Flow and heat transfer of non-Newtonian fluid in porous media is an universal physical process in nature, industry and agriculture. With a certain concentration of HPAM aqueous solution (a typical power-law type non-Newtonian fluid) as the fluid medium, constructing the porous media skeleton model of orderly arrangement of spherical particles, the flow and heat transfer characteristics in three-dimensional orderly arrangement of porous media have been investigated numerically by using Fluent software. By employing the method of fluid-solid coupling subject to uniform heat flux, the effects of power law fluid rheological index, particle material, particle diameter and porosity on the flow and heat transfer characteristics are analyzed in detail. And also the concept of thermal efficiency is introduced to gain the comprehensive evaluation of its flow and heat transfer characteristics. The results show that the flow resistance decreases with the increase of the power-law index, particle diameter and porosity, and has nothing to do with the thermal conductivity coefficient of particles; while the local convection heat transfer coefficient increases with the increase of the power-law index and the thermal conductivity coefficient of particles, and decreases with the increase of particle diameter and porosity. The results can provide a theoretical basis for the flow and heat transfer mechanism of the power-law type non-Newtonian fluid flowing through the three-dimensional structured packed porous media of particles.