scholarly journals Deep Learning Approach for Early Detection of Alzheimer’s Disease

2021 ◽  
Author(s):  
Hadeer A. Helaly ◽  
Mahmoud Badawy ◽  
Amira Y. Haikal
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Deep Learning ◽  
Early Detection ◽  
Learning Approach

scholarly journals Deep Learning Image Processing Technique for Early Detection of Alzheimer's Disease

2017 ◽  
Vol 107 ◽  
pp. 85-104
Author(s):  
Raju Anitha ◽  
S. Jyothi ◽  
Venkata Naresh Mandhala ◽  
Debnath Bhattacharyya ◽  
Tai-hoon Kim
Keyword(s):  
Alzheimer’S Disease ◽  
Image Processing ◽  
Alzheimer's Disease ◽  
Deep Learning ◽  
Early Detection ◽  
Processing Technique ◽  
Image Processing Technique

scholarly journals Applying a deep learning approach focusing on spatiotemporal features in early diagnosis of Alzheimer's disease

2021 ◽  
Vol 17 (S12) ◽  
Author(s):  
Eyitomilayo Yemisi Babatope ◽  
Jesus Alejandro Acosta‐Franco ◽  
Mireya Saraí García‐Vázquez ◽  
Alejandro Álvaro Ramírez‐Acosta ◽  
APIM Laboratory Citedi‐IPN
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Deep Learning ◽  
Early Diagnosis ◽  
Learning Approach ◽  
Spatiotemporal Features

scholarly journals Predicting Alzheimer’s disease progression using multi-modal deep learning approach

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Garam Lee ◽  
◽  
Kwangsik Nho ◽  
Byungkon Kang ◽  
Kyung-Ah Sohn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Deep Learning ◽  
Disease Progression ◽  
Learning Approach

scholarly journals A parameter-efficient deep learning approach to predict conversion from mild cognitive impairment to Alzheimer's disease

NeuroImage ◽  
2019 ◽  
Vol 189 ◽  
pp. 276-287 ◽  
Author(s):  
Simeon Spasov ◽  
Luca Passamonti ◽  
Andrea Duggento ◽  
Pietro Liò ◽  
Nicola Toschi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Deep Learning ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Learning Approach

scholarly journals Deep learning detection of informative features in tau PET for Alzheimer’s disease classification

2020 ◽  
Vol 21 (S21) ◽  
Author(s):  
Taeho Jo ◽  
◽  
Kwangsik Nho ◽  
Shannon L. Risacher ◽  
Andrew J. Saykin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Deep Learning ◽  
Early Detection ◽  
Medial Temporal Lobe ◽  
Memory Loss ◽  
Disease Classification ◽  
Classification Model ◽  
Tau Pet

Abstract Background Alzheimer’s disease (AD) is the most common type of dementia, typically characterized by memory loss followed by progressive cognitive decline and functional impairment. Many clinical trials of potential therapies for AD have failed, and there is currently no approved disease-modifying treatment. Biomarkers for early detection and mechanistic understanding of disease course are critical for drug development and clinical trials. Amyloid has been the focus of most biomarker research. Here, we developed a deep learning-based framework to identify informative features for AD classification using tau positron emission tomography (PET) scans. Results The 3D convolutional neural network (CNN)-based classification model of AD from cognitively normal (CN) yielded an average accuracy of 90.8% based on five-fold cross-validation. The LRP model identified the brain regions in tau PET images that contributed most to the AD classification from CN. The top identified regions included the hippocampus, parahippocampus, thalamus, and fusiform. The layer-wise relevance propagation (LRP) results were consistent with those from the voxel-wise analysis in SPM12, showing significant focal AD associated regional tau deposition in the bilateral temporal lobes including the entorhinal cortex. The AD probability scores calculated by the classifier were correlated with brain tau deposition in the medial temporal lobe in MCI participants (r = 0.43 for early MCI and r = 0.49 for late MCI). Conclusion A deep learning framework combining 3D CNN and LRP algorithms can be used with tau PET images to identify informative features for AD classification and may have application for early detection during prodromal stages of AD.

Sign in / Sign up

Export Citation Format

Share Document