The Reductive Amination of Carbonyl Compounds Using Native Amine Dehydrogenase from Laribacter hongkongensis

2021 ◽  
Vol 26 (3) ◽  
pp. 384-391
Author(s):  
Somin Lee ◽  
Hyunwoo Jeon ◽  
Pritam Giri ◽  
Uk-Jae Lee ◽  
Hyunsang Jung ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Reductive Amination ◽  
Laribacter Hongkongensis ◽  
Amine Dehydrogenase

One-Pot Reductive Amination of Carbonyl Compounds Using Sodium Borohydride–Amberlyst 15

2010 ◽  
Vol 40 (7) ◽  
pp. 951-956 ◽  
Author(s):  
Heshmatollah Alinezhad ◽  
Mahmood Tajbakhsh ◽  
Nastaran Mahdavi
Keyword(s):  
Sodium Borohydride ◽  
Carbonyl Compounds ◽  
Reductive Amination ◽  
One Pot ◽  
Amberlyst 15

Ambient-Temperature Synthesis of Primary Amines via Reductive Amination of Carbonyl Compounds

ACS Catalysis ◽  
2020 ◽  
Vol 10 (14) ◽  
pp. 7763-7772 ◽  
Author(s):  
Chao Xie ◽  
Jinliang Song ◽  
Manli Hua ◽  
Yue Hu ◽  
Xin Huang ◽  
...  
Keyword(s):  
Ambient Temperature ◽  
Carbonyl Compounds ◽  
Reductive Amination ◽  
Primary Amines ◽  
Temperature Synthesis

scholarly journals Economy Assessment for the Chiral Amine Production with Comparison of Reductive Amination and Transamination Routes by Multi-Enzyme System

Catalysts ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1451
Author(s):  
Heyu Huo ◽  
Guangxiao Yao ◽  
Shizhen Wang
Keyword(s):  
Reductive Amination ◽  
Nadh Oxidase ◽  
Glucose Dehydrogenase ◽  
Economic Assessment ◽  
Building Blocks ◽  
Unit Price ◽  
Chiral Amine ◽  
Process Comparison ◽  
Amine Dehydrogenase

Chiral amines are key building blocks for pharmaceuticals. Economic assessment of commercial potential of bioprocesses is needed for guiding research. Biosynthesis of (S)-α-methylbenzylamine (MBA) was selected as case study. For transamination route, transaminase coupled with glucose dehydrogenase and lactate dehydrogenase catalyzed the reaction with NADH (Nicotinamide adenine dinucleotide) regeneration. Amine dehydrogenase coupled with NADH oxidase, which catalyzed the reductive amination process. Comparison of biosynthesis cost by reductive amination and transamination routes was carried out. Economic assessment based on the framework of cost analysis and preliminary process information revealed that cost is greatly dependent on enzyme price. The results indicated that enhancing the activity of amine dehydrogenase by 4–5 folds can drop the unit price of reductive amination to $0.5–0.6/g, which make it competitive with transamination route.

Reductive Amination of Biobased Levulinic Acid to Unnatural Chiral γ-Amino Acid Using an Engineered Amine Dehydrogenase

2020 ◽  
Vol 8 (46) ◽  
pp. 17054-17061
Author(s):  
Rui-Feng Cai ◽  
Lei Liu ◽  
Fei-Fei Chen ◽  
Aitao Li ◽  
Jian-He Xu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Levulinic Acid ◽  
Reductive Amination ◽  
Amine Dehydrogenase

The effects of added ammonium chloride in the reductive amination of some carbonyl compounds over Ru and Pd catalysts

Tetrahedron ◽  
2005 ◽  
Vol 61 (8) ◽  
pp. 2105-2109 ◽  
Author(s):  
Tomoaki Ikenaga ◽  
Kumiko Matsushita ◽  
Junichi Shinozawa ◽  
Satoru Yada ◽  
Yuzuru Takagi
Keyword(s):  
Ammonium Chloride ◽  
Carbonyl Compounds ◽  
Reductive Amination ◽  
Pd Catalysts

Synthesis of tertiary amines by direct Brønsted acid catalyzed reductive amination

2020 ◽  
Vol 56 (61) ◽  
pp. 8691-8694
Author(s):  
Mohanad A. Hussein ◽  
An H. Dinh ◽  
Vien T. Huynh ◽  
Thanh Vinh Nguyen
Keyword(s):  
Carbonyl Compounds ◽  
Reductive Amination ◽  
Bronsted Acid ◽  
Tertiary Amines ◽  
Brønsted Acid ◽  
Triflic Acid ◽  
Brönsted Acid ◽  
Acid Catalyzed

Triflic acid efficiently promotes the reductive amination reactions of carbonyl compounds on a broad range of substrates.

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