Impairments in Walking Ability, Dexterity, and Cognitive Function in Multiple Sclerosis Are Associated with Different Regional Cerebellar Gray Matter Loss

2017 ◽  
Vol 16 (5-6) ◽  
pp. 945-950 ◽  
Author(s):  
Matthias Grothe ◽  
Martin Lotze ◽  
Sönke Langner ◽  
Alexander Dressel
2017 ◽  
Vol 128 (10) ◽  
pp. e327
Author(s):  
M. Grothe ◽  
M. Süße ◽  
F. von Podewils ◽  
S. Langner ◽  
M. Lotze ◽  
...  

2005 ◽  
Vol 53 (5) ◽  
pp. 323 ◽  
Author(s):  
Seon Hyeong Choi ◽  
Won Jin Moon ◽  
Eun Chul Chung ◽  
Min Hee Lee ◽  
Hong Gee Roh ◽  
...  

2017 ◽  
Vol 24 (9) ◽  
pp. 1163-1173 ◽  
Author(s):  
Martin Weygandt ◽  
Katharina Wakonig ◽  
Janina Behrens ◽  
Lil Meyer-Arndt ◽  
Eveline Söder ◽  
...  

Background: Decision-making (DM) abilities deteriorate with multiple sclerosis (MS) disease progression which impairs everyday life and is thus clinically important. Objective: To investigate the underlying neurocognitive processes and their relation to regional gray matter (GM) loss induced by MS. Methods: We used a functional magnetic resonance imaging (fMRI) Iowa Gambling Task to measure DM-related brain activity in 36 MS patients and 21 healthy controls (HC). From this activity, we determined neural parameters of two cognitive stages, a deliberation (“choice”) period preceding a choice and a post-choice (“feedback”) stage reporting decision outcomes. These measures were related to DM separately in intact and damaged GM areas as determined by a voxel-based morphometry analysis. Results: Severely affected patients (with high lesion burden) showed worse DM-learning than HC ( t = −1.75, p = 0.045), moderately affected (low lesion burden) did not. Activity in the choice stage in intact insular ( t = 4.60, pFamily-Wise Error [FWE] corrected = 0.034), anterior cingulate ( t = 4.50, pFWE = 0.044), and dorsolateral prefrontal areas ( t = 4.43, pFWE = 0.049) and in insular areas with GM loss ( t = 3.78, pFWE = 0.011) was positively linked to DM performance across patients with severe tissue damage and HC. Furthermore, activity in intact orbitofrontal areas was positively linked to DM-learning during the feedback stage across these participants ( t = 4.49, pFWE = 0.032). During none of the stages, moderately affected patients showed higher activity than HC, which might have indicated preserved DM due to compensatory activity. Conclusion: We identified dysregulated activity linked to impairment in specific cognitive stages of reward-related DM. The link of brain activity and impaired DM in areas with MS-induced GM loss suggests that this deficit might be tightly coupled to MS neuropathology.


2016 ◽  
Vol 73 (8) ◽  
pp. 944 ◽  
Author(s):  
Allan MacKenzie-Graham ◽  
Florian Kurth ◽  
Yuichiro Itoh ◽  
He-Jing Wang ◽  
Michael J. Montag ◽  
...  

Neurology ◽  
2008 ◽  
Vol 70 (Issue 13, Part 2) ◽  
pp. 1107-1112 ◽  
Author(s):  
S. Mesaros ◽  
M. A. Rocca ◽  
M. Absinta ◽  
A. Ghezzi ◽  
N. Milani ◽  
...  

2020 ◽  
Vol 267 (6) ◽  
pp. 1824-1829
Author(s):  
Monica Margoni ◽  
Silvia Franciotta ◽  
Davide Poggiali ◽  
Alice Riccardi ◽  
Francesca Rinaldi ◽  
...  

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