Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat

2008 ◽  
Vol 31 (9) ◽  
pp. 1160-1165 ◽  
Author(s):  
Hee Seung Lee ◽  
Kyung-Hee Jung ◽  
Sang-Won Hong ◽  
In-Suh Park ◽  
Chongmu Lee ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Acute Liver Damage

Protective and Therapeutic Effects of Curcuma xanthorrhiza on Hepatotoxin-induced Liver Damage

1995 ◽  
Vol 23 (03n04) ◽  
pp. 243-254 ◽  
Author(s):  
Song-Chow Li ◽  
Chun-Ching Lin ◽  
Yun-Ho Lin ◽  
S. Supriyatna ◽  
Chao-Wei Teng
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Intraperitoneal Administration ◽  
Therapeutic Effects ◽  
Acute Liver Damage ◽  
Liver Injuries ◽  
Acute Elevation ◽  
Serum Transaminases ◽  
Hepatoprotective Agent ◽  
Curcuma Xanthorrhiza

Curcuma xanthorrhiza Roxb. (Zingiberaceae family, commonly known as temu lawak or Javanese turmeric in Indonesia), which is found both wild and cultivated in Indonesia, has been traditionally used for medicinal purposes. C. xanthorrhiza is also used as a tonic in Indonesia. The aim of the present study is to clarify whether C. xanthorrhiza treatment may prevent acute liver damage induced by acetaminophen and carbon tetrachloride in mice. The results clearly indicated that extract of C. xanthorrhiza could reduce significantly the acute elevation of serum transaminases levels induced by the two kinds of hepatotoxins, and alleviated the degree of liver damage at 24 hours after the intraperitoneal administration of two hepatotoxins. It may be concluded that C. xanthorrhiza can protect the liver from various hepatotoxins, hence C. xanthorrhiza could be useful in the treatment of liver injuries and has promise as a kind of broad spectrum hepatoprotective agent.

Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse

2013 ◽  
Vol 35 (3) ◽  
pp. 517-523 ◽  
Author(s):  
Min-Cheol Kang ◽  
Sung-Myung Kang ◽  
Ginnae Ahn ◽  
Kil-Nam Kim ◽  
Nalae Kang ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Liver Damage ◽  
Acute Liver Damage

Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats

2007 ◽  
Vol 112 (1) ◽  
pp. 145-151 ◽  
Author(s):  
Didem Deliorman Orhan ◽  
Nilüfer Orhan ◽  
Ender Ergun ◽  
Fatma Ergun
Keyword(s):  
Carbon Tetrachloride ◽  
Vitis Vinifera ◽  
Liver Damage ◽  
Hepatoprotective Effect ◽  
Vitis Vinifera L ◽  
Acute Liver Damage

Protective effect of colchicine on acute liver damage induced by carbon tetrachloride

1988 ◽  
Vol 6 (3) ◽  
pp. 337-342 ◽  
Author(s):  
Marisabel Mourelle ◽  
C. Villalon ◽  
J.L. Amezcua
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Liver Damage ◽  
Acute Liver Damage

scholarly journals Hepatoprotective Activity of the Total Saponins fromActinidia valvataDunn Root against Carbon Tetrachloride-Induced Liver Damage in Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Liping Qu ◽  
Hailiang Xin ◽  
Guoyin Zheng ◽  
Yonghua Su ◽  
Changquan Ling
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Caspase 3 ◽  
Hepatoprotective Activity ◽  
Serum Marker ◽  
Acute Liver Damage ◽  
Inflammatory Infiltration ◽  
Liver Histopathology ◽  
Protein Expressions

The protective activity of the total saponins fromActinidia valvataDunn root (TSAV) was studied against carbon-tetrachloride- (CCl4-) induced acute liver injury in mice. Mice were orally administered TSAV (50, 100, and 200 mg/kg) for five days and then given CCl4. TSAV pretreatment significantly prevented the CCl4-induced hepatic damage as indicated by the serum marker enzymes (AST, ALT, and ALP). Parallel to these changes, TSAV also prevented CCl4-induced oxidative stress by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzymes (SOD, CAT, GR, and GPX), GSH and GSSG. In addition, TSAV attenuated the serum TNF-αand IL-6 levels and inhibited the serum iNOS and NO levels. Liver histopathology indicated that TSAV alleviated CCl4-induced inflammatory infiltration and focal necrosis. TSAV (200 mg/kg) also significantly decreased Bak, Bax mRNA and Fas, FasL, p53, and NF-κB p65 protein expressions and increased Bcl-2 mRNA and protein expressions. Meanwhile, TSAV significantly downregulated caspase-3 and caspase-8 activities and prevented CCl4-induced hepatic cell apoptosis. In addition, TSAV exhibited antioxidant activity through scavenging hydroxyl and DPPH free radicalsin vitro. These results indicated that TSAV could protect mice against CCl4-induced acute liver damage possibly through antioxidant, anti-inflammatory activities and regulating apoptotic-related genes.

Effect of Policosanol on Carbon Tetrachloride-Induced Acute Liver Damage in Sprague-Dawley Rats

Drugs in R&D ◽  
2003 ◽  
Vol 4 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Miriam Noa ◽  
Sarah?? Mendoza ◽  
Rosa M??s ◽  
Nilda Mendoza
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Sprague Dawley ◽  
Acute Liver Damage ◽  
Sprague Dawley Rats

Stellate cell specific overexpression of IGF-I reduces acute liver damage induced by carbon-tetrachloride in vivo

2000 ◽  
Vol 118 (4) ◽  
pp. A1013
Author(s):  
Song Ling Liu ◽  
Sonia Sanz ◽  
Jolanta B. Pucilowska ◽  
C. Randall Fuller ◽  
Jesus Prieto ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Stellate Cell ◽  
Acute Liver Damage ◽  
Igf I
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