scholarly journals Monotonic Dose Effect of Bisphenol-A, an Estrogenic Endocrine Disruptor, on Estrogen Synthesis in Female Sprague-Dawley Rats

2017 ◽  
Vol 33 (4) ◽  
pp. 387-396 ◽  
Author(s):  
Subbaiyan Thilagavathi ◽  
Pachaiappan Pugalendhi ◽  
Thangarasu Rajakumar ◽  
Krishnamoorthy Vasudevan
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruptor ◽  
Dose Effect ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Estrogen Synthesis

Acute Toxicity of Administered Bisphenol A Di Glycidyl Ether in Male Sprague Dawley Rats

2006 ◽  
Vol 18 (4) ◽  
pp. 318 ◽  
Author(s):  
Jae un Im ◽  
Yun jung Yang ◽  
Tae jin Lee ◽  
Yeon pyo Hong
Keyword(s):  
Acute Toxicity ◽  
Bisphenol A ◽  
Glycidyl Ether ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Tissue-specific Distribution of Genistein, Daidzein and Bisphenol A in Male Sprague-Dawley Rats after Intragastric Administration

2005 ◽  
Vol 11 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Shin YASUDA ◽  
Po-Sheng WU ◽  
Masaaki OKABE ◽  
Hirofumi TACHIBANA ◽  
Koji YAMADA
Keyword(s):  
Bisphenol A ◽  
Intragastric Administration ◽  
Sprague Dawley ◽  
Tissue Specific ◽  
Specific Distribution ◽  
Sprague Dawley Rats

scholarly journals Anti-infertility significance of aqueous extract of I pomoea batatas (L.) Lam. against exposure of bisphenol A (BPA) promoted testicular toxicity in male Sprague Dawley rats

2013 ◽  
Vol 2 (4) ◽  
pp. 263-271
Author(s):  
Rajendran Revathy ◽  
Kulanthaivel Langeswaran ◽  
Subbaraj Gowtham kumar ◽  
Shanmugam Vijayaprakash ◽  
Peranandam Tamilselvan ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Aqueous Extract ◽  
Testicular Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

MATERNAL-FETAL DISPOSITION OF BISPHENOL A IN PREGNANT SPRAGUE-DAWLEY RATS

2002 ◽  
Vol 65 (5-6) ◽  
pp. 395-406 ◽  
Author(s):  
Beom Soo Shin ◽  
Sun Dong Yoo ◽  
Chang Youn Cho ◽  
Ji Hoon Jung ◽  
Byung Mu Lee ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Lactational transfer of bisphenol A in Sprague–Dawley rats

2010 ◽  
Vol 199 (3) ◽  
pp. 372-376 ◽  
Author(s):  
Daniel R. Doerge ◽  
Michelle Vanlandingham ◽  
Nathan C. Twaddle ◽  
K. Barry Delclos
Keyword(s):  
Bisphenol A ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Lactational Transfer

Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats

2011 ◽  
Vol 255 (3) ◽  
pp. 261-270 ◽  
Author(s):  
Daniel R. Doerge ◽  
Nathan C. Twaddle ◽  
Michelle Vanlandingham ◽  
Ronald P. Brown ◽  
Jeffrey W. Fisher
Keyword(s):  
Bisphenol A ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone

2019 ◽  
Author(s):  
Kathryn L. Schwienteck ◽  
Steven Blake ◽  
Paul T. Bremer ◽  
Justin L. Poklis ◽  
E. Andrew Townsend ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Vaccine Effectiveness ◽  
Dose Effect ◽  
Sprague Dawley ◽  
Vaccine Research ◽  
Opioid Dose ◽  
Sprague Dawley Rats ◽  
Before And After ◽  
Naltrexone Treatment ◽  
Empirical Framework

AbstractBackgroundOne emerging strategy to address the opioid crisis includes opioid-targeted immunopharmacotherapies. This study compared effectiveness of a heroin-tetanus toxoid (TT) conjugate vaccine to antagonize heroin, 6-acetylmorphine (6-AM), morphine, and fentanyl antinociception in rats.MethodsAdult male and female Sprague Dawley rats received three doses of active or control vaccine at weeks 0, 2, and 4. Vaccine pharmacological selectivity was assessed by comparing opioid dose-effect curves in 50°C warm-water tail-withdrawal procedure before and after active or control heroin-TT vaccine. Route of administration [subcutaneous (SC) vs. intravenous [IV)] was also examined as a determinant of vaccine effectiveness. Continuous naltrexone treatment (0.0032-0.032 mg/kg/h) effects on heroin, 6-AM, and morphine antinociceptive potency was also determined as a benchmark for minimal vaccine effectiveness.ResultsThe heroin-TT vaccine decreased potency of SC heroin (5-fold), IV heroin (3-fold), and IV 6-AM (3-fold) for several weeks without affecting IV morphine or SC and IV fentanyl potency. The control vaccine did not alter potency of any opioid. Naltrexone dose-dependently decreased antinociceptive potency of SC heroin, and treatment with 0.01 mg/kg/h naltrexone produced similar, approximate 8-fold decreases in potencies of SC and IV heroin, IV 6-AM, and IV morphine. The combination of naltrexone and active vaccine was more effective than naltrexone alone to antagonize SC heroin but not IV heroin.ConclusionsThe heroin-TT vaccine formulation examined is less effective, but more selective, than chronic naltrexone to attenuate heroin antinociception in rats. Furthermore, these results provide an empirical framework for future preclinical opioid vaccine research to benchmark effectiveness against naltrexone.

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