Hypoxic Preconditioning Attenuates Neuronal Cell Death by Preventing MEK/ERK Signaling Pathway Activation after Transient Global Cerebral Ischemia in Adult Rats

2013 ◽  
Vol 48 (1) ◽  
pp. 109-119 ◽  
Author(s):  
Lixuan Zhan ◽  
Hongxin Yan ◽  
Huarong Zhou ◽  
Weiwen Sun ◽  
Qinghua Hou ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Signaling Pathway ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Erk Signaling ◽  
Global Cerebral Ischemia ◽  
Adult Rats ◽  
Transient Global Cerebral Ischemia ◽  
Pathway Activation

scholarly journals Black Rice (Oryza sativa L ., Poaceae) Extract Reduces Hippocampal Neuronal Cell Death Induced by Transient Global Cerebral Ischemia in Mice

2018 ◽  
Vol 27 (2) ◽  
pp. 129-138 ◽  
Author(s):  
Sun-Nyoung Hwang ◽  
Jae-Cheon Kim ◽  
Mohammad Iqbal Hossain Bhuiyan ◽  
Joo Youn Kim ◽  
Ji Seon Yang ◽  
...  
Keyword(s):  
Cell Death ◽  
Oryza Sativa ◽  
Cerebral Ischemia ◽  
Oryza Sativa L ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Global Cerebral Ischemia ◽  
Black Rice ◽  
Transient Global Cerebral Ischemia

scholarly journals Resveratrol modulates the Akt/GSK-3β signaling pathway in a middle cerebral artery occlusion animal model

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Dong-Ju Park ◽  
Ju-Bin Kang ◽  
Fawad-Ali Shah ◽  
Phil-Ok Koh
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Middle Cerebral Artery ◽  
Signaling Pathway ◽  
Neuroprotective Effect ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Artery Occlusion ◽  
Gsk 3Β ◽  
Cerebral Artery Occlusion

Abstract Cerebral ischemia is a major cause of neurodegenerative disease. It induces neuronal vulnerability and susceptibility, and leads to neuronal cell death. Resveratrol is a polyphenolic compound that acts as an anti-oxidant. It exerts a neuroprotective effect against focal cerebral ischemic injury. Akt signaling pathway is accepted as a representative cell survival pathway, including proliferation, growth, and glycogen synthesis. This study investigated whether resveratrol regulates Akt/glycogen synthase kinase-3β (GSK-3β) pathway in a middle cerebral artery occlusion (MCAO)-induced ischemic brain injury. Adult male rats were intraperitoneally injected with vehicle or resveratrol (30 mg/kg) and cerebral cortices were isolated 24 h after MCAO. Neurological behavior test, corner test, brain edema measurment, and 2,3,5-triphenyltetrazolium chloride staining were performed to elucidate the neuroprotective effects of resveratrol. Phospho-Akt and phospho-GSK-3β expression levels were measured using Western blot analysis. MCAO injury led to severe neurobehavioral deficit, infraction, and histopathological changes in cerebral cortex. However, resveratrol treatment alleviated these changes caused by MCAO injury. Moreover, MCAO injury induced decreases in phospho-Akt and phospho-GSK-3β protein levels, whereas resveratrol attenuated these decreases. Phosphorylations of Akt and GSK-3β act as a critical role for the suppression of apoptotic cell death. Thus, our finding suggests that resveratrol attenuates neuronal cell death in MCAO-induced cerebral ischemia and Akt/GSK-3β signaling pathway contributes to the neuroprotective effect of resveratrol.

Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice

2011 ◽  
Vol 499 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Simone E. Thal ◽  
Changlian Zhu ◽  
Serge C. Thal ◽  
Klas Blomgren ◽  
Nikolaus Plesnila
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Global Cerebral Ischemia ◽  
Apoptosis Inducing Factor

scholarly journals Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia

2009 ◽  
Vol 1265 ◽  
pp. 138-147 ◽  
Author(s):  
Quan-Guang Zhang ◽  
Ruimin Wang ◽  
Dong Han ◽  
Yan Dong ◽  
Darrell W. Brann
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Global Cerebral Ischemia ◽  
Jnk Signaling ◽  
Rac1 Gtpase ◽  
Delayed Neuronal Cell Death
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