mouse cerebellum
Recently Published Documents


TOTAL DOCUMENTS

506
(FIVE YEARS 8)

H-INDEX

55
(FIVE YEARS 0)

2021 ◽  
pp. 136356
Author(s):  
Jin Bai ◽  
Ting Ye ◽  
Yan-bin Wei ◽  
Yi Yang ◽  
He-min Yang ◽  
...  


PLoS Biology ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. e3001297
Author(s):  
Yan Jin ◽  
Bowen Zhang ◽  
Junxia Lu ◽  
Yingdong Song ◽  
Wei Wang ◽  
...  

Recent studies have shown that long noncoding RNAs (lncRNAs) are critical regulators in the central nervous system (CNS). However, their roles in the cerebellum are currently unclear. In this work, we identified the isoform 204 of lncRNA Gm2694 (designated as lncRNA-Promoting Methylation (lncRNA-PM)) is highly expressed in the cerebellum and derived from the antisense strand of the upstream region of Cerebellin-1 (Cbln1), a well-known critical cerebellar synaptic organizer. LncRNA-PM exhibits similar spatiotemporal expression pattern as Cbln1 in the postnatal mouse cerebellum and activates the transcription of Cbln1 through Pax6/Mll1-mediated H3K4me3. In mouse cerebellum, lncRNA-PM, Pax6/Mll1, and H3K4me3 are all associated with the regulatory regions of Cbln1. Knockdown of lncRNA-PM in cerebellum causes deficiencies in Cbln1 expression, cerebellar synaptic integrity, and motor function. Together, our work reveals an lncRNA-mediated transcriptional activation of Cbln1 through Pax6-Mll1-H3K4me3 and provides novel insights of the essential roles of lncRNA in the cerebellum.



2021 ◽  
Vol 7 (26) ◽  
pp. eabd2781
Author(s):  
Claudio Ballabio ◽  
Matteo Gianesello ◽  
Chiara Lago ◽  
Konstantin Okonechnikov ◽  
Marica Anderle ◽  
...  

The identity of the cell of origin is a key determinant of cancer subtype, progression, and prognosis. Group 3 medulloblastoma (MB) is a malignant childhood brain cancer with poor prognosis and few candidates as putative cell of origin. We overexpressed the group 3 MB genetic drivers MYC and Gfi1 in different candidate cells of origin in the postnatal mouse cerebellum. We found that S100b+ cells are competent to initiate group 3 MB, and we observed that S100b+ cells have higher levels of Notch1 pathway activity compared to Math1+ cells. We found that additional activation of Notch1 in Math1+ and Sox2+ cells was sufficient to induce group 3 MB upon MYC/Gfi1 expression. Together, our data suggest that the Notch1 pathway plays a critical role in group 3 MB initiation.



2021 ◽  
Vol 2 (2) ◽  
pp. 100409
Author(s):  
Yijun Yang ◽  
Yanghui Qu ◽  
Yan Cheng ◽  
Duancheng Guo ◽  
Qianhai Fan ◽  
...  
Keyword(s):  


2021 ◽  
Author(s):  
Maria M. Bayliak ◽  
Nadia M. Mosiichuk ◽  
Oksana M. Sorochynska ◽  
Oksana V. Kuzniak ◽  
Lesia O. Sishchuk ◽  
...  


2021 ◽  
Author(s):  
Owen Y. Chao ◽  
Hao Zhang ◽  
Salil Saurav Pathak ◽  
Joseph P. Huston ◽  
Yi-Mei Yang


2021 ◽  
Author(s):  
Ioannis Sarropoulos ◽  
Mari Sepp ◽  
Robert Frömel ◽  
Kevin Leiss ◽  
Nils Trost ◽  
...  

AbstractOrgan development is orchestrated by cell- and time-specific gene regulatory networks. Here we investigated the regulatory basis of mouse cerebellum development from early neurogenesis to adulthood. By acquiring snATAC-seq profiles for ~90,000 cells spanning eleven stages, we mapped all major cerebellar cell types and identified candidate cis-regulatory elements (CREs). We detected extensive spatiotemporal heterogeneity among progenitor cells and characterized the regulatory programs underlying the differentiation of cerebellar neurons. Although CRE activity is predominantly cell type- and time-specific, periods of greater regulatory change are shared across cell types. There is a universal decrease in CRE conservation and pleiotropy during development and differentiation, but the degree of evolutionary constraint differs between cerebellar cell types. Our work delineates the developmental and evolutionary dynamics of gene regulation in cerebellar cells and provides general insights into mammalian organ development.



2021 ◽  
Vol 142 ◽  
pp. 104920
Author(s):  
Emma Balog ◽  
Gyula Jenei ◽  
Levente Gellért ◽  
Etsuro Ono ◽  
László Vécsei ◽  
...  


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Lorenzo Massimi ◽  
Nicola Pieroni ◽  
Laura Maugeri ◽  
Michela Fratini ◽  
Francesco Brun ◽  
...  


2020 ◽  
Author(s):  
Claudio Ballabio ◽  
Matteo Gianesello ◽  
Chiara Lago ◽  
Konstantin Okonechnikov ◽  
Marica Anderle ◽  
...  

SummaryThe identity of the cell of origin is a key determinant of cancer subtype, progression and prognosis. Group 3 Medulloblastoma (MB) is a malignant childhood brain cancer with poor prognosis and unknown cell of origin. We overexpressed the Group 3 MB genetic drivers MYC and Gfi1 in different candidate cells of origin in the postnatal mouse cerebellum. We found that S100b+ cells are competent to initiate Group 3 MB, while Math1+, Sox2+ or Ascl1+ cells are not. We noted that S100b+ cells have higher levels of Notch1 pathway activity compared to Math1+ cells. Interestingly, we found that additional activation of Notch1 in Math1+ cells was sufficient to induce Group 3 MB upon MYC/Gfi1 expression. Taken together, our data suggest that the MB cell of origin competence depends on the cellular identity, which relies on Notch1 activity.Graphical Abstract



Sign in / Sign up

Export Citation Format

Share Document