scholarly journals Visuo-Vestibular Information Processing by Unipolar Brush Cells in the Rabbit Flocculus

2015 ◽  
Vol 14 (5) ◽  
pp. 578-583 ◽  
Author(s):  
Robert A. Hensbroek ◽  
Tom J. H. Ruigrok ◽  
Boeke J. van Beugen ◽  
Jun Maruta ◽  
John I. Simpson
Keyword(s):  
Information Processing ◽  
Brush Cells ◽  
Vestibular Information ◽  
Unipolar Brush Cells

scholarly journals Electrophysiological, Morphological, and Topological Properties of Two Histochemically Distinct Subpopulations of Cerebellar Unipolar Brush Cells

2012 ◽  
Vol 11 (4) ◽  
pp. 1012-1025 ◽  
Author(s):  
Jin-Ah Kim ◽  
Gabriella Sekerková ◽  
Enrico Mugnaini ◽  
Marco Martina
Keyword(s):  
Topological Properties ◽  
Brush Cells ◽  
Unipolar Brush Cells

Resurgent Na Currents in Four Classes of Neurons of the Cerebellum

2004 ◽  
Vol 92 (5) ◽  
pp. 2831-2843 ◽  
Author(s):  
Fatemeh S. Afshari ◽  
Krzysztof Ptak ◽  
Zayd M. Khaliq ◽  
Tina M. Grieco ◽  
N. Traverse Slater ◽  
...  
Keyword(s):  
Open Channel ◽  
Granule Cells ◽  
Na Channel ◽  
Na Channels ◽  
Brush Cells ◽  
Cerebellar Neurons ◽  
Na Currents ◽  
Unipolar Brush Cells ◽  
Resurgent Current ◽  
Resurgent Currents

Action potential firing rates are generally limited by the refractory period, which depends on the recovery from inactivation of voltage-gated Na channels. In cerebellar Purkinje neurons, the kinetics of Na channels appear specialized for rapid firing. Upon depolarization, an endogenous open-channel blocker rapidly terminates current flow but prevents binding of the “fast” inactivation gate. Upon repolarization, unbinding of the blocker produces “resurgent” Na current while allowing channels to recover rapidly. Because other cerebellar neurons, including granule cells, unipolar brush cells, and neurons of the cerebellar nuclei, also fire rapidly, we tested whether these cells might also express Na channels with resurgent kinetics. Neurons were acutely isolated from mice and rats, and TTX-sensitive Na currents were recorded under voltage clamp. Unlike Purkinje cells, the other cerebellar neurons produced only tiny resurgent currents in solutions optimized for voltage-clamping Na currents (50 mM Na+; Co2+ substitution for Ca2+). Under more physiological ionic conditions (155 mM Na+; 2 mM Ca2+ with 0.03 mM Cd2+), however, granule cells, unipolar brush cells, and cerebellar nuclear cells all produced robust resurgent currents. The increase in resurgent current, which was greater than predicted by the Goldman-Hodgkin-Katz equation, appeared to result from a combination of knock-off of open-channel blockers by permeating ions as well as relief of divalent block at negative potentials. These results indicate that resurgent current is typical of many cerebellar neurons and suggest that rapid open-channel block and unblock may be a widespread mechanism for restoration of Na channel availability in rapidly firing neurons.

scholarly journals Forward Signaling by Unipolar Brush Cells in the Mouse Cerebellum

2015 ◽  
Vol 14 (5) ◽  
pp. 528-533 ◽  
Author(s):  
Stijn van Dorp ◽  
Chris I. De Zeeuw
Keyword(s):  
Brush Cells ◽  
Mouse Cerebellum ◽  
Unipolar Brush Cells

scholarly journals Early Onset of Ataxia in Moonwalker Mice Is Accompanied by Complete Ablation of Type II Unipolar Brush Cells and Purkinje Cell Dysfunction

2013 ◽  
Vol 33 (50) ◽  
pp. 19689-19694 ◽  
Author(s):  
G. Sekerkova ◽  
J.-A. Kim ◽  
M. J. Nigro ◽  
E. B. E. Becker ◽  
J. Hartmann ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Early Onset ◽  
Type Ii ◽  
Brush Cells ◽  
Cell Dysfunction ◽  
Complete Ablation ◽  
Unipolar Brush Cells

Oxygen–glucose deprivation increases firing of unipolar brush cells and enhances spontaneous EPSCs in Purkinje cells in the vestibulo-cerebellum

2016 ◽  
Vol 106 ◽  
pp. 1-11
Author(s):  
Yukihiro Takayasu ◽  
Masato Shino ◽  
Osamu Nikkuni ◽  
Yukari Yoshida ◽  
Nobuhiko Furuya ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Brush Cells ◽  
Unipolar Brush Cells
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