Preparation and In Vitro Release Behaviors of Paclitaxel-Loaded Pluronic F87/Poly(Lactic Acid) Nanoparticle

2014 ◽  
Vol 989-994 ◽  
pp. 102-107
Author(s):  
Zi Ling Li ◽  
You Sheng Huang ◽  
Xiang Yuan Xiong ◽  
Yan Chun Gong ◽  
Yu Ping Li
Keyword(s):  
Lactic Acid ◽  
In Vitro Release ◽  
Bulk Polymerization ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Loading Efficiency ◽  
Dialysis Method ◽  
Good Biocompatibility ◽  
Vitro Release

Pluronic F87/Poly (lactic acid) block copolymer (PLA-F87-PLA) was synthesized by bulk polymerization. Paclitaxel-loaded PLA-F87-PLA nanoparcticles were prepared by a dialysis method. The loading efficiency was determined by UV. The results showed that the loading efficiency of paclitaxel for PLA-F87-PLA nanoparticles was 69%. In vitro release behavior of paclitaxel-loaded PLA-F87-PLA nanoparticles was studied by HPLC. In vitro release behavior showed an initial rapid release followed by a slow release. The biocompatibility of nanoparticles was measured by MTT. The viability of paclitaxel-loaded PLA-F87-PLA nanoparticles was less than that of free paclitaxel. The results indicated that PLA-F87-PLA copolymer has good biocompatibility.

scholarly journals Fabrication, Characterization, In Vitro Release, and Some Biological Activities of Eucalyptus Essential Oil Loaded Poly (Lactic Acid) Nanofibers

2021 ◽  
Vol 4 (2) ◽  
pp. 54-63
Author(s):  
Hayfa Argui ◽  
Salih Can Suner ◽  
Çağdaş Deniz Periz ◽  
Seyhan Ulusoy ◽  
Mossadok Ben-Attia ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Essential Oil ◽  
Biological Activities ◽  
In Vitro Release ◽  
Poly Lactic Acid ◽  
Vitro Release ◽  
Eucalyptus Essential Oil

New amoxicillin-poly(lactic acid)-based conjugates: synthesis and in vitro release of amoxicillin

2010 ◽  
Vol 60 (3) ◽  
pp. 398-404 ◽  
Author(s):  
Hélène Van Den Berghe ◽  
Xavier Garric ◽  
Michel Vert ◽  
Jean Coudane
Keyword(s):  
Lactic Acid ◽  
In Vitro Release ◽  
Poly Lactic Acid ◽  
Vitro Release

Electrospun curcumin loaded poly(lactic acid) nanofiber mat on the flexible crosslinked PVA/PEG membrane film: Characterization and in vitro release kinetic study

2017 ◽  
Vol 18 (12) ◽  
pp. 2349-2360 ◽  
Author(s):  
Leila Moradkhannejhad ◽  
Majid Abdouss ◽  
Nasser Nikfarjam ◽  
Saeedeh Mazinani ◽  
Pantea Sayar
Keyword(s):  
Lactic Acid ◽  
Kinetic Study ◽  
In Vitro Release ◽  
Poly Lactic Acid ◽  
Release Kinetic ◽  
Vitro Release

Preparation and In-vitro Evaluation of Fe3O4 Encapsulated by Chitosan Loaded Capecitabine Nanoparticles for the Treatment of Breast Cancer

2016 ◽  
Vol 6 (3) ◽  
Author(s):  
Shanmuganathan S. ◽  
Nigma S. ◽  
Anbarasan B. ◽  
Harika B.
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Polymer Concentration ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
In Vitro Evaluation ◽  
Sem Image ◽  
Therapeutic Molecules ◽  
Dialysis Method ◽  
Vitro Release

Nanoparticulate Carriers which is biodegradable, biocompatible and bio adhesive have significant feasible applications for administration of therapeutic molecules. The present study was aimed to formulate and optimise Capecitabine loaded Chitosan-Fe3O4 Nanoparticles and to study the in-vitro evaluation by sigma dialysis method. Capecitabine loaded chitosan – Fe3O4 nanoparticles batches with different ratios of drug: polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6) were prepared by ionic gelation method. Increase in polymer concentration increases the nanoparticle drug content. Entrapment efficiency was 60.12% with drug to polymer ratio F3 (1:3). In-vitro release was found to be 65.20% for 12 hrs. Capecitabine from chitosanFe3O4 nanoparticles SEM image reveals discrete spherical structure and particles with size range of 100-500nm. FTIR studies represent the functional groups present with no characteristics change in formulations. Samples stored at refrigerator conditions showed better stability compared with samples kept at other conditions during 8 weeks of storage.

Fabrication of curcumin-loaded whey protein microgels: Structural properties, antioxidant activity, and in vitro release behavior

LWT ◽  
2019 ◽  
Vol 103 ◽  
pp. 94-100 ◽  
Author(s):  
Mehdi Mohammadian ◽  
Maryam Salami ◽  
Shima Momen ◽  
Farhad Alavi ◽  
Zahra Emam-Djomeh
Keyword(s):  
Antioxidant Activity ◽  
Whey Protein ◽  
Structural Properties ◽  
In Vitro Release ◽  
Release Behavior ◽  
Vitro Release
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