scholarly journals Tissue-specific Distribution of Genistein, Daidzein and Bisphenol A in Male Sprague-Dawley Rats after Intragastric Administration

2005 ◽  
Vol 11 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Shin YASUDA ◽  
Po-Sheng WU ◽  
Masaaki OKABE ◽  
Hirofumi TACHIBANA ◽  
Koji YAMADA
Keyword(s):  
Bisphenol A ◽  
Intragastric Administration ◽  
Sprague Dawley ◽  
Tissue Specific ◽  
Specific Distribution ◽  
Sprague Dawley Rats

Corticosterone tissue-specific response in Sprague Dawley rats under acute heat stress

2019 ◽  
Vol 81 ◽  
pp. 12-19 ◽  
Author(s):  
Jinhuan Dou ◽  
Yuri R. Montanholi ◽  
Zezhao Wang ◽  
Zhongshu Li ◽  
Ying Yu ◽  
...  
Keyword(s):  
Heat Stress ◽  
Specific Response ◽  
Sprague Dawley ◽  
Tissue Specific ◽  
Sprague Dawley Rats ◽  
Acute Heat Stress

scholarly journals Anti-infertility significance of aqueous extract of I pomoea batatas (L.) Lam. against exposure of bisphenol A (BPA) promoted testicular toxicity in male Sprague Dawley rats

2013 ◽  
Vol 2 (4) ◽  
pp. 263-271
Author(s):  
Rajendran Revathy ◽  
Kulanthaivel Langeswaran ◽  
Subbaraj Gowtham kumar ◽  
Shanmugam Vijayaprakash ◽  
Peranandam Tamilselvan ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Aqueous Extract ◽  
Testicular Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Metabolization of nifurtimox and benznidazole in cellular fractions of rat mammary tissue

2010 ◽  
Vol 29 (10) ◽  
pp. 813-822 ◽  
Author(s):  
Laura Cecilia Bartel ◽  
María Montalto de Mecca ◽  
Carmen Rodríguez de Castro ◽  
Florencia Matilde Bietto ◽  
José Alberto Castro
Keyword(s):  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Protein Carbonyl ◽  
Reduced Form ◽  
Mammary Tissue ◽  
Intragastric Administration ◽  
Lipid Hydroperoxides ◽  
Sprague Dawley ◽  
Protein Carbonyl Content ◽  
Sprague Dawley Rats ◽  
Protein Sulfhydryl

Two nitroheterocyclic drugs, nifurtimox (NFX) and benznidazole (BZ), used in the treatment of Chagas’ disease have serious side effects attributed to their nitroreduction to reactive metabolites. Here, we report that these drugs reach the mammary tissue and there they could undergo in situ bioactivation. Both were detected in mammary tissue from female Sprague-Dawley rats after their intragastric administration. Only NFX was biotransformed by pure xanthine-oxidoreductase and from tissue cytosol. These activities were purine dependent and were inhibited by allopurinol. Also, only NFX was biotransformed by microsomes in the presence of β-nicotinamide adenine dinucleotide phosphate, reduced form (NADPH), and was inhibited by carbon monoxide and partially by diphenyleneiodonium. NFX treatment produced significant decrease in protein sulfhydryl content after 1, 3 and 6 hours; no increases in protein carbonyl content at any time tested and significantly higher levels of lipid hydroperoxides at 3 and 6 hours; besides, ultrastructural observations after 24 hours showed significant differences in epithelial cells compared to control. These findings indicate that NFX might be more deleterious to mammary tissue than BZ and could correlate with early reports on its ability to promote rat mammary tissue toxicity.

MATERNAL-FETAL DISPOSITION OF BISPHENOL A IN PREGNANT SPRAGUE-DAWLEY RATS

2002 ◽  
Vol 65 (5-6) ◽  
pp. 395-406 ◽  
Author(s):  
Beom Soo Shin ◽  
Sun Dong Yoo ◽  
Chang Youn Cho ◽  
Ji Hoon Jung ◽  
Byung Mu Lee ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Lactational transfer of bisphenol A in Sprague–Dawley rats

2010 ◽  
Vol 199 (3) ◽  
pp. 372-376 ◽  
Author(s):  
Daniel R. Doerge ◽  
Michelle Vanlandingham ◽  
Nathan C. Twaddle ◽  
K. Barry Delclos
Keyword(s):  
Bisphenol A ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Lactational Transfer

Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats

2011 ◽  
Vol 255 (3) ◽  
pp. 261-270 ◽  
Author(s):  
Daniel R. Doerge ◽  
Nathan C. Twaddle ◽  
Michelle Vanlandingham ◽  
Ronald P. Brown ◽  
Jeffrey W. Fisher
Keyword(s):  
Bisphenol A ◽  
Sprague Dawley ◽  
Sprague Dawley Rats
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