HODD: A Manually Curated Database of Human Ophthalmic Diseases with Symptom Characteristics and Genetic Variants Towards Facilitating Quick and Definite Diagnosis

Author(s):  
Zhaotian Zhang ◽  
Qiang Tang ◽  
Qiong Wang ◽  
Fulei Nie ◽  
Limei Sun ◽  
...  
2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.


2016 ◽  
Vol 64 (S 01) ◽  
Author(s):  
M. Dreßen ◽  
H. Lahm ◽  
K. Adamzcyk-Wolf ◽  
J. Cleuziou ◽  
J. Kasnar-Samprec ◽  
...  
Keyword(s):  

1973 ◽  
Vol 30 (01) ◽  
pp. 001-001
Author(s):  
Rosemary Biggs

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