Pituitary-adrenal axis and peripheral cortisol metabolism in obese patients

Endocrine ◽  
2020 ◽  
Vol 69 (2) ◽  
pp. 386-392 ◽  
Author(s):  
Filippo Ceccato ◽  
Laura Lizzul ◽  
Mattia Barbot ◽  
Carla Scaroni
Keyword(s):  
Obese Patients ◽  
Cortisol Metabolism ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

IMPAIRMENT OF THE PITUITARY-ADRENAL AXIS FOLLOWING PROLONGED THERAPY WITH CORTICOTROPHIN

1970 ◽  
Vol 65 (4) ◽  
pp. 608-616 ◽  
Author(s):  
M. J. Levell ◽  
S. R. Stitch ◽  
M. J. Noronha
Keyword(s):  
Multiple Sclerosis ◽  
Adrenal Function ◽  
Withdrawal Symptoms ◽  
Prolonged Therapy ◽  
Adrenal Axis ◽  
Lysine Vasopressin ◽  
Subsequent Response ◽  
Pituitary Adrenal Axis

ABSTRACT Pituitary-adrenal function was tested in a group of 33 patients with multiple sclerosis who had been treated with corticotrophin for at least 1 year. Assessment was made by measuring the change in the plasma 11-hydroxycorticosteroid concentration following lysine vasopressin (LVP) administration. Ten patients showed abnormally small increases after LVP. Two of the 5 patients with the smallest increases still showed impairment 8 months later. The patients with no withdrawal symptoms had normal or nearly normal increases following LVP. There was an association between the concentration of 11-hydroxycorticosteroids immediately after withdrawal of ACTH and the subsequent response to LVP.

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