Long-term results of a randomized partial irradiation trial compared to whole breast irradiation in the early stage and low-risk breast cancer patients after conservative surgery

Author(s):  
X. Li ◽  
J. Sanz ◽  
P. Foro ◽  
A. Martínez ◽  
M. Zhao ◽  
...  
2014 ◽  
Vol 22 (4) ◽  
pp. 1140-1145 ◽  
Author(s):  
Nicolas Ajkay ◽  
Abigail E. Collett ◽  
Erica V. Bloomquist ◽  
Edward J. Gracely ◽  
Thomas G. Frazier ◽  
...  

2005 ◽  
Vol 23 (9) ◽  
pp. 1934-1940 ◽  
Author(s):  
Jennifer R. Bellon ◽  
Steven E. Come ◽  
Rebecca S. Gelman ◽  
I. Craig Henderson ◽  
Lawrence N. Shulman ◽  
...  

Purpose The optimal integration of chemotherapy with radiation (RT) for patients with early-stage breast cancer remains uncertain. We present the long-term results of a prospective randomized trial to address this question. Patients and Methods Two hundred forty-four patients were randomly assigned after conservative breast surgery to receive 12 weeks of cyclophosphamide, doxorubicin, methotrexate, fluorouracil, and prednisone (CAMFP) before RT (CT-first) or after RT (RT-first). Median follow-up for surviving patients was 135 months. Results There were no significant differences between the CT-first and RT-first arms in time to any event, distant metastasis, or death. Sites of first failure were also not significantly different. Conclusion Among breast cancer patients treated with conservative surgery, there is no advantage to giving RT before adjuvant chemotherapy. However, this study does not have enough statistical power to rule out a clinically important survival benefit for either sequence.


2021 ◽  
Vol 161 ◽  
pp. S247
Author(s):  
B. Offersen ◽  
J. Alsner ◽  
H.M. Nielsen ◽  
E.H. Jacobsen ◽  
M.H. Nielsen ◽  
...  

Brachytherapy ◽  
2010 ◽  
Vol 9 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Richard B. Wilder ◽  
Lisa D. Curcio ◽  
Rajesh K. Khanijou ◽  
Martin E. Eisner ◽  
Jane L. Kakkis ◽  
...  

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