scholarly journals A Review of Human Pluripotent Stem Cell-Derived Cardiomyocytes for High-Throughput Drug Discovery, Cardiotoxicity Screening, and Publication Standards

2012 ◽  
Vol 6 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Nicholas M. Mordwinkin ◽  
Paul W. Burridge ◽  
Joseph C. Wu
Keyword(s):  
Stem Cell ◽  
Drug Discovery ◽  
High Throughput ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Publication Standards

scholarly journals Human pluripotent stem cell-derived cardiomyocyte based models for cardiotoxicity and drug discovery

2016 ◽  
Vol 15 (11) ◽  
pp. 1455-1458 ◽  
Author(s):  
Yimu Zhao ◽  
Anastasia Korolj ◽  
Nicole Feric ◽  
Milica Radisic
Keyword(s):  
Stem Cell ◽  
Drug Discovery ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell

scholarly journals Human Pluripotent Stem Cell Applications in Drug Discovery and Toxicology – An overview

10.5772/58485 ◽  
2014 ◽  
Author(s):  
Shiva Prasad Potta ◽  
Tomo Šarić ◽  
Michael Heke ◽  
Harinath Bahudhanapati ◽  
Jürgen Hescheler
Keyword(s):  
Stem Cell ◽  
Drug Discovery ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell

scholarly journals Human Pluripotent Stem Cell-Derived Cardiac Cells: Application in Disease Modeling, Cell Therapy, and Drug Discovery

2021 ◽  
Vol 9 ◽  
Author(s):  
Juan Huang ◽  
Qi Feng ◽  
Li Wang ◽  
Bingying Zhou
Keyword(s):  
Stem Cell ◽  
Drug Discovery ◽  
Cell Therapy ◽  
Pluripotent Stem Cell ◽  
Disease Modeling ◽  
Three Dimensional ◽  
Cardiac Cells ◽  
Cardiac Diseases ◽  
Human Pluripotent Stem Cell ◽  
Species Specific

Cardiac diseases are the leading cause of deaths worldwide; however, to date, there has been limited progress in the development of therapeutic options for these conditions. Animal models have been the most extensively studied methods to recapitulate a wide variety of cardiac diseases, but these models exhibit species-specific differences in physiology, metabolism and genetics, which lead to inaccurate and unpredictable drug safety and efficacy results, resulting in drug attrition. The development of human pluripotent stem cell (hPSC) technology in theory guarantees an unlimited source of human cardiac cells. These hPSC-derived cells are not only well suited for traditional two-dimensional (2-D) monoculture, but also applicable to more complex systems, such as three-dimensional (3-D) organoids, tissue engineering and heart on-a-chip. In this review, we discuss the application of hPSCs in heart disease modeling, cell therapy, and next-generation drug discovery. While the hPSC-related technologies still require optimization, their advances hold promise for revolutionizing cell-based therapies and drug discovery.

scholarly journals Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome

EBioMedicine ◽  
2016 ◽  
Vol 9 ◽  
pp. 293-305 ◽  
Author(s):  
Hélène Darville ◽  
Aurélie Poulet ◽  
Frédérique Rodet-Amsellem ◽  
Laure Chatrousse ◽  
Julie Pernelle ◽  
...  
Keyword(s):  
Stem Cell ◽  
High Throughput ◽  
Cortical Neurons ◽  
Pluripotent Stem Cell ◽  
Proof Of Concept ◽  
Human Pluripotent Stem Cell ◽  
Concept Study ◽  
Medication Screening

High-Throughput Discovery of Targeted, Minimally Complex Peptide Surfaces for Human Pluripotent Stem Cell Culture

2021 ◽  
Author(s):  
Anusuya Ramasubramanian ◽  
Riya Muckom ◽  
Caroline Sugnaux ◽  
Christina Fuentes ◽  
Barbara L. Ekerdt ◽  
...  
Keyword(s):  
Cell Culture ◽  
Stem Cell ◽  
High Throughput ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Stem Cell Culture

scholarly journals High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias

2013 ◽  
Vol 10 (12) ◽  
pp. 1225-1231 ◽  
Author(s):  
Emanuel J P Nazareth ◽  
Joel E E Ostblom ◽  
Petra B Lücker ◽  
Shreya Shukla ◽  
Manuel M Alvarez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
High Throughput ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Stem Cell Fate
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