Colorectal Cancer Prevalence and Survival in Cuenca (Spain)

Colorectal Cancer Prevalence and Survival in Castilla La Mancha (Spain). A Pilot Study

10.21203/rs.3.rs-926142/v1 ◽

2021 ◽

Author(s):

Laura Valiente González ◽

Ricardo de Miguel Ibáñez ◽

Francisco Escribano Sotos

Keyword(s):

Colorectal Cancer ◽

Pilot Study ◽

Large Scale ◽

Cox Regression ◽

Epidemiological Studies ◽

Cancer Type ◽

Tumour Stage ◽

Cancer Prevalence ◽

La Mancha

Abstract Background: Colorectal cancer is the most commonly diagnosed cancer type and the second cause of cancer death in Spain. The primary risk factor for colorectal cancer is age, with 90% of all diagnosed patients aged over 50 years. Prognosis mainly depends on tumour stage. Aim: Conduct a pilot Colorectal Cancer prevalence and survival study in Cuenca (Spain) since there are almost no studies based on small populations. This is the first pilot study about survival in screening of colorectal cancer carried out in hospitals in Castilla La Mancha. Methods and Results: Retrospective descriptive cohort study was performed to include patients with colorectal cancer diagnosed by colonoscopy between May 2015 and April 2016, and who were followed up for 48 months. The study considered sociodemographic and clinical data of the patients. Survival curves were estimated using the Kaplan-Meier method. The proportional hazard rate associated with age, gender, stage and presence of metastasis was calculated using the Cox regression method. 57 patients were included in the study. The mean follow-up was 45.5 months. Ten patients died during the study, in seven cases the cause was colorectal cancer. The percentage of patients alive at 48-month follow-up were 82.4%. Conclusion: Colon cancer is a high-prevalence pathology, with adenocarcinoma being the most common histology. The results seem to indicate that it affects men more frequently, mortality rises with tumour stage at diagnosis and declines with use of chemotherapy. We present a pilot study that could justify large-scale epidemiological studies for the regional surveillance and evolution of colorectal cancer in Spain.

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Indeterminate pulmonary nodules among patients with new diagnosis of colorectal cancer: Prevalence and significance assessment

Journal of Current Oncology ◽

10.4103/jco.jco_28_20 ◽

2020 ◽

Vol 3 (2) ◽

pp. 62

Author(s):

NidalH Bokhary ◽

AbdulrahmanA Alghamdi ◽

FaisalA Alfaidi ◽

KhaledA Alfaidi ◽

NaifH Aljohani ◽

...

Keyword(s):

Colorectal Cancer ◽

Pulmonary Nodules ◽

Cancer Prevalence ◽

New Diagnosis

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The diagnostic value of a change in bowel habit for colorectal cancer within different age groups

United European Gastroenterology Journal ◽

10.1177/2050640619888040 ◽

2019 ◽

Vol 8 (2) ◽

pp. 211-219

Author(s):

Sofia M McCulloch ◽

Imran Aziz ◽

Annikka V Polster ◽

Andreas-Bernd Pischel ◽

Henrik Stålsmeden ◽

...

Keyword(s):

Colorectal Cancer ◽

Fast Track ◽

Diagnostic Yield ◽

Age Groups ◽

Diagnostic Value ◽

Bowel Habit ◽

Cancer Prevalence ◽

Alarm Symptom ◽

Alarm Features ◽

Over 40 Years

Background Change in bowel habit as a sole alarm symptom for colorectal cancer is disputed. Objective We investigated the diagnostic value of change in bowel habit for colorectal cancer, particularly as a single symptom and within different age groups. Methods This retrospective cohort study examined colorectal cancer fast track referrals and outcomes across four Swedish hospitals (April 2016–May 2017). Entry criteria constituted one or more of three alarm features: anaemia, visible rectal bleeding, or change in bowel habit for more than 4 weeks in patients over 40 years of age. Patients were grouped as having only change in bowel habit, change in bowel habit plus anaemia/bleeding or anaemia/bleeding only. Results Of 628 patients, 22% were diagnosed with colorectal cancer. There were no cases of colorectal cancer in the only change in bowel habit group under 55 years, while this was 6% for 55–64 years, 8% for 65–74 years and 14% for 75 years and older. Among subjects under 55 years, 2% with anaemia/bleeding had colorectal cancer, this increased to 34% for 55 years and older ( P < 0.0001). Change in bowel habit plus anaemia/bleeding gave a colorectal cancer prevalence of 16% in under 55 years and increased to 30% for 55 years and older ( P = 0.07). Conclusion Change in bowel habit as the only alarm feature has a low diagnostic yield for colorectal cancer in patients under 55 years.

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Colorectal cancer prevalence and risk factors among the uninsured of Tampa Bay: A free clinic study.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.4_suppl.61 ◽

2020 ◽

Vol 38 (4_suppl) ◽

pp. 61-61

Author(s):

Ethan Song ◽

Artish Patel ◽

Justin Swanson ◽

Alexandra Aponte ◽

Madeline MacDonald ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Inflammatory Bowel Disease ◽

Smoking Status ◽

Tampa Bay ◽

Free Clinics ◽

Uninsured Patients ◽

Cancer Prevalence ◽

History Of ◽

Inflammatory Bowel

61 Background: Uninsured patients with low socioeconomic status are at higher risk for developing colorectal cancer. There is limited quantifiable data regarding risk factors and prevalence of colorectal cancer in this vulnerable population. The purpose of this study is to assess the risk factors for colorectal cancer in the low income and uninsured patient population across nine free clinics around Tampa Bay, Florida. Methods: An IRB-approved manually extracted retrospective query of several medical record systems from nine free clinics in the Tampa Bay area in 2017 revealed 1,836 (36.1%) of 5,076 total patients who are over 50 years old. Patient demographics, weight, smoking status, alcohol use, type 2 diabetes status, inflammatory bowel disease and colorectal cancer prevalence were also extracted and analyzed. Results: Among patients over 50, the majority of patients were female (n = 1073, 58.4%) and of Hispanic ethnicity (n = 752, 41.0%). Of the 1,349 patients who reported their smoking status, 213 (15.8%) were active smokers and 218 (16.2%) were past smokers, with a mean 16.3 (SD = 15.5) pack year history. Of the 1,124 patients who reported their history of alcohol consumption, 217 (19.3%) were current consumers and 40 (3.6%) were past consumers. The average BMI of patients over 50 years was 30.2 (SD = 6.9), with 558 (30.4%) cases of diabetes. Eleven patients (0.6%) had a history of inflammatory bowel disease. The prevalence of documented colorectal cancer in this sample was 0.6% (n = 11) in our sample population. Conclusions: There is a high prevalence of risk factors for colorectal cancer in this sample of uninsured patients but a lower reported prevalence of colorectal cancer compared to the general population. Additionally, many known risk factors for colorectal cancer, such as diet, physical activity, or family history, are not routinely documented by free clinics. As these clinics provide opportune points of primary care, this baseline data should prompt more attention to colorectal screening and risk factor modification in this vulnerable population.

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