scholarly journals Abnormal Mitochondrial Dynamics—A Novel Therapeutic Target for Alzheimer's Disease?

2010 ◽  
Vol 41 (2-3) ◽  
pp. 87-96 ◽  
Author(s):  
Bo Su ◽  
Xinglong Wang ◽  
David Bonda ◽  
Gorge Perry ◽  
Mark Smith ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Mitochondrial Dynamics ◽  
Novel Therapeutic

P4-241: Pathogenesis of intracellular amyloid beta-protein 42 and P53: A novel therapeutic target in Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S588-S588
Author(s):  
Yasumasa Ohyagi ◽  
Katsue Miyoshi ◽  
Ma Linqing ◽  
Kyoko Motomura ◽  
Takeshi Tabira ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Therapeutic Target ◽  
Amyloid Beta Protein ◽  
Novel Therapeutic

scholarly journals Binding and Transport of Amyloid-β by P-Glycoprotein: A Novel Therapeutic Target in Alzheimer's Disease

2019 ◽  
Vol 116 (3) ◽  
pp. 427a-428a
Author(s):  
Hope Holt ◽  
Elizabeth Moore ◽  
Madeline Riese ◽  
Michelle Faucett ◽  
Francisco Gonzalez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Amyloid Β ◽  
P Glycoprotein ◽  
Novel Therapeutic

P4-254: The apolipoprotein E/Aβ interaction as a novel therapeutic target for Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S591-S591
Author(s):  
Martin J. Sadowski ◽  
Joanna Pankiewicz ◽  
Henrieta Scholtzova ◽  
Hueizhi Wu ◽  
Frances Prelli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Therapeutic Target ◽  
Novel Therapeutic

scholarly journals Exosomes: a novel therapeutic target for Alzheimer’s disease?

2018 ◽  
Vol 13 (5) ◽  
pp. 930 ◽  
Author(s):  
Zhi-You Cai ◽  
Zun-Yu Ke ◽  
Ming Xiao ◽  
SohelH Quazi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Novel Therapeutic

scholarly journals Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

2018 ◽  
Vol 46 (4) ◽  
pp. 891-909 ◽  
Author(s):  
Ruby Macdonald ◽  
Katy Barnes ◽  
Christopher Hastings ◽  
Heather Mortiboys
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Therapeutic Target ◽  
Mitochondrial Dynamics ◽  
Central Mechanism ◽  
Phenotypic Screening ◽  
Mitochondrial Abnormalities

Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence for mitochondrial abnormalities in the two most common neurodegenerative diseases, Parkinson's disease and Alzheimer's disease. In addition, we discuss the main strategies which have been explored in these diseases to target the mitochondria for therapeutic purposes, focusing on mitochondrially targeted antioxidants, peptides, modulators of mitochondrial dynamics and phenotypic screening outcomes.

scholarly journals A Toxic Conformer of Aβ42 with a Turn at 22–23 is a Novel Therapeutic Target for Alzheimer’s Disease

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Naotaka Izuo ◽  
Chihiro Kasahara ◽  
Kazuma Murakami ◽  
Toshiaki Kume ◽  
Masahiro Maeda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Novel Therapeutic

Roles of p75NTR in the pathogenesis of Alzheimer's disease: A novel therapeutic target

2011 ◽  
Vol 82 (10) ◽  
pp. 1500-1509 ◽  
Author(s):  
Fan Zeng ◽  
Jian-Jun Lu ◽  
Xin-Fu Zhou ◽  
Yan-Jiang Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Novel Therapeutic

scholarly journals Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

2010 ◽  
Vol 177 (3) ◽  
pp. 1422-1435 ◽  
Author(s):  
Maya K. Desai ◽  
Michael A. Mastrangelo ◽  
Deborah A. Ryan ◽  
Kelly L. Sudol ◽  
Wade C. Narrow ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Novel Therapeutic
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