Myeloid Neoplasm with t(8;22)(p11;q11): A Mimicker of Chronic Myeloid Leukaemia in Blast Crisis

2020 ◽  
Author(s):  
Gargi Kapatia ◽  
Arun Sasikumar Nair Remani ◽  
Shano Naseem ◽  
Mayur Parihar ◽  
Sreejesh Sreedharanunni
Keyword(s):  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Blast Crisis ◽  
Myeloid Neoplasm

scholarly journals Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yotaro Ochi ◽  
Kenichi Yoshida ◽  
Ying-Jung Huang ◽  
Ming-Chung Kuo ◽  
Yasuhito Nannya ◽  
...  
Keyword(s):  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Kinase Inhibitors ◽  
Blast Crisis ◽  
Clonal Evolution ◽  
Chronic Phase ◽  
Genetic Alterations ◽  
Prognostic Impact ◽  
Genetic Abnormalities ◽  
Prior Use

AbstractBlast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role in BC, the landscape and prognostic impact of these alterations remain elusive. Here, we comprehensively investigate genetic abnormalities in 136 BC and 148 chronic phase (CP) samples obtained from 216 CML patients using exome and targeted sequencing. One or more genetic abnormalities are found in 126 (92.6%) out of the 136 BC patients, including the RUNX1-ETS2 fusion and NBEAL2 mutations. The number of genetic alterations increase during the transition from CP to BC, which is markedly suppressed by tyrosine kinase inhibitors (TKIs). The lineage of the BC and prior use of TKIs correlate with distinct molecular profiles. Notably, genetic alterations, rather than clinical variables, contribute to a better prediction of BC prognosis. In conclusion, genetic abnormalities can help predict clinical outcomes and can guide clinical decisions in CML.

An atypical isolated CNS blast crisis in chronic myeloid leukaemia

2018 ◽  
Vol 79 (8) ◽  
pp. 470-471
Author(s):  
Mesut Sivri ◽  
Yahya Paksoy ◽  
Mehmet Dağlı ◽  
Kazım Serhan Keles˛oğlu ◽  
Mustafa Koplay
Keyword(s):  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Blast Crisis

scholarly journals Central nervous system blast crisis of chronic myeloid leukaemia misdiagnosed as tubercular meningitis

2018 ◽  
pp. bcr-2017-223923 ◽  
Author(s):  
Banshi Lal Kumawat ◽  
Chandra Mohan Sharma ◽  
Pankaj Kumar Saini ◽  
Ankur Garg
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Blast Crisis ◽  
Tubercular Meningitis

scholarly journals Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate

2003 ◽  
Vol 122 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Aikaterini Barbouti ◽  
Tomas Ahlgren ◽  
Bertil Johansson ◽  
Mattias Höglund ◽  
Carin Lassen ◽  
...  
Keyword(s):  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Imatinib Mesylate ◽  
Blast Crisis ◽  
Genetic Studies

Early T-cell features in blast crisis of Ph1-positive chronic myeloid leukaemia

2009 ◽  
Vol 35 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Francisco Cervantes ◽  
Ignacio Anegon ◽  
Ciril Rozman ◽  
Teresa Gallart ◽  
Arturo Pereira ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Blast Crisis

scholarly journals Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia

2006 ◽  
Vol 133 (4) ◽  
pp. 400-402 ◽  
Author(s):  
Thomas Pabst ◽  
Erica Stillner ◽  
Donna Neuberg ◽  
Stephen Nimer ◽  
Cheryl L. Willman ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Blast Crisis
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