Introduction. The importance of vitamin D on bone health and osteoporosis was
studied by many researchers. The main role of the Vitamin D is to absorb
calcium and phosphate and increase bone mineralization. Older people are at
an increased risk of the inadequate vitamin D production in the skin because
of lower sun exposure and reduced ability of the skin to synthesize vitamin
D. Objective. The aim of this clinical trial was to evaluate the efficacy and
tolerability of short-term (2 weeks) low energy UVB irradiation in
postmenopausal women with osteoporosis using bone mineral density and bone
turnover markers. Methods. A three-month, single-blinded, randomized,
placebo-controlled clinical trial was conducted at the University hospital in
Daegu, Republic of Korea. Fifty-two postmenopausal Korean women (older than
65 years) with osteoporosis were randomly allocated to have either low energy
UVB or placebo for 30 minutes a day for two weeks of treatment during winter.
Laboratory analysis and physical examination before and 4, 8 and 12 weeks
after treatment were carried out and BMD was measured before and 8 and 12
weeks after treatment. The effects of time and treatment interaction between
these two groups were evaluated by repeated-measure two-factor analysis, and
subgroup analysis was performed to examine UVB effect on the vitamin D
insufficient group [serum 25(OH)D3 concentration <30 ng/mL]. Results. In
vitamin D insufficient group, the effect of UVB irradiation on vitamin D and
bone ALP as well as additional benefit on bone formation was confirmed. The
vitamin D insufficient group showed statistically significant increment in
serum 25(OH)D3 compared with the normal group (p<0.05). However, there was no
significant difference between two groups in the other bone turnover markers,
such as serum calcium, PTH-C, serum osteocalcin, serum CTX and BMD.
Conclusion. Low-energy-short-term UVB radiation for postmenopausal women may
be of use in vitamin D synthesis. There was a modest benefit in change of
bone ALP especially in women with the insufficient vitamin D.
The effect of short-term low-energy ultraviolet B irradiation on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis: A randomized single-blinded controlled clinical trial
