scholarly journals Comparison of Functional Organ Preservation by Concomitant Boost Radiotherapy Versus Concurrent Chemoradiation in Locally Advanced Carcinoma of Larynx or Hypopharynx: A Prospective Randomized Study

2019 ◽  
Vol 71 (3) ◽  
pp. 360-366
Author(s):  
Abdul Hakim ◽  
Sushmita Ghoshal ◽  
Roshan Verma ◽  
Suresh C. Sharma
Keyword(s):  
Organ Preservation ◽  
Randomized Study ◽  
Locally Advanced ◽  
Concurrent Chemoradiation ◽  
Prospective Randomized Study ◽  
Advanced Carcinoma ◽  
Concomitant Boost ◽  
Boost Radiotherapy ◽  
Carcinoma Of Larynx

Pulsed-dose-rate vs. high-dose-rate intracavitary radiotherapy for locally advanced carcinoma of cervix: A prospective randomized study

Brachytherapy ◽  
2016 ◽  
Vol 15 (3) ◽  
pp. 327-332 ◽  
Author(s):  
Pavnesh Kumar ◽  
Daya Nand Sharma ◽  
Sunesh Kumar ◽  
Ajeet Kumar Gandhi ◽  
Goura Kishor Rath ◽  
...  
Keyword(s):  
Dose Rate ◽  
Randomized Study ◽  
Locally Advanced ◽  
High Dose Rate ◽  
Prospective Randomized Study ◽  
High Dose ◽  
Advanced Carcinoma ◽  
Carcinoma Of Cervix ◽  
Pulsed Dose Rate

scholarly journals A prospective randomized study comparing concurrent chemoradiation with weekly and 3 weekly cisplatin in locally advanced oropharyngeal carcinoma

2019 ◽  
Vol 08 (03) ◽  
pp. 178-182
Author(s):  
R. Nanda ◽  
Aradhana Katke ◽  
N. Suneetha ◽  
B. Thejaswini ◽  
Tanvir Pasha ◽  
...  
Keyword(s):  
Randomized Study ◽  
Locally Advanced ◽  
Tumour Response ◽  
Complete Response ◽  
Concurrent Chemotherapy ◽  
Concurrent Chemoradiation ◽  
Prospective Randomized Study ◽  
Oropharyngeal Carcinoma ◽  
Fisher Exact Test ◽  
Significant Difference

Abstract Introduction: The chemotherapy schedules with cytotoxic dose or weekly regimes are still challenging, weighing the benefits versus toxicities. This prospective randomized study is an attempt to assess the efficacy of two schedules of cisplatin in management of locally advanced HNSCC. Objectives: The objectives of this study was to evaluate tolerance, tumour response and toxicities of concurrent chemoradiation with cisplatin in weekly and three weekly regimes. Methods: Locally advanced oropharyngeal squamous cell carcinoma patients fit for concurrent chemoradiation with cisplatin 40 mg/m2 (weekly) and 100 mg/m2 (3 weekly) were randomized to Arm A and B concurrently with radiotherapy of 70Gy/35frs/7 weeks. Statistical Analysis: Chi-square/Fisher Exact test has been used to find the significance of study parameters on categorical scale between the groups. The statistical software SPSS 15.0 was used. Results: Between December 2010 and January 2013, 60 patients were enrolled. The median cycles of cisplatin in Arm-A was 5 and 2 in Arm-B. The complete response of 80.9% vs 75% and partial response of 14.3% vs 12.5% was observed in both arms respectively. There was no statistical difference in acute radiation and hematological toxicities between the two groups. With median follow up of 28 months, the 2 and 5 years overall survival was 55% and 58%; 41.6% and 32.3% in arms A and B respectively. Conclusion: In our study of locally advanced oropharyngeal carcinoma treated with radical radiotherapy comparing concurrent chemotherapy with cisplatin weekly vs 3 weekly had no significant difference in overall response, complete response and acute toxicities.

scholarly journals Comparison of concomitant boost radiotherapy against concurrent chemoradiation in locally advanced oropharyngeal cancers: A phase III randomised trial

2013 ◽  
Vol 107 (3) ◽  
pp. 317-324 ◽  
Author(s):  
Anupam Rishi ◽  
Sushmita Ghoshal ◽  
Roshan Verma ◽  
Arun S. Oinam ◽  
Vijai M. Patil ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Locally Advanced ◽  
Phase Iii ◽  
Concurrent Chemoradiation ◽  
Concomitant Boost ◽  
Boost Radiotherapy

Concomitant boost dose escalation plus large-field preoperative chemoradiation in locally advanced carcinoma of the uterine cervix: Results of a phase I study (LARA-CC-1)

2010 ◽  
Vol 118 (2) ◽  
pp. 128-133 ◽  
Author(s):  
Gabriella Macchia ◽  
Gabriella Ferrandina ◽  
Francesco Deodato ◽  
Valeria Ruggieri ◽  
Mariangela Massaccesi ◽  
...  
Keyword(s):  
Phase I ◽  
Dose Escalation ◽  
Uterine Cervix ◽  
Phase I Study ◽  
Locally Advanced ◽  
Preoperative Chemoradiation ◽  
Large Field ◽  
Advanced Carcinoma ◽  
Concomitant Boost ◽  
Boost Dose
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