Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study

Background. Glycemic control following total pancreatectomy (TP) has been thought to be difficult to manage. Diffuse intraductal papillary mucinous neoplasm (IPMN) is a potentially curable precursor to pancreatic adenocarcinoma, best treated by TP. Objective. Compare glycemic control in patients undergoing TP for IPMN to patients with type 1 diabetes mellitus (DM). Design/Setting. Retrospective cohort. Outcome Measure. Hemoglobin A1C(HbA1C) at 6, 12, 18, and 24 months after TP. In the control group, baseline was defined as 6 months prior to the first HbA1c measure. Results. Mean HgbA1C at each point of interest was similar between TP and type I DM patients (6 months (7.5% versus 7.7%, P=0.52), 12 months (7.3% versus 8.0%, P=0.081), 18 months (7.7% and 7.6%, P=0.64), and at 24 months (7.3% versus 7.8%, P=0.10)). Seven TP patients (50%) experienced a hypoglycemic event compared to 65 type 1 DM patients (65%, P=0.38). Limitations. Small number of TP patients, retrospective design, lack of long-termfollowup. Conclusion. This suggests that glycemic control following TP for IPMNcan be well managed, similar to type 1 DM patients. Fear of DM following TP for IPMN should not preclude surgery when TP is indicated.

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Long Term Glycemic Control is Similar Between Type 1 DM Patients and Patients Post Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm (IPMN)

The American Journal of Gastroenterology ◽

10.14309/00000434-200910003-00232 ◽

2009 ◽

Vol 104 ◽

pp. S89

Author(s):

Laith Jamil ◽

Ana Maria Chindris ◽

John Stauffer ◽

Kanwar Gill ◽

Shon Meek ◽

...

Keyword(s):

Glycemic Control ◽

Intraductal Papillary Mucinous Neoplasm ◽

Total Pancreatectomy ◽

Mucinous Neoplasm ◽

Type 1 Dm

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Glycemic Control in Patients Post Total Pancreatectomy (TP) for Intraductal Papillary Mucinous Neoplasm (IPMN)

The American Journal of Gastroenterology ◽

10.14309/00000434-200809001-00192 ◽

2008 ◽

Vol 103 ◽

pp. S74-S75

Author(s):

Laith Jamil ◽

John Stauffer ◽

Shon Meek ◽

Kanwar Gill ◽

Massimo Raimondo ◽

...

Keyword(s):

Glycemic Control ◽

Intraductal Papillary Mucinous Neoplasm ◽

Total Pancreatectomy ◽

Mucinous Neoplasm

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S1299 Glycemic Control in Patients Post Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm (IPMN)

Gastroenterology ◽

10.1016/s0016-5085(09)61048-9 ◽

2009 ◽

Vol 136 (5) ◽

pp. A-232

Author(s):

Ana M. Chindris ◽

Laith H. Jamil ◽

John Stauffer ◽

Kanwar R. Gill ◽

Daniela Scimeca ◽

...

Keyword(s):

Glycemic Control ◽

Intraductal Papillary Mucinous Neoplasm ◽

Total Pancreatectomy ◽

Mucinous Neoplasm

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Abstract #247 Assessment of Disturbed Eating Behaviors Using Deps-R and its Relationship with Glycemic Control in Young Indian Type 1 Dm Patients

Endocrine Practice ◽

10.1016/s1530-891x(20)46591-7 ◽

2019 ◽

Vol 25 ◽

pp. 92

Author(s):

Vipan Talwar ◽

Gourav Talwar ◽

Shria Talwar ◽

Rohit Kapoor

Keyword(s):

Glycemic Control ◽

Eating Behaviors ◽

Disturbed Eating ◽

Type 1 Dm

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Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

Open Medicine ◽

10.2478/s11536-009-0080-z ◽

2009 ◽

Vol 4 (4) ◽

pp. 415-422

Author(s):

Kamile Gul ◽

Ihsan Ustun ◽

Yusuf Aydin ◽

Dilek Berker ◽

Halil Erol ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Statistical Significance ◽

Control Group ◽

Acid Decarboxylase ◽

Thyroid Peroxidase ◽

The Difference ◽

Type 1 Dm

AbstractThe aim of the study was to determine the frequency and titers of anti-thyroid peroxidase (Anti-TPO), anti-thyroglobulin (Anti-TG), and anti-glutamic acid decarboxylase (Anti-GAD) antibodies in Turkish patients with type 1 diabetes mellitus (DM), and to compare the frequency of anti-TPO and anti-TG titers in the presence or absence of anti-GAD. A total of 104 patients including 56 males and 48 females with type 1 DM and their age-, gender-, and body mass index-matched control group, including 31 males and 27 females, 58 cases in total with an age range of 15-50 years, were recruited into this study. In patients with type 1 DM, positive anti-GAD was detected in 30.8% (n=32). In patients with positive anti-GAD, rate of positive anti-TPO was 37.5%; however, in patients with negative anti-GAD, the rate of positive anti-TPO was 9.7% and the difference was statistically significant (p=0.001). In patients with positive anti-GAD, the rate of positive anti-TG was 18.8%. In patients with negative anti-GAD, the rate of positive anti-TG was 2.8%, and the difference between them was statistically significant (p=0.005). In patients with positive and negative anti-GAD, rates of both positive anti-TPO and anti-TG were 15.6% and 1.4%, respectively, with the difference showing statistical significance (p=0.004). Thyroid autoimmunity in type 1 DM patients with positive anti-GAD was apparently higher; therefore, these patients should be followed more frequently and carefully.

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Effect of high-intensity interval training on glycemic control in adults with type 1 diabetes with overweight or obesity: a randomized controlled trial with partial cross-over

10.2337/figshare.12515424 ◽

2020 ◽

Author(s):

Angela S Lee ◽

Nathan A Johnson ◽

Margaret McGill ◽

Jane Overland ◽

Connie Luo ◽

...

Keyword(s):

Type 1 Diabetes ◽

Glycemic Control ◽

High Intensity ◽

Intervention Group ◽

Interval Training ◽

Control Group ◽

High Intensity Interval Training ◽

High Intensity Interval ◽

Overweight Or Obesity

Objective: To study the effect of 12 weeks of high-intensity interval training (HIIT) on glycemic control in adults with type 1 diabetes with overweight or obesity. Research Design and Methods: Thirty inactive adults with type 1 diabetes who had BMI≥25kg/m2 and HbA1c≥7.5% were randomized to 12 weeks of either: HIIT exercise intervention consisting of 4x4 minutes HIIT (85-95% HRpeak) performed thrice weekly, or usual care control. In a partial cross-over design, the control group subsequently performed the 12-week HIIT intervention. The primary endpoint was the change in HbA1c from baseline to 12 weeks. Glycemic and cardiometabolic outcomes were measured at 0, 12, and 24 weeks. Results: Participants were aged 44±10 years, with diabetes duration 19±11 years, and BMI 30.1±3.1 kg/m2. HbA1c decreased from 8.63 ± 0.66% at baseline to 8.10 ± 1.04% at 12 weeks in the HIIT intervention group (p=0.01), however this change was not significantly different to the control group (HIIT -0.53 ± 0.61%, control -0.14 ± 0.48%, p=0.08). In participants who undertook at least 50% of the prescribed HIIT intervention, the HbA1c reduction was significantly greater than control (HIIT -0.64 ± 0.64% (n=9), control -0.14 ± 0.48% (n=15), p=0.04). There were no differences in insulin dose, hypoglycemia on continuous glucose monitoring, blood pressure, blood lipids, body weight or body composition between groups. Conclusions: <a>Overall, there was no significant reduction in HbA1c with a 12-week HIIT intervention in adults with type 1 diabetes. However glycaemic control may improve for people who undertake HIIT with greater adherence.</a>

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Type I Diabetes Mellitus

10.2310/im.4017 ◽

2019 ◽

Author(s):

Joseph I. Wolfsdorf ◽

Katharine Garvey

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Type 1 Diabetes Mellitus ◽

Diabetic Ketoacidosis ◽

Autoimmune Diabetes ◽

Type I ◽

Insulin Deficiency ◽

Glucose Levels

Type 1 diabetes mellitus is characterized by severe insulin deficiency, making patients dependent on exogenous insulin replacement for survival. These patients can experience life-threatening events when their glucose levels are significantly abnormal. Type 1 diabetes accounts for 5 to 10% of all diabetes cases, with type 2 accounting for most of the remainder. This review details the pathophysiology, stabilization and assessment, diagnosis and treatment, disposition and outcomes of patients with Type 1 diabetes mellitus. Figures show the opposing actions of insulin and glucagon on substrate flow and plasma levels; plasma glucose, insulin and C-peptide levels throughout the day; the structure of human proinsulin; current view of the pathogenesis of Type 1 autoimmune diabetes mellitus; pathways that lead from insulin deficiency to the major clinical manifestations of Type 1 diabetes mellitus; relationship between hemoglobin A1c values at the end of a 3-month period and calculated average glucose levels during the 3-month period; different combinations of various insulin preparations used to establish glycemic control; and basal-bolus and insulin pump regimens. Tables list the etiologic classification of Type 1 diabetes mellitus, typical laboratory findings and monitoring in diabetic ketoacidosis, criteria for the diagnosis of Type 1 diabetes, clinical goals of Type 1 diabetes treatment, and insulin preparations. This review contains 10 figures, 9 tables, and 40 references. Keywords: Type 1 diabetes mellitus, optimal glycemic control, hypoglycemia, hyperglycemia, polyuria, polydipsia, polyphagia, HbA1c, medical nutrition therapy, Diabetic Ketoacidosis

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A case of intraductal papillary mucinous neoplasm developing in the native pancreas after pancreas transplantation treated by total pancreatectomy

Clinical Journal of Gastroenterology ◽

10.1007/s12328-021-01517-0 ◽

2021 ◽

Author(s):

Hiromichi Sato ◽

Yoshito Tomimaru ◽

Hirofumi Akita ◽

Shogo Kobayashi ◽

Toshinori Ito ◽

...

Keyword(s):

Intraductal Papillary Mucinous Neoplasm ◽

Pancreas Transplantation ◽

Total Pancreatectomy ◽

Mucinous Neoplasm

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Risk of Urticaria in Children with Type 1 Diabetes Mellitus: A Nationwide Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17010176 ◽

2019 ◽

Vol 17 (1) ◽

pp. 176

Author(s):

Shih-Yi Lin ◽

Cheng-Li Lin ◽

Cheng-Chieh Lin ◽

Wu-Huei Hsu ◽

Chung-Y. Hsu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Hazard Ratio ◽

Control Group ◽

Case Group ◽

Research Database ◽

Increased Risk ◽

Type 1 Dm

Type 1 diabetes mellitus (T1DM) has been linked to many autoimmune problems. The association between T1DM and urticaria warrants investigation. Data were extracted from the National Health Insurance Research Database (NHIRD) of Taiwan. Participants with T1DM were recruited as the case group, and that group was matched by sex and age at a ratio of 1:4 to the control group comprising those without T1DM. The study period was 1998–2011. All participants were followed up to the diagnosis of urticaria, withdrawal from the insurance program, death, or the end of the study. A multivariable Cox proportional hazard model was used to calculate the adjusted and crude hazard ratios for urticaria. A total of 5895 participants (1179 in the case group and 4716 in the control group) were followed up in the study. The total incidence rate of urticaria in patients with type 1 DM was 26.6 per 1000 person-years, and that in controls was 6.85 per 1000 person-years. Compared with the control group, the hazard ratio of urticaria in the case group was 2.84 (95% CI = 2.27–3.56). Compared with age-matched participants without T1DM, patients with type 1 DM aged <18 years had a 3.62-fold higher risk of urticaria (95% CI = 2.85–4.59). The hazard ratio in patients with an adjusted Diabetes Complications Severity Index (aDCSI) score of 1.01–2.00 per year was 2.57 (95% CI = 1.18–5.57), and that in patients with an aDCSI score of >2.00 per year was 4.47 (95% CI = 2.68–7.47). T1DM patients aged <18 years had an increased risk of urticaria, but a similar phenomenon was not observed among T1DM patients older than 18 years.

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