Plasma amino acid levels after carbon tetrachloride induced acute liver damage. A dose-response and time-response study in rats

Curcuma xanthorrhiza Roxb. (Zingiberaceae family, commonly known as temu lawak or Javanese turmeric in Indonesia), which is found both wild and cultivated in Indonesia, has been traditionally used for medicinal purposes. C. xanthorrhiza is also used as a tonic in Indonesia. The aim of the present study is to clarify whether C. xanthorrhiza treatment may prevent acute liver damage induced by acetaminophen and carbon tetrachloride in mice. The results clearly indicated that extract of C. xanthorrhiza could reduce significantly the acute elevation of serum transaminases levels induced by the two kinds of hepatotoxins, and alleviated the degree of liver damage at 24 hours after the intraperitoneal administration of two hepatotoxins. It may be concluded that C. xanthorrhiza can protect the liver from various hepatotoxins, hence C. xanthorrhiza could be useful in the treatment of liver injuries and has promise as a kind of broad spectrum hepatoprotective agent.

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Effect of the New Rhone-Poulenc Polyacrilonitrile Membrane on Plasma Amino Acid Levels and Depth of Coma in Fulminant Hepatic Failure

Clinical Science ◽

10.1042/cs051014p ◽

1976 ◽

Vol 51 (3) ◽

pp. 14P-14P

Author(s):

D. B. A. Silk ◽

R. A. Chase ◽

P. N. Trewby ◽

M. J. Weston ◽

P. Wheeler ◽

...

Keyword(s):

Amino Acid ◽

Fulminant Hepatic Failure ◽

Hepatic Failure ◽

Plasma Amino Acid ◽

Amino Acid Levels

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The Effects of Test Doses of Leucine, Isoleucine or Valine on Plasma Amino Acid Levels

American Journal of Clinical Nutrition ◽

10.1093/ajcn/17.5.317 ◽

1965 ◽

Vol 17 (5) ◽

pp. 317-321 ◽

Cited By ~ 35

Author(s):

MARIAN E. SWENDSEID ◽

JUANITA VILLALOBOS ◽

WILLIAM S. FIGUEROA ◽

ERNST J. DRENICK

Keyword(s):

Amino Acid ◽

Plasma Amino Acid ◽

Amino Acid Levels

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P079 CHANGES IN PLASMA AMINO ACID LEVELS: A MINIMALLY INVASIVE INNOVATIVE WAY TO DIAGNOSE INTESTINAL REJECTION IN PIGS

Clinical Nutrition Supplements ◽

10.1016/s1744-1161(09)70129-2 ◽

2009 ◽

Vol 4 (2) ◽

pp. 58

Author(s):

T. Yandza ◽

N. Neveux ◽

M. Saint-Paul ◽

F. Berthier ◽

J. Gugenheim ◽

...

Keyword(s):

Amino Acid ◽

Minimally Invasive ◽

Plasma Amino Acid ◽

Amino Acid Levels

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BLOOD AMINO ACID STUDIES: IV. SOME FACTORS AFFECTING PLASMA AMINO ACID LEVELS IN HUMAN SUBJECTS

Canadian Journal of Biochemistry and Physiology ◽

10.1139/y63-024 ◽

1963 ◽

Vol 41 (1) ◽

pp. 191-199 ◽

Cited By ~ 3

Author(s):

J. M. McLaughlan ◽

F. J. Noel ◽

A. B. Morrison ◽

J. A. Campbell

Keyword(s):

Amino Acid ◽

Human Subjects ◽

Plasma Amino Acid ◽

Small Samples ◽

Breakfast Cereal ◽

Specific Amino Acid ◽

Factors Affecting ◽

Practical Procedure ◽

Plasma Amino Acid Response ◽

Amino Acid Levels

Free lysine, methionine, threonine, and tryptophan were determined in small samples of blood obtained by finger punch from human subjects. The levels of the four amino acids rose rapidly after the subjects consumed protein as baked halibut; the extent and duration of the increases were roughly proportional to the amount of protein eaten and to the amino acid composition of the protein. The increases of free methionine and threonine in plasma were somewhat less when butter was taken with fish but starch (as potato) or sucrose did not affect the values. Other foods tested at the 19.0-g level of protein included egg, a commercial breakfast cereal, and the same cereal plus milk. In general the increase or decrease of each amino acid tested was related to the amount of that amino acid in the test food. The plasma amino acid (PAA) ratio of Longenecker and Hause was calculated for each food and was useful in evaluating the increase or decrease of each specific amino acid. The present work appears to offer a practical procedure for studying the plasma amino acid response of groups of human subjects to variations in dietary protein.

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