High Grade T1 Papillary Urothelial Bladder Cancer Shows Prominent Peritumoral Retraction Clefting

2017 ◽  
Vol 24 (3) ◽  
pp. 567-574 ◽  
Author(s):  
Tihana Džombeta ◽  
Božo Krušlin
Keyword(s):  
Bladder Cancer ◽  
High Grade ◽  
Urothelial Bladder Cancer ◽  
Urothelial Bladder ◽  
Retraction Clefting

scholarly journals Clinical outcomes in a cohort of patients with T1 high grade urothelial bladder cancer not receiving intravesical bacillus Calmette-Guerin: a 15 year experience

2018 ◽  
Vol 63 (1) ◽  
pp. 37
Author(s):  
S A S Goonewardena ◽  
U Jayarajah ◽  
S N Kuruppu ◽  
H M K B Herath ◽  
D M H Fernando ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Clinical Outcomes ◽  
High Grade ◽  
Bacillus Calmette Guerin ◽  
Urothelial Bladder Cancer ◽  
Urothelial Bladder

scholarly journals CCDC6 and USP7 expression levels suggest novel treatment options in high-grade urothelial bladder cancer

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Francesco Morra ◽  
Francesco Merolla ◽  
Daniela Criscuolo ◽  
Luigi Insabato ◽  
Riccardo Giannella ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Treatment Options ◽  
High Grade ◽  
Urothelial Bladder Cancer ◽  
Expression Levels ◽  
Novel Treatment ◽  
Urothelial Bladder

scholarly journals Endothelin-1 indicates unfavorable prognosis in primary high-grade non-muscle-invasive urothelial bladder cancer

2021 ◽  
Vol 93 (2) ◽  
pp. 143-147
Author(s):  
Lampros Mitrakas ◽  
Stavros Gravas ◽  
Foteini Karasavvidou ◽  
Ioannis Zachos ◽  
Anastasios Karatzas ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Progression Free Survival ◽  
High Grade ◽  
Urothelial Bladder Cancer ◽  
Free Survival ◽  
Endothelin 1 ◽  
Bcg Therapy ◽  
Urothelial Bladder ◽  
Muscle Invasive ◽  
A Prospective Study

Objective: To conduct a prospective study of the potential prognostic role of endothelin-1 (ET-1) in a cohort of primary high-grade non-muscle-invasive urothelial bladder cancer patients, who were treated with adjuvant intravesical Bacillus Calmette-Guérin (BCG). Material and methods: Patients with primary high-grade nonmuscle- invasive urothelial bladder cancer, who received postoperatively induction and maintenance BCG therapy, were prospectively included. Recurrence and progression were histologically proven. Immunohistochemical staining for ET-1 was assessed. Epidemiological, pathological and clinical parameters as well as the expression of ET-1 in tumor specimens were statistically analyzed for recurrence, progression, recurrence-free survival (RFS) and progression-free survival (PFS). Results: ET-1 associates significantly with recurrence (p = 0.000), progression (p = 0.000), RFS (p = 0.000) and PFS (p = 0.000). The patient’s age is also significant for recurrence (p = 0.003, OR = 1.273 95% CI: 1.086-1.492) and RFS (p = 0.013). Conclusions: ET-1 seems to deteriorate prognosis in patients suffering from primary high-grade non-muscle-invasive urothelial bladder cancer, who are treated with adjuvant BCG instillations. Furthermore, the patient’s age associates with an increased likelihood for recurrence.

Abstract 5120: The novel claudin-low molecular subtype of high-grade urothelial bladder cancer is highly immunogenic yet immunosuppressed

2016 ◽  
Author(s):  
Benjamin G. Vincent ◽  
William Kim ◽  
Jordan Kardos ◽  
Shengjie Chai ◽  
Joel Parker ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Molecular Subtype ◽  
High Grade ◽  
The Novel ◽  
Urothelial Bladder Cancer ◽  
Urothelial Bladder

scholarly journals Pure high-grade papillary urothelial bladder cancer: a luminal-like subgroup with potential for targeted therapy

2020 ◽  
Vol 43 (5) ◽  
pp. 807-819 ◽  
Author(s):  
Tician Schnitzler ◽  
Nadina Ortiz-Brüchle ◽  
Ursula Schneider ◽  
Isabella Lurje ◽  
Karolina Guricova ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Clinical Trials ◽  
Targeted Therapy ◽  
Targeted Therapies ◽  
Molecular Subtype ◽  
Genomic Alteration ◽  
High Grade ◽  
Urothelial Bladder Cancer ◽  
Non Invasive ◽  
Urothelial Bladder

Abstract Purpose Non-invasive high-grade (HG) bladder cancer is a heterogeneous disease that is characterized insufficiently. First-line Bacillus Calmette-Guérin instillation fails in a substantial amount of cases and alternative bladder-preserving treatments are limited, underlining the need to promote a further molecular understanding of non-invasive HG lesions. Here, we characterized pure HG papillary urothelial bladder cancer (pure pTa HG), a potential subgroup of non-invasive HG bladder carcinomas, with regard to molecular subtype affiliation and potential for targeted therapy. Methods An immunohistochemistry panel comprising luminal (KRT20, ERBB2, ESR2, GATA3) and basal (KRT5/6, KRT14) markers as well as p53 and FGFR3 was used to analyze molecular subtype affiliations of 78 pure pTa HG/papillary pT1(a) HG samples. In 66 of these, ERBB2 fluorescence in situ hybridization was performed. Additionally, targeted sequencing (31 genes) of 19 pTa HG cases was conducted, focusing on known therapeutic targets or those described to predict response to targeted therapies noted in registered clinical trials or that are already approved. Results We found that pure pTa HG/papillary pT1(a) HG lesions were characterized by a luminal-like phenotype associated with frequent (58% of samples) moderate to high ERBB2 protein expression, rare FGFR3 alterations on genomic and protein levels, and a high frequency (89% of samples) of chromatin-modifying gene alterations. Of note, 95% of pTa HG/papillary pT1 HG cases harbored at least one potential druggable genomic alteration. Conclusions Our data should help guiding the selection of targeted therapies for investigation in future clinical trials and, additionally, may provide a basis for prospective mechanistic studies of pTa HG pathogenesis.

scholarly journals High-grade urothelial bladder cancer in children: A case report and critical analysis of the literature

2016 ◽  
Vol 160 (4) ◽  
pp. 578-582 ◽  
Author(s):  
Milan Kral ◽  
Jaroslav Michalek ◽  
Jozef Skarda ◽  
Tomas Tichy ◽  
Oldrich Smakal ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Case Report ◽  
Critical Analysis ◽  
High Grade ◽  
Urothelial Bladder Cancer ◽  
Urothelial Bladder ◽  
Cancer In Children

scholarly journals MP08-19 PTA HIGH GRADE UROTHELIAL BLADDER CANCER: RECURRENCE, PROGRESSION PATTERN AND ROLE OF SECOND TURBT

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Anuj Deep Dangi ◽  
Ramani Manoj Kumar ◽  
Thomas Alex Kodiatte ◽  
Mahasampath Gowri ◽  
Santosh Kumar ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Recurrence ◽  
High Grade ◽  
Urothelial Bladder Cancer ◽  
Urothelial Bladder ◽  
Bladder Cancer Recurrence
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