Chest CT features of children infected by B.1.617.2 (Delta) variant of COVID-19

Abstract Background Since the announcement of COVID-19 as a pandemic infection, several studies have been performed to discuss the clinical picture, laboratory finding, and imaging features of this disease. The aim of this study is to demarcate the imaging features of novel coronavirus infected pneumonia (NCIP) in different age groups and outline the relation between radiological aspect, including CT severity, and clinical aspect, including age, oxygen saturation, and fatal outcome. We implemented a prospective observational study enrolled 299 laboratory-confirmed COVID-19 patients (169 males and 130 females; age range = 2–91 years; mean age = 38.4 ± 17.2). All patients were submitted to chest CT with multi-planar reconstruction. The imaging features of NCIP in different age groups were described. The relations between CT severity and age, oxygen saturation, and fatal outcome were evaluated. Results The most predominant CT features were bilateral (75.4%), posterior (66.3%), pleural-based (93.5%), lower lobe involvement (89.8%), and ground-glass opacity (94.7%). ROC curve analysis revealed that the optimal cutoff age that was highly exposed to moderate and severe stages of NCIP was 38 years old (AUC = 0.77, p < 0.001). NCIP was noted in 42.6% below 40-year-old age group compared to 84% above 40-year-old age group. The CT severity was significantly related to age and fatal outcome (p < 0.001). Anterior, centrilobular, hilar, apical, and middle lobe involvements had a significant relation to below 90% oxygen saturation. A significant negative correlation was found between CT severity and oxygen saturation (r = − 0.49, p < 0.001). Crazy-paving pattern, anterior aspect, hilar, centrilobular involvement, and moderate and severe stages had a statistically significant relation to higher mortality. Conclusion The current study confirmed the value of CT as a prognostic predictor in NCIP through demonstration of the strong relation between CT severity and age, oxygen saturation, and the fatal outcome. In the era of COVID-19 pandemic, this study is considered to be an extension to other studies discussing chest CT features of COVID-19 in different age groups with demarcation of the relation of chest CT severity to different pattern and distribution of NCIP, age, oxygen saturation, and mortality rate.

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A family case of COVID-19 pneumonia with different chest CT features and duration of SARS-CoV-2 shedding: a case report from Japan

Japanese Journal of Infectious Diseases ◽

10.7883/yoken.jjid.2021.019 ◽

2021 ◽

Author(s):

Shigeki Ochiai ◽

Yuichi Kama ◽

Kota Hirai ◽

Hidetoshi Yano ◽

Ayumi Tada ◽

...

Keyword(s):

Case Report ◽

Chest Ct ◽

Family Case ◽

Ct Features

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Association between chest CT features and clinical course of Coronavirus Disease 2019

Respiratory Medicine ◽

10.1016/j.rmed.2020.105989 ◽

2020 ◽

Vol 168 ◽

pp. 105989 ◽

Cited By ~ 2

Author(s):

Zhibing Luo ◽

Na Wang ◽

Ping Liu ◽

Qian Guo ◽

Linyu Ran ◽

...

Keyword(s):

Clinical Course ◽

Chest Ct ◽

Ct Features

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Chest CT Features of COVID-19 in Rome, Italy

Radiology ◽

10.1148/radiol.2020201237 ◽

2020 ◽

Vol 296 (2) ◽

pp. E79-E85 ◽

Cited By ~ 139

Author(s):

Damiano Caruso ◽

Marta Zerunian ◽

Michela Polici ◽

Francesco Pucciarelli ◽

Tiziano Polidori ◽

...

Keyword(s):

Chest Ct ◽

Ct Features

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Positive Chest CT Features in Patients With COVID-19 Pneumonia and Negative Real-Time Polymerase Chain Reaction Test

Cureus ◽

10.7759/cureus.9942 ◽

2020 ◽

Cited By ~ 2

Author(s):

Emre Pakdemirli ◽

Uday Mandalia ◽

Sherif Monib

Keyword(s):

Polymerase Chain Reaction ◽

Real Time ◽

Chest Ct ◽

Polymerase Chain Reaction Test ◽

Chain Reaction ◽

Reaction Test ◽

Polymerase Chain ◽

Chain Reaction Test ◽

Ct Features

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Early chest computed tomography to diagnose COVID-19 from suspected patients: A multicenter retrospective study

10.1101/2020.03.24.20042432 ◽

2020 ◽

Cited By ~ 3

Author(s):

Congliang Miao ◽

Mengdi Jin ◽

Li Miao ◽

Xinying Yang ◽

Peng Huang ◽

...

Keyword(s):

Ground Glass Opacity ◽

High Specificity ◽

Diagnostic Value ◽

Chest Ct ◽

Imaging Features ◽

Rt Pcr ◽

Polymerase Chain ◽

Low Sensitivity ◽

Chest Ct Scan ◽

Ct Features

AbstractObjectiveThe purpose of this study is to distinguish the imaging features of COVID-19 with other chest infectious diseases and evaluate diagnostic value of chest CT for suspected patients.MethodsAdult suspected patients aged>18 years within 14 days who underwent chest CT scan and reverse-transcription polymerase-chain-reaction (RT-PCR) tests were enrolled. The enrolled patients were confirmed and grouped according to results of RT-PCR tests. The data of basic demographics, single chest CT features, and combined chest CT features were analyzed for confirmed and non-confirmed groups.ResultsA total of 130 patients were enrolled with 54 cases positive and 76 cases negative. The typical CT imaging features of positive group were ground glass opacity (GGO), crazy-paving pattern and air bronchogram. The lesions were mostly distributed bilaterally, close to the lower lungs or the pleura. When features combined, GGO with bilateral pulmonary distribution and GGO with pleural distribution were more common, of which were 31 cases (57.4%) and 30 cases (55.6%) respectively. The combinations were almost presented statistically significant (P<0.05) except for the combination of GGO with consolidation. Most combinations presented relatively low sensitivity but extremely high specificity. The average specificity of these combinations is around 90%.ConclusionsThe combinations of GGO could be useful in the identification and differential diagnosis of COVID-19, which alerts clinicians to isolate patients for treatment promptly and repeat RT-PCR tests until incubation ends.

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