scholarly journals Outcome of Acute Myeloid Leukemia in Children Adolescents and Young Adults Treated with an Uniform Protocol in Casablanca, Morocco

2018 ◽  
Vol 35 (2) ◽  
pp. 255-259
Author(s):  
B. Housou ◽  
S. Cherkaoui ◽  
M. Lamchahab ◽  
R. Massi ◽  
N. Khoubila ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Adults ◽  
Myeloid Leukemia ◽  
Adolescents And Young Adults ◽  
Leukemia In Children ◽  
Acute Myeloid

Adolescents and young adults with acute lymphoblastic leukemia and acute myeloid leukemia

2017 ◽  
Vol 11 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Mirella Ampatzidou ◽  
Charikleia Kelaidi ◽  
Michael N. Dworzak ◽  
Sophia Polychronopoulou
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Adults ◽  
Acute Lymphoblastic Leukemia ◽  
Myeloid Leukemia ◽  
Lymphoblastic Leukemia ◽  
Adolescents And Young Adults ◽  
Acute Myeloid

scholarly journals Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents, and young adults with relapsed acute myeloid leukemia

Cancer ◽  
2020 ◽  
Vol 126 (21) ◽  
pp. 4800-4805
Author(s):  
Seth E. Karol ◽  
Todd M. Cooper ◽  
Paul E. Mead ◽  
Kristine R. Crews ◽  
John C. Panetta ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Adults ◽  
Myeloid Leukemia ◽  
Adolescents And Young Adults ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Relapsed Acute Myeloid Leukemia ◽  
Acute Myeloid

Acute Myeloid Leukemia in Adolescents and Young Adults Treated in Pediatric and Adult Departments in the Nordic Countries

2015 ◽  
Vol 63 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Lovisa Wennström ◽  
Pernille Wendtland Edslev ◽  
Jonas Abrahamsson ◽  
Jan Maxwell Nørgaard ◽  
Yngvar Fløisand ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Adults ◽  
Myeloid Leukemia ◽  
Nordic Countries ◽  
Adolescents And Young Adults ◽  
Acute Myeloid

Effect of the type of treatment facility on the outcome of acute myeloid leukemia in adolescents and young adults

Leukemia ◽  
2015 ◽  
Vol 30 (5) ◽  
pp. 1177-1180 ◽  
Author(s):  
R S Go ◽  
A C Bartley ◽  
A Al-Kali ◽  
N D Shah ◽  
E B Habermann
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Adults ◽  
Myeloid Leukemia ◽  
Adolescents And Young Adults ◽  
Treatment Facility ◽  
Acute Myeloid

scholarly journals Outcome Among Adolescents and Young Adults with Acute Myeloid Leukemia at Pediatric Versus Adult Centers: A Population-Based Study Using the IMPACT Cohort

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4749-4749
Author(s):  
Sumit Gupta ◽  
Nancy Baxter ◽  
Jason Pole ◽  
Cindy Lau ◽  
Rinku Sutradhar ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Adults ◽  
Acute Lymphoblastic Leukemia ◽  
Myeloid Leukemia ◽  
Conflicts Of Interest ◽  
Lymphoblastic Leukemia ◽  
Population Based ◽  
Adolescents And Young Adults ◽  
The Impact ◽  
Acute Myeloid

Background: Survival outcomes among adolescents and young adults (AYA) with acute myeloid leukemia (AML) remain poor. In AYA with acute lymphoblastic leukemia, outcomes differ between patients treated in pediatric vs. adult centers. This has not been well evaluated in AML. We therefore compared outcomes between AYA with AML treated at pediatric vs. adult centers using a population-based clinical database. In addition, we determined other predictors of outcome within this population. Methods: The IMPACT Cohort comprises all Ontario, Canada AYA aged 15-21 years diagnosed with one of six common cancers (including AML) between 1992-2012. Detailed demographic, disease, treatment, and outcome data were collected through chart abstraction and validated by content experts. Locus of cancer care (LOC - pediatric vs. adult center) was determined based on where the majority of therapy was delivered in the first three months after diagnosis. Linkage to population-based health administrative data identified additional cancer events (second cancers, relapse, death). Event-free (EFS) and overall survival (OS) were determined using Kaplan-Meier methods. The impact of LOC on EFS and OS was determined using multivariable Cox proportional hazard models, adjusting for demographic, disease, and treatment variables. Events included disease progression, relapse, death, and second malignancies. Results: Among 140 AYA with AML, 89 (63.6%) received therapy at an adult center. AYA treated in pediatric centers were younger than those treated at adult centers (median 16 years vs. 19 years; p<0.001) and were more likely to live in higher-income neighborhoods [37/51 (72.5%) vs. 47/89 (52.8%); p=0.02]. Disease markers such as presenting white blood cell count and AML subtype did not differ by LOC. The 5-year EFS and OS for the whole cohort were 35.0%±4.0% and 53.6%±4.2%. Neither EFS nor OS differed by LOC (Table 1). In multivariable analyses adjusting for disease characteristics, LOC was not predictive of either EFS [adult vs. pediatric center hazard ratio (HR) 1.3, 95thconfidence interval (CI) 0.8-2.2, p=0.27] or OS (HR 1.0, CI 0.6-1.6, p=0.97). AYA with AML living in rural areas however experienced significantly inferior outcomes as compared to their urban counterparts (EFS: HR 2.5, CI 1.3-4.7, p=0.005; OS: HR 2.0, CI 1.1-3.8, p=0.04). Conclusions: In this population-based cohort, outcomes did not differ between AYA with AML treated at pediatric vs. adult centers, unlike what has been previously shown in AYA with acute lymphoblastic leukemia. However, rural AYA experienced substantially inferior outcomes than urban AYA, suggesting that even within a universal single payer system of healthcare, socioeconomic disparities persist in this population. Disclosures No relevant conflicts of interest to declare.

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