Stem Cell Therapy for Chronic Myocardial Infarction

Purpose: Adult stem cells are among the new methods of approaching the treatment of myocardial tissue damage. The purpose of this review is to clarify misconceptions about stem cell therapy efficacy in clinical trials and provide a thorough understanding of adult stem cells as a future treatment for patients with myocardial infarction. Methods: A comprehensive review of literature was performed analyzing and comparing 12 clinical trials involving the treatment of patients with acute and chronic myocardial infarction. Results: Stem cell treatments carry an excellent safety profile with the ease of one-time dosing, and have shown dramatic functional improvements while reducing the recurrence of myocardial infarction and enhancing quality of life. Important changes with adult stem cell treatments include 1) formation of new cardiomyocytes, 2) sufficient and sustained improvements in cardiac output, 3) increased myocardial contractility, 4) decreased infarct zone diameter, 5) increased left ventricular function, 6) increased exercise ability, and 7) increased coronary perfusion secondary to neovascularization. Conclusion: At this time, based on the current clinical evidence, adult stem cell therapy is in a position to be considered as an optional treatment for patients with acute or chronic myocardial infarction. Adult stem cell therapy is still in experimental stages of development and the continued clinical involvement will provide more evidence to the therapeutic effects of the treatment.

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Stem cell therapy in acute myocardial infarction: a review of clinical trials

Translational Research ◽

10.1016/j.trsl.2009.06.009 ◽

2010 ◽

Vol 155 (1) ◽

pp. 10-19 ◽

Cited By ~ 52

Author(s):

Jon C. George

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Clinical Trials ◽

Stem Cell ◽

Cell Therapy ◽

Stem Cell Therapy

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ST-elevation myocardial infarction complicated by cardiac arrest in a young patient with familiar dyslipidemia

Tạp chí Nghiên cứu Y học ◽

10.52852/tcncyh.v148i12.789 ◽

2021 ◽

Vol 148 (12) ◽

pp. 141-145

Author(s):

Pham Minh Tuan ◽

Doan Tuan Vu

Keyword(s):

Myocardial Infarction ◽

Cardiac Arrest ◽

Stem Cell ◽

Cell Therapy ◽

Young Patient ◽

Stem Cell Therapy ◽

St Elevation Myocardial Infarction ◽

Lipid Lowering ◽

Lipid Lowering Therapy ◽

St Elevation

Coronary heart disease in young patients always poses great challenges for every healthcare system with differences in clinical manifestations, etiology, epidemiology, angiographic characteristics and prognosis. The objective of this study was to describe a case of ST-elevation myocardial infarction complicated by cardiac arrest in a young patient with familial dyslipidemia. A 30-year-old male visited our hospital with typical angina. During the examination, he suﬀered a sudden loss of consciousness, the monitor showed ventricular fibrillation. After successful resuscitation of cardiac arrest, electrocardiography showed apparent ST-elevation from V2 to V6 leads consistent with the diagnosis of anterolateral infarction. Emergency coronary angiogram showed severe three-vessel lesions including complete occlusion of the LAD artery and 80 - 90% stenosis of the other two coronary branches. Our patient’s coronary arteries were revascularized using drug-eluting stents in LAD artery and subsequently RCA artery, stem cell therapy was applied during the interventional process. Routine laboratory test results showed dyslipidemia and his family records suggested familiar (hereditary) dyslipidemia which affected his mother and sister. 1-month follow-up echocardiography showed a drastic improvement of LVEF by roughly 15%. The combination of revascularization, stem cell therapy, and lipid-lowering therapy has shown a good therapeutic effect.

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