Insulin Receptor Genetic Variants Linked to Type 2 Diabetes

2011 ◽  
Vol 41 (5) ◽  
pp. 17
Author(s):  
SHARON WORCESTER
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Receptor ◽  
Genetic Variants

scholarly journals Correction to: Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population

Endocrine ◽  
2020 ◽  
Vol 67 (3) ◽  
pp. 733-733
Author(s):  
Khalid Khalaf Alharbi ◽  
Imran Ali Khan ◽  
Anjana Munshi ◽  
Fawiziah Khalaf Alharbi ◽  
Yazeed Al-Sheikh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Receptor ◽  
Genetic Variants ◽  
Insulin Receptor Substrate ◽  
Saudi Population ◽  
Insulin Receptor Substrate 1

Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population

Endocrine ◽  
2014 ◽  
Vol 47 (2) ◽  
pp. 472-477 ◽  
Author(s):  
Khalid Khalaf Alharbi ◽  
Imran Ali Khan ◽  
Anjana Munshi ◽  
Fawiziah Khalaf Alharbi ◽  
Yazeed Al-Sheikh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Receptor ◽  
Genetic Variants ◽  
Insulin Receptor Substrate ◽  
Saudi Population ◽  
Insulin Receptor Substrate 1

110-OR: Type 2 Diabetes (T2D)–Associated TCF7L2 Genetic Variants and Indices of Insulin Secretion and Sensitivity in Individuals at Risk for Type 1 Diabetes (T1D)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 110-OR
Author(s):  
MARIA J. REDONDO ◽  
MEGAN V. WARNOCK ◽  
LAURA E. BOCCHINO ◽  
SUSAN GEYER ◽  
ALBERTO PUGLIESE ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
At Risk ◽  
Type 1 Diabetes ◽  
Insulin Secretion ◽  
Genetic Variants

Established Type 2 Diabetes–Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review

2018 ◽  
pp. 57-65
Author(s):  
Khalid Siddiqui ◽  
Mohthash Musambil ◽  
Adnan Usmani
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Diabetes Susceptibility

Echinops Spp. Polysaccharide B Ameliorates Metabolic Abnormalities in a Rat Model of Type 2 Diabetes Mellitus

2020 ◽  
Vol 19 (1) ◽  
pp. 106-114
Author(s):  
Guang Hao ◽  
Xiaoyu Ma ◽  
Mengru Jiang ◽  
Zhenzhen Gao ◽  
Ying Yang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Secretion ◽  
Insulin Receptor ◽  
Skeletal Muscles ◽  
Insulin Receptor Substrate ◽  
Sprague Dawley

This study examined the in vivo effects of Echinops spp. polysaccharide B on type 2 diabetes mellitus in Sprague-Dawley rats. We constructed a type 2 diabetes mellitus Sprague-Dawley rat models by feeding a high-fat and high-sugar diet plus intraperitoneal injection of a small dose of streptozotocin. Using this diabetic rat model, different doses of Echinops polysaccharide B were administered orally for seven weeks. Groups receiving Xiaoke pill and metformin served as positive controls. The results showed that Echinops polysaccharide B treatment normalized the weight and blood sugar levels in the type 2 diabetes mellitus rats, increased muscle and liver glycogen content, improved glucose tolerance, increased insulin secretion, and reduced glucagon and insulin resistance indices. More importantly, Echinops polysaccharide B treatment upregulated the expression of insulin receptor in the liver, skeletal muscles, and pancreas, and significantly improved the expression levels of insulin receptor substrate-2 protein in the liver and pancreas, as well as it increased insulin receptor substrate-1 expression in skeletal muscles. These two proteins play crucial roles in increasing insulin secretion and in controlling type 2 diabetes mellitus. The findings of the present study suggest that Echinops polysaccharide B could improve the status of diabetes in type 2 diabetes mellitus rats, which may be achieved by improving insulin resistance. Our study provides a new insight into the development of a natural drug for the control of type 2 diabetes mellitus.

scholarly journals Tissue‐specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models

2021 ◽  
Author(s):  
Noah Moruzzi ◽  
Francesca Lazzeri‐Barcelo ◽  
Ismael Valladolid‐Acebes ◽  
Tilo Moede ◽  
Meike Paschen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Receptor ◽  
Mouse Models ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Receptor Isoforms ◽  
Insulin Receptor Isoforms ◽  
Diabetes Mouse

scholarly journals Author Correction: NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yng‑Tay Chen ◽  
Wei‑De Lin ◽  
Wen‑Ling Liao ◽  
Ya‑Ching Tsai ◽  
Jiunn‑Wang Liao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Receptor

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yng-Tay Chen ◽  
Wei-De Lin ◽  
Wen-Ling Liao ◽  
Ya-Ching Tsai ◽  
Jiunn-Wang Liao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Insulin Receptor ◽  
Dna Methyltransferase ◽  
Genome Wide Association Study ◽  
Dna Hypermethylation ◽  
Promoter Regions ◽  
Therapy Strategy ◽  
Increased Susceptibility

Abstract Epigenetics alternation of non-genetic variation and genome-wide association study proven allelic variants may associate with insulin secretion in type 2 diabetes (T2D) development. We analyzed promoter DNA methylation array to evaluate the associated with increased susceptibility to T2D (30 cases, 10 controls) and found 1,091 gene hypermethylated in promoter regions. We performed the association study of T2D and found 698 single nucleotide polymorphisms in exon and promoter sites by using 2,270 subjects (560 cases, 1,710 controls). A comparison of DNA hypermethylation and gene silencing of mouse T2D results in our T2D patients’ results showed that the 5′-nucleotidase, cytosolic II (NT5C2) and fucosyltransferase 8 (FUT8) genes were strongly associated with increased susceptibility to T2D. DNA hypermethylation in promoter regions reduced NT5C2 gene expression, but not FUT8 in T2D patients. NT5C2 protein expression was decreased in pancreatic β-cells from T2D mice. Transient transfection NT5C2 into RIN-m5F cells down-regulated DNA methyltransferase I (DNMT1) expression and up-regulation of the insulin receptor. Moreover, NT5C2 knockdown induced in DNMT1 overexpression and insulin receptor inhibition. Taken together, these results showed that NT5C2 epigenetically regulated insulin receptor in patients and mice with T2D, and maybe provide for T2D therapy strategy.

Insulin receptor substrate polymorphisms and Type 2 diabetes mellitus

2000 ◽  
Vol 1 (3) ◽  
pp. 343-357 ◽  
Author(s):  
Giorgio Sesti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Receptor ◽  
Insulin Receptor Substrate

scholarly journals Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus

2002 ◽  
Vol 282 (2) ◽  
pp. E370-E375 ◽  
Author(s):  
Yuval Heled ◽  
Yair Shapiro ◽  
Yoav Shani ◽  
Dani S. Moran ◽  
Lea Langzam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Exercise Training ◽  
Insulin Receptor ◽  
High Energy ◽  
Serine Phosphorylation ◽  
Psammomys Obesus ◽  
Group Protein

We hypothesized that exercise training might prevent diabetes mellitus in Psammomys obesus. Animals were assigned to three groups: high-energy diet (CH), high-energy diet and exercise (EH), and low-energy diet (CL). The EH group ran on a treadmill 5 days/wk, twice a day. After 4 wk, 93% of the CH group were diabetic compared with only 20% of the EH group. There was no difference in weight gain among the groups. Both EH and CH groups were hyperinsulinemic. Epididymal fat (% of body weight) was higher in the CH group than in either the EH and or the CL group. Protein kinase C (PKC)-δ activity and serine phosphorylation were higher in the EH group. No differences were found in tyrosine phosphorylation of the insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase among the groups. We demonstrate for the first time that exercise training effectively prevents the progression of diabetes mellitus type 2 in Psammomys obesus. PKC-δ may be involved in the adaptive effects of exercise in skeletal muscles that lead to the prevention of type 2 diabetes mellitus.

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