Electrospun curcumin loaded poly(lactic acid) nanofiber mat on the flexible crosslinked PVA/PEG membrane film: Characterization and in vitro release kinetic study

The purpose of this research was to isolate the smart biopolymer from the fruit pulp of Fragaria × ananassa (garden strawberry). We isolated natural fruit pulp to evaluate the potentiality of biopolymer in delivery of nanosized lamotrigine as an antiepileptic drug. Lamotrigine was nanosized by screening its nano-size particle by UV method. The nanosized lamotrigine was used for preparation of bionanoparticles (LF1-LF8) by sonication method. The isolated biopolymer was characterized for DSC, FTIR, NMR, Mass and Zeta particle size analysis. The obtained results confirm its polymeric nature in different analysis. The prepared bionanoparticles showed the release of lamotrigine in sustained manner over 36 hours. The release kinetic study was done by using the BIT-SOFT 1.12 software and T50% and T80%, r2 were calculated. All the formulation showed more than 99.78% drug release. The In-vitro release study of different formulations showed the % drug release from 90.92% to 99.78%. The different formulations were evaluated for the In-vitro release study and release kinetic was studied. The formulation LF5 was found to be the best formulation having T50% of 17 hours and T80% of 29 hours with r2 value of 0.9925. The best formulation LF5 showed up to 90.925% drug release over 36 hours. According to the release kinetic study, the best-fit model was found to be Koresmayer-Peppas and the mechanism of drug release was found to be anomalous transport. The results obtained from different evaluations like percentage entrapment efficiency, particle size, release study, kinetic studies and stability study revealed that isolated biopolymer has good potentiality to form bionanoparticles and it can be safely used as an alternative to synthetic and semisynthetic polymers for the preparation of lamotrigine loaded stable bionanoparticles

Download Full-text

Mechanism and in Vitro Release Kinetic Study of Sirolimus from a Biodegradable Polymeric Matrix Coated Cardiovascular Stent

Industrial & Engineering Chemistry Research ◽

10.1021/ie102163z ◽

2011 ◽

Vol 50 (16) ◽

pp. 9539-9549 ◽

Cited By ~ 49

Author(s):

Ankur Raval ◽

Jigisha Parikh ◽

Chhaya Engineer

Keyword(s):

Kinetic Study ◽

In Vitro Release ◽

Polymeric Matrix ◽

Release Kinetic ◽

Cardiovascular Stent ◽

Vitro Release

Download Full-text

Fabrication, Characterization, In Vitro Release, and Some Biological Activities of Eucalyptus Essential Oil Loaded Poly (Lactic Acid) Nanofibers

ACTA SCIENTIFIC MICROBIOLOGY ◽

10.31080/asmi.2020.04.0768 ◽

2021 ◽

Vol 4 (2) ◽

pp. 54-63

Author(s):

Hayfa Argui ◽

Salih Can Suner ◽

Çağdaş Deniz Periz ◽

Seyhan Ulusoy ◽

Mossadok Ben-Attia ◽

...

Keyword(s):

Lactic Acid ◽

Essential Oil ◽

Biological Activities ◽

In Vitro Release ◽

Poly Lactic Acid ◽

Vitro Release ◽

Eucalyptus Essential Oil

Download Full-text

Preparation and In Vitro Release Behaviors of Paclitaxel-Loaded Pluronic F87/Poly(Lactic Acid) Nanoparticle

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.989-994.102 ◽

2014 ◽

Vol 989-994 ◽

pp. 102-107

Author(s):

Zi Ling Li ◽

You Sheng Huang ◽

Xiang Yuan Xiong ◽

Yan Chun Gong ◽

Yu Ping Li

Keyword(s):

Lactic Acid ◽

In Vitro Release ◽

Bulk Polymerization ◽

Poly Lactic Acid ◽

Release Behavior ◽

Loading Efficiency ◽

Dialysis Method ◽

Good Biocompatibility ◽

Vitro Release

Pluronic F87/Poly (lactic acid) block copolymer (PLA-F87-PLA) was synthesized by bulk polymerization. Paclitaxel-loaded PLA-F87-PLA nanoparcticles were prepared by a dialysis method. The loading efficiency was determined by UV. The results showed that the loading efficiency of paclitaxel for PLA-F87-PLA nanoparticles was 69%. In vitro release behavior of paclitaxel-loaded PLA-F87-PLA nanoparticles was studied by HPLC. In vitro release behavior showed an initial rapid release followed by a slow release. The biocompatibility of nanoparticles was measured by MTT. The viability of paclitaxel-loaded PLA-F87-PLA nanoparticles was less than that of free paclitaxel. The results indicated that PLA-F87-PLA copolymer has good biocompatibility.

Download Full-text