scholarly journals The maternal folate hydrolase gene polymorphism is associated with neural tube defects in a high-risk Chinese population

2012 ◽  
Vol 8 (2) ◽  
pp. 191-197 ◽  
Author(s):  
Jin Guo ◽  
Hua Xie ◽  
Jianhua Wang ◽  
Huizhi Zhao ◽  
Fang Wang ◽  
...  
Keyword(s):  
High Risk ◽  
Gene Polymorphism ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population ◽  
Folate Hydrolase

scholarly journals The Maternal ITPK1 Gene Polymorphism Is Associated with Neural Tube Defects in a High-Risk Chinese Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86145 ◽  
Author(s):  
Zhen Guan ◽  
Jianhua Wang ◽  
Jin Guo ◽  
Fang Wang ◽  
Xiuwei Wang ◽  
...  
Keyword(s):  
High Risk ◽  
Gene Polymorphism ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population

Maternal PCMT1 gene polymorphisms and the risk of neural tube defects in a Chinese population of Lvliang high-risk area

Gene ◽  
2012 ◽  
Vol 505 (2) ◽  
pp. 340-344 ◽  
Author(s):  
Huizhi Zhao ◽  
Fang Wang ◽  
Jianhua Wang ◽  
Hua Xie ◽  
Jin Guo ◽  
...  
Keyword(s):  
High Risk ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Risk Area ◽  
High Risk Area

Glutamate carboxypeptidase II gene polymorphisms and neural tube defects in a high-risk Chinese population

2011 ◽  
Vol 27 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Hua Xie ◽  
Jin Guo ◽  
Jianhua Wang ◽  
Fang Wang ◽  
Huizhi Zhao ◽  
...  
Keyword(s):  
High Risk ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Glutamate Carboxypeptidase Ii ◽  
Glutamate Carboxypeptidase

Association betweenPTCH1polymorphisms and risk of neural tube defects in a Chinese population

2013 ◽  
Vol 97 (6) ◽  
pp. 409-415 ◽  
Author(s):  
Zhen Wang ◽  
Li Wang ◽  
Shaofang Shangguan ◽  
Xiaolin Lu ◽  
Shaoyan Chang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population

scholarly journals The GLI2 Missense Variant rs3738880 Significantly Increases the Risk of Neural Tube Defects in the Han Chinese Population

2017 ◽  
Vol 1 (3) ◽  
pp. 127 ◽  
Author(s):  
Xue-Yan Yang ◽  
Shu-Xia Chen ◽  
Hui-Li Li ◽  
Cai-Hua Li ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population ◽  
Missense Variant ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Effect of incorrect gestational dating on Down's syndrome and neural tube risk assessment

2001 ◽  
Vol 38 (3) ◽  
pp. 230-234 ◽  
Author(s):  
S N Millner
Keyword(s):  
High Risk ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Analytical Data ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Low Risk ◽  
Risk Pregnancy ◽  
Median Level ◽  
Risk Patients

Down's syndrome risks are estimated between 15 and 20 completed weeks' gestation (cGW) using an algorithm involving maternal age and serum x-fetoprotein (AFP), chorionic gonadotrophin and unconjugated oestriol levels, each expressed as a multiple of the median level (MoM) at the cGW. The AFP MoM itself is the basis for screening for open neural tube defects (oNTD). Because medians change during this period, gestational dating must be accurate so that appropriate medians are used. A calculated Down's syndrome risk >1:380 at term is generally considered to indicate a 'high-risk' pregnancy. This study focused on 378 patients with reported risk ≤1:500 based on physician-supplied cGW (and hence considered at 'low risk' for Down's syndrome) to determine the effect of common 1-2-week dating errors on risk estimates. Using the original analytical data, each patient's risk was recalculated for each week over the 15-20 weeks, and classified into three categories: <1:380 'low'; 1:380-1:100 'moderate'; and >1:100 'high'. Advancing originally 'low-risk' patients by one week increased the risk by 1·09-14·1 times (median 3·18, mean 3·60); 46 (12·2%) became 'moderate' and 2 (0·5%) became 'high' risk. Advancing by two weeks increased risks 1·58-60·5 times (median 10·03, mean 12·04); 131 (36·5%) became 'moderate' and 39 (10.9%) became 'high' risk. Predictably, oNTD screening results also were affected. Although 1-2 week differences in AFP medians had little effect on most patients in this study sample, some who originally were oNTD negative became oNTD positive, whereas others who had been oNTD positive became screen negative. Thus, in many cases, a 1-2 week dating error may have only minimal effect on the estimated risks for chromosome or neural tube defects, but in other cases the effect of such an error would be significant.

scholarly journals Levels of PAH–DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population

2015 ◽  
Vol 46 ◽  
pp. 73-78 ◽  
Author(s):  
Deqing Yi ◽  
Yue Yuan ◽  
Lei Jin ◽  
Guodong Zhou ◽  
Huiping Zhu ◽  
...  
Keyword(s):  
Cord Blood ◽  
Dna Adducts ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population
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