disorders. Basic laboratory work has documented the importance of neurotrophins in neuronal survival and synaptic plasticity, and a range of clinical studies has provided analogous evidence of their role in neuropathology. Work on gene variants in brain-derived neurotrophic factor, and associated changes in structural and function brain imaging, have further contributed to our understanding of this area. Much remains to be done to delineate fully the relevant mechanisms by which brain-derived neurotrophic factor and other neurotrophins contribute to psychopathology, and to develop targeted therapeutic interventions. Nevertheless, the neurotrophin hypothesis has already given impetus to a range of valuable research.

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