SNAP25 Gene Polymorphisms Protect Against Parkinson’s Disease and Modulate Disease Severity in Patients

2018 ◽  
Vol 56 (6) ◽  
pp. 4455-4463 ◽  
Author(s):  
Cristina Agliardi ◽  
Franca Rosa Guerini ◽  
Milena Zanzottera ◽  
Giulio Riboldazzi ◽  
Roberta Zangaglia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Gene Polymorphisms

Treadmill exercise tests in persons with Parkinson’s disease: responses and disease severity

2015 ◽  
Vol 28 (5) ◽  
pp. 1009-1014 ◽  
Author(s):  
Mon S. Bryant ◽  
George R. Jackson ◽  
Jyhgong Gabriel Hou ◽  
Elizabeth J. Protas
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Treadmill Exercise ◽  
Exercise Tests

Influence of Dopamine and Disease Severity on Primitive Reflexes in Parkinson’s Disease

1989 ◽  
Vol 29 (3) ◽  
pp. 141-144 ◽  
Author(s):  
Steven J. Huber ◽  
George W. Paulson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Primitive Reflexes

Stereopsis Deficits in Parkinson’s Disease and Their Clinical Implications

2020 ◽  
Author(s):  
Fang Ba ◽  
Tina T. Sang ◽  
Jaleh Fatehi ◽  
Wenjing He ◽  
Emanuel Mostofi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Severity ◽  
Rating Scale ◽  
Disease Status ◽  
Cognitive Status ◽  
Control Group ◽  
Motor Disorder ◽  
Healthy Control ◽  
Stereo Acuity

Abstract Background: Parkinson's disease (PD) is not exclusively a motor disorder. Among non-motor features, PD patients possess sensory visual dysfunctions. Stereopsis deficit can significantly impact patients' motor performance. However, it is not routinely tested, and its significance is under-investigated. Studying stereopsis using reliable 3D stimuli may help determine its implications in disease status in PD.The objective of the study is to investigate stereopsis abnormalities in PD with reliable and more physiological tools, and their correlation with indicators of PD severity. Methods: Twenty-four healthy control and 20 PD participants were first evaluated for visual acuity, visual field, contrast acuity, and stereoperception with 2D and Titmus stereotests, followed by the assessment with the 3D active shutter system. The correlation between stereopsis and disease severity, Unified Parkinson’s disease rating scale motor scores (UPDRS-III), levodopa equivalent daily dose (LEDD), course of disease and cognitive status were evaluated using univariate regression models. Results: Screening visual tests did not reveal any differences between PD and control group. With the 3D active shutter system, PD patients demonstrated significantly worse stereopsis (i.e p=0.002, 26 seconds of arc). There was a trend that UPDRS-III and LEDD negatively correlate with the stereo acuity, suggesting poorer stereoperception is related to disease severity. Preserved cognitive function correlated with more intact stereo acuity. Conclusion: With more reliable and physiological tools, PD patients exhibit poorer stereopsis. These deficits reflected PD motor and cognitive status. How stereopsis relates to gait, fall risks and navigation warrants more investigations in the future.

PARK2 and PARK7 Gene Polymorphisms as Risk Factors Associated with Serum Element Concentrations and Clinical Symptoms of Parkinson’s Disease

2019 ◽  
Vol 40 (3) ◽  
pp. 357-367
Author(s):  
Jaya Sanyal ◽  
Athira Anirudhan ◽  
Tapas Kumar Banerjee ◽  
Gautam Guha ◽  
Ramakrishnan Veerabathiran ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gene Polymorphisms ◽  
Clinical Symptoms ◽  
Factors Associated ◽  
Element Concentrations
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