Mechanism of Tumor Metastasis Suppression by the KA11 Gene

2007 ◽  
Author(s):  
Kounosuke Watabe
Keyword(s):  
Tumor Metastasis ◽  
Metastasis Suppression

Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis

Blood ◽  
2008 ◽  
Vol 112 (5) ◽  
pp. 1730-1739 ◽  
Author(s):  
Youya Nakazawa ◽  
Shigeo Sato ◽  
Mikihiko Naito ◽  
Yukinari Kato ◽  
Kazuhiko Mishima ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Tumor Metastasis ◽  
Ectopic Expression ◽  
Metastasis Suppressor ◽  
Low Density ◽  
Hematogenous Spread ◽  
Lung Retention ◽  
Ht1080 Cells ◽  
Metastasis Suppression ◽  
The Relationship

Abstract CD9 has been reported to play a role in tumor metastasis suppression. However, it is not fully understood how CD9 affects the hematogenous spread of tumor cells. To clarify a new mechanism (or mechanisms), we generated HT1080 cells that had been transfected with a CD9-expressing plasmid. Ectopic expression of CD9 in HT1080 cells actually reduced their metastatic ability. CD9 expression reduced lung retention and platelet ag-gregation activity of the transfectants. Because HT1080 cells express the metastasis-promoting, platelet aggregation-inducing factor Aggrus/podoplanin on their surface, we examined the relationship between CD9 and Aggrus. We discovered that CD9 formed a complex with Aggrus via transmembrane domains 1 and 2 (TM1 and TM2) of CD9. Investigation of the interaction revealed that each CD9 and Aggrus interacted homophilically, and that they colocalized in low-density membrane fractions. Deleting TM1 and TM2 attenuated the ability of CD9 to interact homophilically or to localize in low-density membrane fractions. The expression of CD9–wild-type (WT), but not CD9 lacking TM1 and TM2, attenuated the platelet aggregation and metastasis induced by forced expression of Aggrus in CHO cells. Therefore, CD9 may act as a metastasis suppressor, at least in part, by neutralizing Aggrus-mediated platelet aggregation.

Metformin and Docosahexaenoic Acid Hybrid Micelles for Premetastatic Niche Modulation and Tumor Metastasis Suppression

Nano Letters ◽  
2019 ◽  
Vol 19 (6) ◽  
pp. 3548-3562 ◽  
Author(s):  
Tianze Jiang ◽  
Liang Chen ◽  
Yukun Huang ◽  
Jiahao Wang ◽  
Minjun Xu ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Tumor Metastasis ◽  
Premetastatic Niche ◽  
Metastasis Suppression

A dual-catalytic nanoreactor for synergistic chemodynamic-starvation therapy toward tumor metastasis suppression

2021 ◽  
Author(s):  
Huiwen Zhang ◽  
Fei Lu ◽  
Wei Pan ◽  
Yegang Ge ◽  
Bingjie Cui ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Tumor Metastasis ◽  
Metastatic Tumors ◽  
Metastasis Suppression ◽  
Effective Treatments

Tumor metastasis is extremely deadly for cancer patients and developing effective treatments for deep metastatic tumors remains a major challenge. In this study, we demonstrated a dual-catalytic nanoreactor for tumor...

Sequentially Triggered Bacterial Outer Membrane Vesicles for Macrophage Metabolism Modulation and Tumor Metastasis Suppression

ACS Nano ◽  
2021 ◽  
Author(s):  
Qin Guo ◽  
Xuwen Li ◽  
Wenxi Zhou ◽  
Yongchao Chu ◽  
Qinjun Chen ◽  
...  
Keyword(s):  
Outer Membrane ◽  
Tumor Metastasis ◽  
Membrane Vesicles ◽  
Outer Membrane Vesicles ◽  
Metastasis Suppression ◽  
Bacterial Outer Membrane

scholarly journals Rational design of non-toxic GOx-based biocatalytic nanoreactor for multimodal synergistic therapy and tumor metastasis suppression

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10001-10011
Author(s):  
Lifeng Hang ◽  
Tao Zhang ◽  
Hua Wen ◽  
Meng Li ◽  
Lianbao Liang ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Rational Design ◽  
Metastasis Suppression
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