Lutein-Loaded Solid Lipid Nanoparticles for Ocular Delivery: Statistical Optimization and Ex Vivo Evaluation

2021 ◽  
Author(s):  
Sunny Shah ◽  
Brijesh Bhanderi ◽  
Moinuddin Soniwala ◽  
Jayant Chavda
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Ex Vivo ◽  
Lipid Nanoparticles ◽  
Statistical Optimization ◽  
Ocular Delivery ◽  
Solid Lipid

Quercetin delivery to porcine cornea and sclera by solid lipid nanoparticles and nanoemulsion

RSC Advances ◽  
2015 ◽  
Vol 5 (122) ◽  
pp. 100923-100933 ◽  
Author(s):  
Chi-Hsien Liu ◽  
Yun-Chun Huang ◽  
Jhe-Wei Jhang ◽  
Yu-Hong Liu ◽  
Wei-Chi Wu
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Ocular Delivery ◽  
Solid Lipid ◽  
Porcine Cornea

Two potential nanocarriers including nanoemulsions and solid lipid nanoparticles have been demonstrated as vehicles for quercetin encapsulation and ocular delivery.

Development and characterization of itraconazole-loaded solid lipid nanoparticles for ocular delivery

2014 ◽  
Vol 20 (4) ◽  
pp. 458-464 ◽  
Author(s):  
Biswaranjan Mohanty ◽  
Dipak K. Majumdar ◽  
Sagar K. Mishra ◽  
Amulya K. Panda ◽  
Soma Patnaik
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Ocular Delivery ◽  
Solid Lipid

Effect of penetration enhancers and amorphization on transdermal permeation flux of raloxifene-encapsulated solid lipid nanoparticles: an ex vivo study on human skin

2019 ◽  
Vol 9 (6) ◽  
pp. 1383-1394 ◽  
Author(s):  
Krishna Kumar Patel ◽  
Shilpkala Gade ◽  
Md. Meraj Anjum ◽  
Sanjay Kumar Singh ◽  
Pralay Maiti ◽  
...  
Keyword(s):  
Human Skin ◽  
Solid Lipid Nanoparticles ◽  
Ex Vivo ◽  
Lipid Nanoparticles ◽  
Penetration Enhancers ◽  
Permeation Flux ◽  
Transdermal Permeation ◽  
Solid Lipid ◽  
Ex Vivo Study

scholarly journals Erratum to "Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles, in Vitro, Ex Vivo and in Vivo Characteristics"

2020 ◽  
Vol 11 (1) ◽  
pp. 204-204
Author(s):  
Solmaz Ghaffari ◽  
Faezeh Alihosseini ◽  
Seyed Mahdi Rezayat Sorkhabadi ◽  
Sepideh Arbabi Bidgoli ◽  
Seyyedeh Elaheh Mousavi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Solid Lipid Nanoparticles ◽  
Ex Vivo ◽  
Lipid Nanoparticles ◽  
Dosage Forms ◽  
Solid Lipid

LIPID NANOPARTICLES FOR TRANSDERMAL DELIVERY OF CELECOXIB: AN IN VITRO AND IN VIVO INVESTIGATION

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (08) ◽  
pp. 38-48
Author(s):  
S. V Shinde ◽  
S Nikam ◽  
P Raut ◽  
M. K. Ghag ◽  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Ex Vivo ◽  
Research Work ◽  
Lipid Nanoparticles ◽  
Inflammatory Activity ◽  
Promising Alternative ◽  
Solid Lipid ◽  
Anti Inflammatory

In the present research work, celecoxib (CXB) loaded solid lipid nanoparticles (SLNs) were prepared using the probe sonication method, wherein Glyceryl monostearate and Tween 80 were used as solid lipid and surfactant, respectively. To obtain the statistically optimized batch, 32 factorial design was applied. The optimized batch was characterized physicochemically and evaluated through DSC, SEM and XRD studies. The mean particle size of the optimized batch was found to be 135.41± 0.24 nm with a mean % entrapment efficiency of 80 ± 1.69%. The optimized batch was further lyophilized and dispersed into 1% w/v Carbopol 934P to form a gel. Prepared gel was further evaluated for in vitro drug release, occlusivity, ex vivo permeability, local toxicity, in vivo anti-inflammatory activity and accelerated stability study. The study resulted in stable, safe and prolonged anti-inflammatory activity with quick onset of action. Hence, celecoxib loaded solid lipid nanoparticles can be considered as promising alternative to conventional topical systems.

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