Correlation of p53 expression with Clinical Presentation and Prognosis of Oral Squamous Cell Carcinoma Patients: A Pilot Study

2020 ◽  
Author(s):  
Abhay Vilas Deshmukh ◽  
Anupama Gupta ◽  
Akash Govinda Chaudhari ◽  
Nitin M. Gangane
Keyword(s):  
Squamous Cell Carcinoma ◽  
Pilot Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Presentation ◽  
P53 Expression

scholarly journals p53 immunohistochemical staining patterns in oral squamous cell carcinoma

2016 ◽  
Vol 6 (12) ◽  
pp. 1013-1017
Author(s):  
G Dundy ◽  
H Kumar ◽  
A Singh ◽  
A Chandarakant
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Oral Mucosa ◽  
Squamous Cell ◽  
P53 Protein ◽  
P Value ◽  
P53 Expression ◽  
Normal Oral Mucosa ◽  
Significant Difference

Background: Mutation of p53 gene is one of the most common events in oral carcinogenesis. Accumulation of p53 protein has also been detected in premalignant lesions.Materials and Methods:  This study included 40 biopsy samples, which were received in department of pathology, Sarojini Naidu Medical College, Agra, to ascertain p53 expression by immunohistochemically, in patients with oral squamous cell carcinomas and to correlate its expression with histological grade, different sites in oral cavity and tobacco intake/smoking habits.Results: Out of 40 biopsies of oral mucosa, 03 showed normal oral mucosa and 37 were diagnosed as squamous cell carcinoma (SCC), most patients were in 5th and 6th decade and majority (86.5%) of oral SCC were males with buccal mucosa being the most common site. There was a statistically significant difference in p53 expression between oral SCC and normal oral mucosa (p value <0.05). Of total 37 cases, 12 cases were well differentiated type, 16 moderately differentiated and 09 of poorly differentiated type of SCC. In each category, about two thirds were positive for p53 staining. Out of total 37 cases of oral SCC, 64.9% were positive and 35.1% were negative for p53 expression, 34 cases had positive history of tobacco intake/smoking habits, of which 23 cases were positive while 11 cases were negative for p53 staining.Conclusion: Abnormal p53 protein was detected in 64.9% of oral squamous cell carcinoma, but not in normal oral mucosa. p53 expression was associated with malignant transformation of oral mucosa. 

In oral squamous cell carcinoma, high FAK expression is correlated with low P53 expression

2012 ◽  
Vol 461 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Pablo Rosado ◽  
Paloma Lequerica-Fernández ◽  
Ignacio Peña ◽  
Laura Alonso-Durán ◽  
Juan C. de Vicente
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Expression

scholarly journals Biopsy type in oral squamous cell carcinoma patients in Western Australian Cancer Registry data (a pilot study)

2007 ◽  
Vol 52 (S4) ◽  
pp. S16-S16 ◽  
Author(s):  
AM Frydrych ◽  
LM Slack-Smith ◽  
T Threlfall ◽  
N Austin ◽  
GR Davies ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Pilot Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Registry ◽  
Squamous Cell ◽  
Registry Data ◽  
Cancer Registry Data ◽  
Western Australian

scholarly journals Mass spectrometry–based lipidomics of oral squamous cell carcinoma tissue reveals aberrant cholesterol and glycerophospholipid metabolism — A Pilot study

2020 ◽  
Vol 13 (10) ◽  
pp. 100807 ◽  
Author(s):  
Amy Dickinson ◽  
Mayank Saraswat ◽  
Sakari Joenväärä ◽  
Rahul Agarwal ◽  
Daniel Jyllikoski ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Squamous Cell Carcinoma ◽  
Pilot Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Tissue

Gene Expression Profile in Oral Squamous Cell Carcinoma: A Pilot Study

2005 ◽  
Vol 63 (6) ◽  
pp. 786-792 ◽  
Author(s):  
José Manuel Somoza-Martín ◽  
Abel García-García ◽  
Francisco Barros-Angueira ◽  
Eva Otero-Rey ◽  
María Torres-Español ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Pilot Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Squamous Cell

scholarly journals Connexin subtype expression during oral carcinogenesis: A pilot study in patients with oral squamous cell carcinoma

2015 ◽  
Vol 4 (2) ◽  
pp. 298-302 ◽  
Author(s):  
PHILLIPP BROCKMEYER ◽  
BERNHARD HEMMERLEIN ◽  
KLAUS JUNG ◽  
FLORIAN FIALKA ◽  
TOBIAS BRODMANN ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Pilot Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Carcinogenesis
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