scholarly journals Urinary Organic Acids Quantitated in a Healthy North Indian Pediatric Population

2014 ◽  
Vol 30 (2) ◽  
pp. 221-229 ◽  
Author(s):  
Chandrawati Kumari ◽  
Ankur Singh ◽  
Siddharth Ramji ◽  
James D. Shoemaker ◽  
Seema Kapoor
Keyword(s):  
Organic Acids ◽  
Indian Pediatric ◽  
Pediatric Population ◽  
Urinary Organic Acids

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population

1994 ◽  
Vol 40 (6) ◽  
pp. 862-868 ◽  
Author(s):  
F Guneral ◽  
C Bachmann
Keyword(s):  
Organic Acids ◽  
Reference Data ◽  
Pediatric Population ◽  
Age Groups ◽  
Caloric Intake ◽  
Urinary Organic Acids ◽  
Age Related ◽  
Data Correlations ◽  
The Individual ◽  
Urine Specimens

Abstract Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days to 16 years, subdivided into five age groups. We quantified 69 organic acids (32 major and 37 minor components) and report here the median values and percentiles for each compound, adjusted for creatinine content, for the five groups. Concentrations of most of the organic acids tend to decrease with age but display substantial differences between age groups. This emphasizes the importance of comparing patients' data with age-matched reference data. Correlations between the excretion of organic acids and protein or caloric intake were significant for several compounds.

scholarly journals OCT based macular thickness in a normal Indian pediatric population

2018 ◽  
Vol 13 (2) ◽  
pp. 144 ◽  
Author(s):  
Ritika Mullick ◽  
Bharti Nigam ◽  
Pragati Garg ◽  
Lubna Ahmad
Keyword(s):  
Indian Pediatric ◽  
Pediatric Population ◽  
Macular Thickness

scholarly journals GC-MS profiling of urinary organic acids evaluated as a quantitative method

1996 ◽  
Vol 42 (10) ◽  
pp. 1609-1615 ◽  
Author(s):  
P Duez ◽  
A Kumps ◽  
Y Mardens
Keyword(s):  
Organic Acids ◽  
Classical Method ◽  
Internal Standard ◽  
Selected Ion Monitoring ◽  
Practical Procedure ◽  
Urinary Organic Acids ◽  
Relative Standard ◽  
Analytical Response ◽  
Quantitative Results ◽  
Curvilinear Relationships

Abstract We assessed the quantitative performances of a classical method for profiling urinary organic acids: ethyl acetate extraction/oxime-trimethylsilyl derivatization/GC-MS. Twenty-seven acids were quantified on the basis of specific ions in both scan and selected-ion monitoring modes. We found that the tuning of the mass detector severely affects the calibration factors, being critical to achieve quantitative results, and we propose a practical procedure for reproducible tuning. Of seven compounds tested, tropic acid was retained as the internal standard suitable for most of the acids of clinical interest; a second internal standard, 2-ketocaproic acid, was used in quantifying keto-acids. The within-day and total relative standard deviations (CVs), estimated from scan-mode analyses of urine, ranged from 2.6% to 12.7% and from 4.2% to 11.8%, respectively. Curvilinear relationships between analytical response and concentration were observed for most of the acids investigated.

Gas-chromatographic method of analysis for urinary organic acids. II. Description of the procedure, and its application to diagnosis of patients with organic acidurias.

1980 ◽  
Vol 26 (13) ◽  
pp. 1847-1853 ◽  
Author(s):  
K Tanaka ◽  
A West-Dull ◽  
D G Hine ◽  
T B Lynn ◽  
T Lowe
Keyword(s):  
Organic Acids ◽  
Chromatographic Method ◽  
Normal Subjects ◽  
Retention Indices ◽  
Organic Aciduria ◽  
Organic Acidurias ◽  
Urinary Organic Acids ◽  
Urinary Organic Acid Analysis ◽  
Gas Chromatographic Method ◽  
Extensive List

Abstract A gas-chromatographic method for urinary organic acid analysis is described, designed to be used routinely for the diagnosis of organic aciduria. It involves extraction of urine with ethyl acetate, dehydration of extract residues, and trimethylsilylation. Organic acids are identified by using an extensive list of retention indices published in the accompanying paper (this issue). Quantitative values are given for organic acids in urines from 50 ostensibly normal subjects. Typical chromatograms of urinary organic acids from patients with eight well-established organic acidurias are also shown.

Metabolic profiles of urinary organic acids recovered from absorbent filter paper.

1987 ◽  
Vol 33 (4) ◽  
pp. 572-576 ◽  
Author(s):  
B A Chamberlin ◽  
C C Sweeley
Keyword(s):  
Young Children ◽  
Organic Acids ◽  
Filter Paper ◽  
Metabolic Profiles ◽  
Sample Storage ◽  
Organic Acidurias ◽  
Urinary Organic Acids ◽  
Specimen Collection ◽  
Normal Urine

Abstract We evaluated for reliability and reproducibility a semiquantitative gas-chromatographic assay of organic acids in samples of normal urine recovered from absorbent filter paper. We also evaluated this method for use in diagnosis of some of the more common organic acidurias. Transfer of urine from diapers to absorbent filter paper eases the usual trauma of specimen collection from young children; it also simplifies sample storage and shipment.

Recommendations for urinary organic acids analysis

2020 ◽  
Vol 78 (5) ◽  
pp. 547-554
Author(s):  
Laetitia Van Noolen ◽  
Cécile Acquaviva-Bourdain ◽  
Anne-Frédérique Dessein ◽  
Régine Minet-Quinard ◽  
Marie Nowoczyn ◽  
...  
Keyword(s):  
Organic Acids ◽  
Urinary Organic Acids
Sign in / Sign up

Export Citation Format

Share Document