A discussion of serum albumin level in advanced-stage hepatocellular carcinoma: a medical oncologist’s perspective

2014 ◽  
Vol 31 (11) ◽  
Author(s):  
Ozgur Tanriverdi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Advanced Stage

Prognostic factors in aggressive malignant lymphomas: description and validation of a prognostic index that could identify patients requiring a more intensive therapy. The Groupe d'Etudes des Lymphomes Agressifs.

1991 ◽  
Vol 9 (2) ◽  
pp. 211-219 ◽  
Author(s):  
B Coiffier ◽  
C Gisselbrecht ◽  
J M Vose ◽  
H Tilly ◽  
R Herbrecht ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Overall Survival ◽  
Prognostic Factors ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Bone Marrow Involvement ◽  
Prognostic Index ◽  
Albumin Level ◽  
Advanced Stage ◽  
Low Serum

The objectives of this study were to determine prognostic factors for response to treatment, freedom-from-relapse (FFR) survival, and overall survival of 737 aggressive malignant lymphoma patients treated with the doxorubicin, cyclophosphamide, vindesine, bleomycin, methylprednisolone, methotrexate with leucovorin, ifosfamide, etoposide, asparaginase, and cytarabine (LNH-84) regimen; to construct a prognostic index with factors isolated by multivariate analyses; and to validate this prognostic index with another set of patients. Complete response (CR) was reached in 75% of LNH-84 patients, and 30% of them relapsed. With a median follow-up of 36 months, median FFR survival and median overall survival were not reached. Low serum albumin level, high tumoral mass, weight loss, bone marrow involvement, greater than or equal to 2 extranodal sites, and increased lactic dehydrogenase (LDH) level were associated with a low response rate. Advanced stage, increased LDH level, and nonlarge-cell histologic subtypes (diffuse mixed, lymphoblastic, and small non-cleaved) were statistically associated with a high relapse rate and short FFR survival. Increased LDH level, low serum albumin level, tumoral mass larger than 10 cm, greater than or equal to 2 extranodal sites, advanced stage, and age older than 65 years were statistically associated with short overall survival. Four of these parameters, namely, LDH level, stage, number of extranodal sites, and tumoral mass, were put together to construct a prognostic index. This index partitioned LNH-84 patients into three subgroups of good, intermediate, and poor prognosis (P less than .00001): CR rates of 93%, 83%, and 61%; relapse rates of 12%, 25%, and 45%; 3-year FFR survival of 87%, 73%, and 53%, and 3-year survival of 88%, 71%, and 41%, respectively. This prognostic index was applied to a test set of patients: 155 patients treated on protocols of the Nebraska Lymphoma Study Group. Using this index, these patients had 3-year FFR survival of 70%, 40%, and 22% (P = .0002) and 3-year survival of 79%, 52%, and 31% (P = .005). In patients with aggressive lymphomas, this simple prognostic index could distinguish between patients requiring intensive treatment such as autologous bone marrow transplantation in first complete remission and those who could be treated with standard regimens.

scholarly journals Exploring the malnutrition status and impact of total parenteral nutrition on the outcome of patients with advanced stage ovarian cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xin Yan ◽  
Sanyuan Zhang ◽  
Junmei Jia ◽  
Jiaolin Yang ◽  
Yilai Song ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Parenteral Nutrition ◽  
Serum Albumin ◽  
Total Parenteral Nutrition ◽  
Cancer Patients ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Cancer Type ◽  
Advanced Stage ◽  
Hospitalization Period

Abstract Background Ovarian cancer is a common cancer type in women and is often associated with onset of malnutrition. Total parenteral nutrition (TPN) is a nutritional intervention method that has been reported to have controversial effect on cancer patients. In the present retrospective study, we sought to explore the prevalence of malnutrition assessed by the Nutritional Risk Index (NRI) and its association with survival in advanced stage ovarian cancer patients. We also compared the post-operative outcome of the malnourished patients treated with either TPN or conservative management. Results A total of 415 patients with advanced stage ovarian cancer were separated into 4 nutrition groups based on the NRI scores. We found that a number of factors were significantly different among the 4 nutrition groups, including age, serum albumin level, BMI and NRI; among which serum albumin level and NRI were identified to be independent predictors of progression-free and overall survival. In the moderately and severely malnourished patients, those who were treated with TPN had significantly shorter hospitalization period, lower serum albumin level and lower BMI after surgery. In addition, serum albumin level, use of TPN and number of patients with complications were closely related to the hospital stay duration. Conclusion Malnutrition status is closely associated with survival of advanced stage ovarian cancer patients. These patients may benefit from TPN treatment for reduced hospitalization, especially with the onset of hypoalbuminemia.

scholarly journals Prognostic scoring system for metastatic spine tumors derived from hepatocellular carcinoma

2020 ◽  
Vol 28 (1) ◽  
pp. 230949901989916 ◽  
Author(s):  
Hiroshi Uei ◽  
Yasuaki Tokuhashi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Life Expectancy ◽  
Serum Albumin ◽  
General Condition ◽  
Scoring System ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Survival Times ◽  
Spine Tumors ◽  
Pugh Class

Purpose: The prognosis of hepatocellular carcinoma (HCC) has recently improved, and so clinicians have greater opportunity to treat HCC-derived spinal metastases. Therefore, predicting life expectancy is important for determining the optimal treatment strategy for such tumors. This study aimed to investigate the prognostic factors for HCC-derived metastatic spine tumors and to develop a scoring system for predicting life expectancy in such cases. Methods: The posttreatment survival time and factors that might influence it were investigated in 62 patients with HCC-derived metastatic spine tumors who were treated at our department (surgery: 27 patients and conservative treatment: 35 patients), and a prognostic scoring system for predicting life expectancy was developed by combining the factors that significantly influenced survival. Results: In the univariate analyses, sex, the patient’s general condition, the presence/absence of major internal organ metastasis, the total revised Tokuhashi score, the serum albumin level, Child-Pugh class, spinal surgery, and bone-modifying agent (BMA) treatment were found to influence the posttreatment survival time. These factors were subjected to multivariate analysis, and a novel scoring system for predicting life expectancy based on the patient’s general condition, the serum albumin level (or Child-Pugh class), and BMA treatment was developed. In the retrospective analysis, the concordance rate between the patients’ life expectancy and actual survival times was 90.3%. Conclusion: The patient’s general condition, the serum albumin level (or Child-Pugh class), and BMA treatment influenced the posttreatment survival times of patients with HCC-derived metastatic spine tumors. A prognostic scoring system based on these factors was proposed.

scholarly journals Geriatric nutritional risk index predicts prognosis in hepatocellular carcinoma after hepatectomy: a propensity score matching analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroki Kanno ◽  
Yuichi Goto ◽  
Shin Sasaki ◽  
Shogo Fukutomi ◽  
Toru Hisaka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Propensity Score ◽  
Serum Albumin ◽  
Propensity Score Matching ◽  
Serum Albumin Level ◽  
Risk Index ◽  
Albumin Level ◽  
Nutritional Risk ◽  
Geriatric Nutritional Risk Index ◽  
Nutritional Risk Index

AbstractThe geriatric nutritional risk index (GNRI) is widely used for nutritional assessment in older inpatients and is associated with postoperative complications and cancer prognosis. We investigated the use of GNRI to predict long-term outcomes in hepatocellular carcinoma of all etiologies after hepatectomy. Overall, 346 patients were examined after propensity score matching. We dichotomized the GNRI score into high GNRI (> 98: N = 173) and low GNRI (≤ 98: N = 173) and evaluated recurrence-free survival (RFS) and overall survival (OS) between both groups. Clinicopathological characteristics between the low- and high-GNRI groups were similar after propensity score matching except for the components of the GNRI score (body mass index and serum albumin level), Child–Pugh score (comprising serum albumin level), and preoperative alpha-fetoprotein level (p < 0.0001, p < 0.0001, p = 0.0030, and p = 0.0007, respectively). High GNRI was associated with significantly better RFS and OS (p = 0.0003 and p = 0.0211, respectively; log-rank test). Multivariate analysis revealed that GNRI is an independent prognostic factor of RFS and OS (low vs. high; hazard ratio [HR], 1.8284; 95% confidence interval [CI] 1.3598–2.4586; p < 0.0001, and HR, 1.5452; 95% CI 1.0345–2.3079; p = 0.0335, respectively). GNRI is an objective, inexpensive, and easily calculated assessment tool for nutritional status and can predict prognosis of hepatocellular carcinoma after hepatectomy.

scholarly journals Association of Low Serum Albumin Level with Higher Hepatocellular Carcinoma Recurrence in Patients with Hepatitis B Virus Pre-S2 Mutant after Curative Surgical Resection

2021 ◽  
Vol 10 (18) ◽  
pp. 4187
Author(s):  
Long-Bin Jeng ◽  
Tsai-Chung Li ◽  
Shih-Chao Hsu ◽  
Wen-Ling Chan ◽  
Chiao-Fang Teng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Albumin ◽  
Surgical Resection ◽  
Serum Albumin Level ◽  
Gene Segment ◽  
Albumin Level ◽  
Clinicopathological Factors ◽  
B Virus ◽  
Hcc Recurrence ◽  
Low Serum

Hepatocellular carcinoma (HCC) is, globally, one of the most prevalent and deadly human cancers; despite curative surgical resection, its high recurrence rate after surgery remains a large threat, resulting in poor patient survival. The hepatitis B virus (HBV) pre-S2 mutant that harbors deletions spanning the pre-S2 gene segment has emerged as an important oncoprotein for HCC development and a valuable prognostic biomarker for HCC recurrence; however, its relationship with clinicopathological factors is largely unexplored. In this study, the correlation of the deletion spanning the pre-S2 gene segment with clinicopathological factors and the association of such correlation with HCC recurrence after curative surgical resection were examined in HBV-related HCC patients. Inverse correlation between serum albumin level and the deletion spanning the pre-S2 gene segment was identified. HCC patients with the presence of the deletion spanning the pre-S2 gene segment and a low serum albumin level were associated with higher HCC recurrence than patients with either factor alone or neither factor were. Moreover, a combination of the serum albumin level and the deletion spanning the pre-S2 gene segment exhibited better performance than that of either factor alone in predicting HCC recurrence. Collectively, this study shows an association of low serum albumin level with pre-S2 mutant-positive HCC patients, and validates the prognostic value of this association in identifying patients with higher HCC recurrence after curative surgical resection.

Serum albumin level is a notable profiling factor for non-B, non-C hepatitis virus-related hepatocellular carcinoma: A data-mining analysis

2013 ◽  
Vol 44 (8) ◽  
pp. 837-845 ◽  
Author(s):  
Shingo Yamada ◽  
Atsushi Kawaguchi ◽  
Takumi Kawaguchi ◽  
Nobuyoshi Fukushima ◽  
Ryoko Kuromatsu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Data Mining ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Hepatitis Virus ◽  
Albumin Level ◽  
Data Mining Analysis

scholarly journals Geriatric Nutritional Risk Index Predicts Prognosis in Hepatocellular Carcinoma After Hepatectomy: A Propensity Score Matching Analysis

2021 ◽  
Author(s):  
Hiroki Kanno ◽  
Yuichi Goto ◽  
Shin Sasaki ◽  
Shogo Fukutomi ◽  
Toru Hisaka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Propensity Score ◽  
Serum Albumin ◽  
Propensity Score Matching ◽  
Serum Albumin Level ◽  
Risk Index ◽  
Albumin Level ◽  
Nutritional Risk ◽  
Geriatric Nutritional Risk Index ◽  
Nutritional Risk Index

Abstract The geriatric nutritional risk index (GNRI) is widely used for nutritional assessment in older inpatients and was recently reported to be associated with postoperative complications and cancer prognosis. We investigated the use of the GNRI to predict long-term outcomes in hepatocellular carcinoma of all etiologies after hepatectomy. 358 patients were reviewed after propensity score matching. We dichotomized the GNRI score into high GNRI (> 98: N = 179) and low GNRI (≤ 98: N = 179) and evaluated recurrence-free survival (RFS) and overall survival (OS) between the two groups. Clinicopathological characteristics between the low- and high-GNRI groups were similar after propensity score matching except for the components of the GNRI score (body mass index and serum albumin level), Child–Pugh score (consisting serum albumin level), and preoperative alpha-fetoprotein level (p < .0001, p < .0001, p = 0.0060, and p = 0.0049, respectively). A high GNRI was associated with significantly better RFS and OS (p = 0.0001 and p = 0.0055, respectively; log-rank test). Multivariate analysis revealed that GNRI is an independent prognostic factor of RFS and OS (low vs. high; HR, 1.8670; 95%CI, 1.4011–2.4880; p < .0001, HR, 1.7270; 95% CI, 1.1640–2.5623; p = 0.0066, respectively). The GNRI is an objective, inexpensive, and easily calculated assessment tool for nutritional status and can predict prognosis in hepatocellular carcinoma after hepatectomy.

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