Co-delivery of mitochondrial targeted lonidamine and PIN1 inhibitor ATRA by nanoparticulate systems for synergistic metastasis suppression

Cancer, an uncontrollable growth of cells, is among the leading causes of mortality and morbidity throughout the world. Malignant neoplasms are difficult to treat diseases because of their single in kind characteristics such as tissue invasion, metastasis, evading reticuloendothelial system (RES) and so forth. In recent decade polymeric nanoparticulate systems has gained special attention in drug delivery and targeting among all biocompatible nanoforms. Among these systems, chitosan-based hydrogel nanoparticles have been wildly utilized for drug delivery purposes. The usage of chitosan nanogels in cancer therapy significantly improved in recent years. The various cancers were the target of chitosan nanogels. Also, modification of other delivery systems with chitosan were much reported. The aim of this study is the review and update of the recent studies on chitosan nanogels applications in cancer therapy by focus on cancer based classification.

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Faculty Opinions recommendation of ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718362415.793522748 ◽

2016 ◽

Author(s):

Robert Coffey ◽

Bhuminder Singh

Keyword(s):

Lung Adenocarcinoma ◽

Metastasis Suppression

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Molecular Mechanisms of Metastasis Suppression in Human Breast Cancer.

10.21236/ada371153 ◽

1999 ◽

Author(s):

Danny R. Welch

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Molecular Mechanisms ◽

Human Breast ◽

Metastasis Suppression

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Mechanism of Tumor Metastasis Suppression by the KA11 Gene

10.21236/ada467606 ◽

2007 ◽

Author(s):

Kounosuke Watabe

Keyword(s):

Tumor Metastasis ◽

Metastasis Suppression

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Inorganic Gold and Polymeric Poly(Lactide-co-glycolide) Nanoparticles as Novel Strategies to Ameliorate the Biological Properties of Antimicrobial Peptides

Current Protein and Peptide Science ◽

10.2174/1389203720666191203101947 ◽

2020 ◽

Vol 21 (4) ◽

pp. 429-438 ◽

Cited By ~ 1

Author(s):

Bruno Casciaro ◽

Francesca Ghirga ◽

Deborah Quaglio ◽

Maria Luisa Mangoni

Keyword(s):

Antimicrobial Peptides ◽

Biological Properties ◽

Biological Profile ◽

Innovative Strategy ◽

Different Types ◽

New Antibiotics ◽

Interesting Class ◽

Alternative Antimicrobials ◽

Nanoparticulate Systems ◽

Infective Activity

Cationic antimicrobial peptides (AMPs) are an interesting class of gene-encoded molecules endowed with a broad-spectrum of anti-infective activity and immunomodulatory properties. They represent promising candidates for the development of new antibiotics, mainly due to their membraneperturbing mechanism of action that very rarely induces microbial resistance. However, bringing AMPs into the clinical field is hampered by some intrinsic limitations, encompassing low peptide bioavailability at the target site and high peptide susceptibility to proteolytic degradation. In this regard, nanotechnologies represent an innovative strategy to circumvent these issues. According to the literature, a large variety of nanoparticulate systems have been employed for drug-delivery, bioimaging, biosensors or nanoantibiotics. The possibility of conjugating different types of molecules, including AMPs, to these systems, allows the production of nanoformulations able to enhance the biological profile of the compound while reducing its cytotoxicity and prolonging its residence time. In this minireview, inorganic gold nanoparticles (NPs) and biodegradable polymeric NPs made of poly(lactide-coglycolide) are described with particular emphasis on examples of the conjugation of AMPs to them, to highlight the great potential of such nanoformulations as alternative antimicrobials.

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