A case of intraductal papillary mucinous neoplasm developing in the native pancreas after pancreas transplantation treated by total pancreatectomy

2021 ◽  
Author(s):  
Hiromichi Sato ◽  
Yoshito Tomimaru ◽  
Hirofumi Akita ◽  
Shogo Kobayashi ◽  
Toshinori Ito ◽  
...  
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Pancreas Transplantation ◽  
Total Pancreatectomy ◽  
Mucinous Neoplasm

scholarly journals Favorable Response After Gemcitabine-Radiotherapy for Invasive Pancreatic Intraductal Papillary Mucinous Neoplasm: A Case Report

2013 ◽  
Vol 98 (4) ◽  
pp. 340-345 ◽  
Author(s):  
Takanori Ochiai ◽  
Kimihiro Igari ◽  
Takaki Furuyama ◽  
Hiromitsu Ito ◽  
Yusuke Mitsunori ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Ductal Carcinoma ◽  
Total Pancreatectomy ◽  
Surgical Margin ◽  
Resected Specimen ◽  
Pancreatic Ductal Carcinoma ◽  
Positive Surgical Margin ◽  
Mucinous Neoplasm ◽  
Remnant Pancreas

Abstract The efficacy of chemoradiotherapy for invasive pancreatic ductal carcinoma derived from an intraductal papillary mucinous neoplasm (IPMN) has not been established. The subject of the present report was a 53-year-old man admitted for the treatment of IPMN. The tumor, located in the pancreatic body, was of the mixed type of IPMN, and it involved the branch duct, where it was 38 mm in diameter, and the main duct, where it was 6 mm in diameter. Distal pancreatectomy was performed and the postoperative course was uneventful; however, histopathologic diagnosis revealed invasive ductal carcinoma with a positive surgical margin in the pancreatic duct. Although total pancreatectomy was recommended, chemoradiotherapy (50.4-Gy irradiation and gemcitabine) was preferred by the patient. At 9-month follow up, computed tomography and magnetic resonance imaging showed a cystic mass at the surgical margin of the pancreas. Endoscopic ultrasonography showed a 44-mm cystic lesion with nodules in the remnant pancreas, on the basis of which he underwent total pancreatectomy. Pathologic examination of the resected specimen revealed absence of the epithelium at the surgical margin of the main pancreatic duct, and malignant cells were not detected.

scholarly journals Total Pancreatectomy for Malignant Intraductal Papillary Mucinous Neoplasm (IPMN) Complicated by Gastropancreatic Fistulae

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Oshan Basnayake ◽  
Pradeep Wijerathne ◽  
Umesh Jayarajah ◽  
Nilesh Fernandopulle ◽  
Sivasuriya Sivaganesh
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Total Pancreatectomy ◽  
Epigastric Pain ◽  
Past History ◽  
Ductal Adenocarcinoma ◽  
Fistula Formation ◽  
Oral Contrast ◽  
High Grade ◽  
Recurrent Acute Pancreatitis ◽  
Mucinous Neoplasm

Background. Intraductal papillary mucinous neoplasms (IPMN) of the pancreas complicated by fistula formation to adjacent organs are an uncommon phenomenon. We present an IPMN of the pancreas with malignant transformation and multiple fistulae to the stomach and duodenum. Case Presentation. A 50-year-old female was referred for investigation of recent epigastric pain and a past history of recurrent pancreatitis. Imaging with computed tomography showed a gross dilatation of the entire pancreatic duct with a heterogeneous enhancement of the periductal parenchyma. A passage of oral contrast was noted from the greater curvature and pylorus of the stomach into the dilated duct suggestive of fistulae formation. Gastroduodenoscopy demonstrated these fistulae in the stomach and the proximal duodenum and an exophytic growth at the ampulla obliterating the view of ampullary opening. Endosonography- (EUS-) guided fine-needle aspiration cytology (FNAC) showed cells with high-grade atypia. A total pancreatectomy, distal gastrectomy, and splenectomy were performed, and recovery was uneventful. Histology revealed a ductal adenocarcinoma arising from an intestinal type intraductal papillary mucinous neoplasm with high-grade dysplasia. A year and a half after surgery, she is healthy with good glycaemic control and nutritional status. Conclusion. This case highlights the importance investigating patients for the aetiology in recurrent acute pancreatitis and their follow-up. Awareness of cystic pancreatic neoplasms including IPMN is important to avoid misdiagnosis or delayed diagnosis. Referral of these patients to centres with facilities for multidisciplinary input and specialised management is strongly recommended.

scholarly journals Pylorus-preserving total pancreatectomy for an intraductal papillary-mucinous neoplasm of the pancreas

2007 ◽  
Vol 14 (3) ◽  
pp. 264-269 ◽  
Author(s):  
Mitsuhiro Inagaki ◽  
Mitsuhiro Obara ◽  
Shuichi Kino ◽  
Junichi Goto ◽  
Shigeki Suzuki ◽  
...  
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Total Pancreatectomy ◽  
Mucinous Neoplasm

Glycemic Control in Patients Post Total Pancreatectomy (TP) for Intraductal Papillary Mucinous Neoplasm (IPMN)

2008 ◽  
Vol 103 ◽  
pp. S74-S75
Author(s):  
Laith Jamil ◽  
John Stauffer ◽  
Shon Meek ◽  
Kanwar Gill ◽  
Massimo Raimondo ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Total Pancreatectomy ◽  
Mucinous Neoplasm

scholarly journals Hand-assisted laparoscopic total pancreatectomy for a main duct intraductal papillary mucinous neoplasm of the pancreas

Surgery Today ◽  
2011 ◽  
Vol 41 (2) ◽  
pp. 306-310 ◽  
Author(s):  
Amane Kitasato ◽  
Yoshitsugu Tajima ◽  
Tamotsu Kuroki ◽  
Tomohiko Adachi ◽  
Takashi Kanematsu
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Total Pancreatectomy ◽  
Main Duct ◽  
Mucinous Neoplasm

scholarly journals Robotic total pancreatectomy with splenectomy for multifocal intraductal papillary mucinous neoplasm

HPB ◽  
2017 ◽  
Vol 19 ◽  
pp. S112-S113
Author(s):  
I. Konstantinidis ◽  
F. Tozzi ◽  
S. Warner ◽  
L. Melstrom ◽  
Y. Woo ◽  
...  
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Total Pancreatectomy ◽  
Mucinous Neoplasm

scholarly journals Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study

HPB Surgery ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Laith H. Jamil ◽  
Ana M. Chindris ◽  
Kanwar R. S. Gill ◽  
Daniela Scimeca ◽  
John A. Stauffer ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Hemoglobin A1c ◽  
Total Pancreatectomy ◽  
Control Group ◽  
Type I ◽  
Mucinous Neoplasm ◽  
Point Of Interest ◽  
Type 1 Dm

Background. Glycemic control following total pancreatectomy (TP) has been thought to be difficult to manage. Diffuse intraductal papillary mucinous neoplasm (IPMN) is a potentially curable precursor to pancreatic adenocarcinoma, best treated by TP. Objective. Compare glycemic control in patients undergoing TP for IPMN to patients with type 1 diabetes mellitus (DM). Design/Setting. Retrospective cohort. Outcome Measure. Hemoglobin A1C(HbA1C) at 6, 12, 18, and 24 months after TP. In the control group, baseline was defined as 6 months prior to the first HbA1c measure. Results. Mean HgbA1C at each point of interest was similar between TP and type I DM patients (6 months (7.5% versus 7.7%, P=0.52), 12 months (7.3% versus 8.0%, P=0.081), 18 months (7.7% and 7.6%, P=0.64), and at 24 months (7.3% versus 7.8%, P=0.10)). Seven TP patients (50%) experienced a hypoglycemic event compared to 65 type 1 DM patients (65%, P=0.38). Limitations. Small number of TP patients, retrospective design, lack of long-termfollowup. Conclusion. This suggests that glycemic control following TP for IPMNcan be well managed, similar to type 1 DM patients. Fear of DM following TP for IPMN should not preclude surgery when TP is indicated.

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